In 2004, the Province of British Columbia (BC) announced a multi-year $1.5 billion seismic retrofit program for the province's 750 at-risk public schools. The purpose of this program was to quantify the seismic risk of the province's public-school buildings and to expedite the seismic upgrading of the most at-risk schools. In order to provide a safe and cost-effective implementation of this program, the Engineers and Geoscientists BC, in collaboration with the University of British Columbia, has developed a performance-based probabilistic method and guidelines for the seismic risk assessment and retrofit of low-rise buildings. As part of this initiative, a number of laboratory experiments have been conducted to provide data that would support the recommendations provided in the guidelines. The laboratory experiments included several full-scale shake table tests of wood frame systems. The specimens were subjected to sequences of earthquake motions to simulate their performance under main shock-aftershocks. This paper presents details of seven of the experiment and wood-frame buildings considered. A detailed discussion of the results of the analyses of the shake table tests data, and performance assessment using drift-and energy-based damage indices is presented. This study highlights the importance of considering the effects of subduction earthquake and mainshock-aftershock sequences for design and retrofit of wood frame structures.