British Dietetic Association systematic review of systematic reviews and evidence‐based practice guidelines for the use of probiotics in the management of irritable bowel syndrome in adults (2016 update)

McKenzie, Yvonne; Thompson, Julie; Gulia, P.; Lomer, Miranda

doi:10.1111/jhn.12386

Cited by 69 publications

(65 citation statements)

References 91 publications

(734 reference statements)

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“…In particular, the possibility that a starter culture is the source of mobile gene elements suggests that the genomic content, rather than just specific species, must be considered when designing microbial supplements. In addition to starter cultures used for fermented foods, living microbial supplements (‘probiotics’) are increasingly being adopted in agriculture (Verschuere et al, 2000; Chaucheyras-Durand and Durand, 2010) and for a wide range of human health conditions (Cuello-Garcia et al, 2015; Onubi et al, 2015; (IBS Dietetic Guideline Review Group on behalf of Gastroenterology Specialist Group of the British Dietetic Association) et al, 2016), and even as cosmetics (Whitlock et al, 2016). The need to screen for clinically relevant elements such as antibiotic resistance genes is widely recognized (Sanders et al, 2010), but other mobile gene elements from these organisms may also enter native microbial populations with unknown consequences.…”

Section: Discussionmentioning

confidence: 99%

Extensive horizontal gene transfer in cheese-associated bacteria

Bonham

Wolfe

Dutton

2017

eLife

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Acquisition of genes through horizontal gene transfer (HGT) allows microbes to rapidly gain new capabilities and adapt to new or changing environments. Identifying widespread HGT regions within multispecies microbiomes can pinpoint the molecular mechanisms that play key roles in microbiome assembly. We sought to identify horizontally transferred genes within a model microbiome, the cheese rind. Comparing 31 newly sequenced and 134 previously sequenced bacterial isolates from cheese rinds, we identified over 200 putative horizontally transferred genomic regions containing 4733 protein coding genes. The largest of these regions are enriched for genes involved in siderophore acquisition, and are widely distributed in cheese rinds in both Europe and the US. These results suggest that HGT is prevalent in cheese rind microbiomes, and that identification of genes that are frequently transferred in a particular environment may provide insight into the selective forces shaping microbial communities.DOI: http://dx.doi.org/10.7554/eLife.22144.001

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Section: Discussionmentioning

confidence: 99%

Extensive horizontal gene transfer in cheese-associated bacteria

Bonham

Wolfe

Dutton

2017

eLife

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“…Although the extent and quality of evidence for prebiotic supplementation in IBS to date is limited, there is some evidence for the efficacy of probiotic supplementation,27 with up to nine systematic reviews of up to 35 RCTs indicating small, but statistically significant, effects for some strains 28. Rigorous trials of individual probiotic strains are required to delineate the most effective probiotic strains for particular symptoms.…”

Section: The Role Of Diet In Ibs Managementmentioning

confidence: 99%

The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS

Staudacher

Whelan

2017

Gut

272

236

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There is an intensifying interest in the interaction between diet and the functional GI symptoms experienced in IBS. Recent studies have used MRI to demonstrate that short-chain fermentable carbohydrates increase small intestinal water volume and colonic gas production that, in those with visceral hypersensitivity, induces functional GI symptoms. Dietary restriction of short-chain fermentable carbohydrates (the low fermentable oligosaccharide, disaccharide, monosaccharide and polyol (FODMAP) diet) is now increasingly used in the clinical setting. Initial research evaluating the efficacy of the low FODMAP diet was limited by retrospective study design and lack of comparator groups, but more recently well-designed clinical trials have been published. There are currently at least 10 randomised controlled trials or randomised comparative trials showing the low FODMAP diet leads to clinical response in 50%-80% of patients with IBS, in particular with improvements in bloating, flatulence, diarrhoea and global symptoms. However, in conjunction with the beneficial clinical impact, recent studies have also demonstrated that the low FODMAP diet leads to profound changes in the microbiota and metabolome, the duration and clinical relevance of which are as yet unknown. This review aims to present recent advances in the understanding of the mechanisms by which the low FODMAP diet impacts on symptoms in IBS, recent evidence for its efficacy, current findings regarding the consequences of the diet on the microbiome and recommendations for areas for future research.

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“…The international nature of dietetic research is not captured by the BDA Symposium presented in this issue of the Journal of Human Nutrition and Dietetics, but as Editor I am proud to report that over the last year we have published work from dietitians and nutrition researchers from the UK, Australia, Canada, China, Finland, India, Iran, Ireland, Israel, Korea, Malaysia, Mexico, the Netherlands, Norway, Poland, Portugal, Spain and the United States of America. With an ever‐increasing international reach, the Journal has the capacity to inform and influence the training , practice and therapeutic guidelines followed by dietitians and clinicians all over the world.…”

mentioning

confidence: 99%

Celebrating international dietetic research

Langley‐Evans

2019

J Human Nutrition Diet

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British Dietetic Association systematic review of systematic reviews and evidence‐based practice guidelines for the use of probiotics in the management of irritable bowel syndrome in adults (2016 update)

Cited by 69 publications

References 91 publications

Extensive horizontal gene transfer in cheese-associated bacteria

Extensive horizontal gene transfer in cheese-associated bacteria

The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS

Celebrating international dietetic research

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