British Association of Dermatologists guidelines for the management of hidradenitis suppurativa (acne inversa) 2018

Ingram, John R.; Collier, Fiona; Brown, D.; Burton, T.; Burton, Jennifer K; Mf, Chin; Desai, Nemesha; Goodacre, Tim; Piguet, Vincent; Pink, Andrew E.; Ls, Exton; Mf, Mohd Mustapa

doi:10.1111/bjd.17537

Cited by 122 publications

(185 citation statements)

References 35 publications

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“…Previous case reports and clinical trials indicated benefits of TNF-a inhibitors for HS, and guidelines from several dermatology societies suggest anti-TNF monoclonal antibody adalimumab as an optional treatment for severe and refractory HS. 4,5 In contrast, only several cases treated with adalimumab have been reported for PCAS, 2,3,6-12 summarized in Table 1. In 85.7% of 14 cases, infliximab or adalimumab showed improvement of PCAS inflammatory skin symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Guidelines for HS from the European and North American societies of dermatology suggest anti-TNF monoclonal antibody adalimumab as an optional treatment for severe and refractory HS. 4,5 In contrast, reports of PCAS treated with anti-TNF antibodies are limited and the efficacy of anti-TNF antibodies for PCAS is not clear, even though PCAS is occasionally accompanied by HS. To discuss the possibility of the anti-TNF antibody treatment for PCAS, we report a case of PCAS improved by adalimumab and review the articles relating to anti-TNF antibody treatments for PCAS.…”

Section: Introductionmentioning

confidence: 99%

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Perifolliculitis capitis abscedens et suffodiens treatment with tumor necrosis factor inhibitors: A case report and review of published cases

Takahashi

Yamasaki

Terui

et al. 2019

The Journal of Dermatology

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Perifolliculitis capitis abscedens et suffodiens (PCAS) or dissecting cellulitis is a rare condition presenting deep follicular occlusions, follicular ruptures and follicular infections in the scalp area with unknown etiology, which consequently cause primary neutrophilic cicatricial alopecia by the repeated follicular inflammation. PCAS is categorized as one of the “follicular occlusion tetrad” along with hidradenitis suppurativa, acne conglobata and pilonidal cyst. In the pathogenesis of the follicular occlusion tetrad, the involvement of neutrophils and its activator tumor necrosis factor (TNF) have been discussed. Here, we report a case of PCAS that was successfully treated with adalimumab, a human anti‐TNF monoclonal antibody. This is the first Asian case of PCAS that was improved by a TNF inhibitor.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Perifolliculitis capitis abscedens et suffodiens treatment with tumor necrosis factor inhibitors: A case report and review of published cases

Takahashi

Yamasaki

Terui

et al. 2019

The Journal of Dermatology

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“…In terms of HS therapy, biologic agents, particularly targeting tumour necrosis factor alpha (TNFα), are now an integral part of the management of moderate to severe disease [79][80][81]. Although clinical benefit has been reported with several biologics, including infliximab [82], ustekinumab [83] and secukinumab [84], only adalimumab is licensed at present for the treatment of moderate to severe HS.…”

Section: The Cutaneous And/or Gastrointestinal Microbiomes As a Theramentioning

confidence: 99%

The Role of the Cutaneous Microbiome in Hidradenitis Suppurativa—Light at the End of the Microbiological Tunnel

Langan

Recke

Bokor-Billmann

et al. 2020

IJMS

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The development of next generation sequencing, coupled with advances in bio-informatics, has provided new insights into the role of the cutaneous microbiome in the pathophysiology of a range of inflammatory skin diseases. In fact, it has even been suggested that the identification of specific skin microbial signatures may not only be useful in terms of diagnosis of skin diseases but they may also ultimately help inform personalised treatment strategies. To date, research investigating the role of microbiota in the development of inflammatory skin diseases has largely focused on atopic eczema and psoriasis vulgaris. The role of the microbiome in Hidradenits suppurativa (HS)-also known as acne inversa-a chronic auto-inflammatory skin disease associated with significant morbidity, has received comparatively little attention. This is despite the fact that antimicrobial therapy plays a central role in the treatment of HS. After briefly outlining the clinical features of HS and current treatment strategies, we move on to review the evidence of microbial dysbiosis in HS pathophysiology. We conclude by outlining the potential for metagenomic studies to deepen our understanding of HS biology but more importantly to identify novel and much needed treatment strategies.scoring and the HS severity index. Whilst the precise incidence and prevalence of HS is unclear [8], due partly to the diagnostic difficulty associated with HS and the use of both registry data and self-report questionnaires [9]. Garg et al. reported a prevalence of 0.1% in a US-based population analysis, leading the authors to conclude that HS is an uncommon but not rare disease, with over-representation in young, female and African American patients [10]. The current multi-modal treatment approach includes the use of intralesional steroids, surgical and laser therapy, topical and systemic medical antimicrobial therapy and biologic treatments [11].Sartorius scoring and the HS severity index. Whilst the precise incidence and prevalence of HS is unclear [8], due partly to the diagnostic difficulty associated with HS and the use of both registry data and self-report questionnaires [9]. Garg et al. reported a prevalence of 0.1% in a US-based population analysis, leading the authors to conclude that HS is an uncommon but not rare disease, with over-representation in young, female and African American patients [10]. The current multi-modal treatment approach includes the use of intralesional steroids, surgical and laser therapy, topical and systemic medical antimicrobial therapy and biologic treatments [11].

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“…Patients have increased rates of depression and anxiety and tend to come from lower socioeconomic backgrounds . Currently, recommended treatments include tetracycline antibiotics, rifampicin and clindamycin, acitretin, dapsone and biologic agents, including adalimumab and infliximab . Surgery, weight reduction and smoking cessation are important adjuncts to treatment.…”

Section: Alternative Therapies Reported and Reasons For Use (N = 21)mentioning

confidence: 99%

Complementary and alternative medicine use in hidradenitis suppurativa

et al. 2019

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British Association of Dermatologists guidelines for the management of hidradenitis suppurativa (acne inversa) 2018

Abstract: Linked Comment: Jemec. Br J Dermatol 2019; 180:975. Plain language summary available online

Cited by 122 publications

References 35 publications

Perifolliculitis capitis abscedens et suffodiens treatment with tumor necrosis factor inhibitors: A case report and review of published cases

Perifolliculitis capitis abscedens et suffodiens treatment with tumor necrosis factor inhibitors: A case report and review of published cases

The Role of the Cutaneous Microbiome in Hidradenitis Suppurativa—Light at the End of the Microbiological Tunnel

Complementary and alternative medicine use in hidradenitis suppurativa

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