British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018

Wong, Terence H.; Morton, C.A.; Collier, N.J.; Haylett, Ann K.; Ibbotson, S.H.; McKenna, Kevin E.; Mallipeddi, R.; Moseley, Harry; Seukeran, D.C.; Rhodes, Lesley E.; Ward, Katherine; Mustapa, M.F. Mohd; Exton, L.S.; McHenry, P.; Leslie, Tabi A.; Wakelin, S. H.; Hunasehally, R.Y.P.; Cork, Michael J.; Johnston, Graham A.R.; Worsnop, Fiona; Rakvit, Pariyawan; Salim, Asad; McDonald, Bryan; Chua, Ser Ling; Buckley, David; Petrof, Gabriela; Callachand, N.; Flavell, T.; Salad, A.A.

doi:10.1111/bjd.17309

Cited by 58 publications

(63 citation statements)

References 64 publications

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“…PDT appears to have limited efficacy in PPP [90]. A guideline for topical PDT published by the British Photodermatology Group and the British Association of Dermatologists did not recommend 5-aminolevulinic acid-PDT as an effective therapy for psoriasis [91].…”

Section: Phototherapymentioning

confidence: 99%

Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments

2020

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Palmoplantar pustulosis (PPP) is a chronic, recurrent skin disease belonging to the spectrum of psoriasis. It is characterized by an eruption of sterile pustules on the palms and soles. Recent studies in PPP have focused on genetic differences between pustular phenotypes and the role of the innate immunological system and the microbiome in the etiopathogenesis of the disease. Mutations in IL36RN (a major predisposing factor for generalized pustular psoriasis) were found in selected patients with PPP and were associated with earlier disease onset. Studies have shown that the interleukin (IL)-17 and IL-36 pathways might be involved in the pathogenesis of PPP. A microbiome has been demonstrated in the vesicopustules of PPP, and an abundance of Staphylococcus appears to be increased by smoking. Improved understanding of the underlying etiopathogenesis of PPP has led to advances in treatment options, and targeted therapies for PPP have been evaluated or are under evaluation against more than 12 molecules in ongoing clinical trials.

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Section: Phototherapymentioning

confidence: 99%

Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments

2020

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“…This updated guideline seeks to promote safe and effective practice across Europe in the delivery of topical photodynamic therapy (PDT) in dermatological indications and reflects evidence derived from a systematic literature review and previous PDT and disease-specific therapy guidelines. [1][2][3][4][5][6] Recommendations concerning emerging indications for topical PDT are reviewed in Part II. 7 Photodynamic therapy involves the activation of a photosensitizing drug by visible light to produce reactive oxygen species within target cells, resulting in their destruction with additional immune-modulatory effects observed.…”

Section: Introductionmentioning

confidence: 99%

European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

Morton¹,

Szeimies

Basset-Séguin

et al. 2019

Acad Dermatol Venereol

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138

146

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Topical photodynamic therapy (PDT) is a widely approved therapy for actinic keratoses, Bowen's disease (squamous cell carcinoma in situ), superficial and certain thin basal cell carcinomas. Recurrence rates when standard treatment protocols are used are typically equivalent to existing therapies, although inferior to surgery for nodular basal cell carcinoma. PDT can be used both as lesional and field therapies and has the potential to delay/reduce the development of new lesions. A protocol using daylight to treat actinic keratoses is widely practised, with conventional PDT using a red light after typically a 3‐h period of occlusion employed for other superficial skin cancer indications as well as for actinic keratoses when daylight therapy is not feasible. PDT is a well‐tolerated therapy although discomfort associated with conventional protocol may require pain‐reduction measures. PDT using daylight is associated with no or minimal pain and preferred by patient. There is an emerging literature on enhancing conventional PDT protocols or combined PDT with another treatment to increase response rates. This guideline, published over two parts, considers all current approved and emerging indications for the use of topical PDT in dermatology, prepared by the PDT subgroup of the European Dermatology Forum guidelines committee. It presents consensual expert recommendations reflecting current published evidence.

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“…Other expected skin phototoxicity effects, notably erythema and oedema, resolve rapidly over a few days and longer‐term adverse effects, such as pigmentary change, scarring or contact allergy, are uncommon. Thus, PDT has an important place in the management options of patients with superficial nonmelanoma skin cancer and dysplasia as highlighted in current guidelines …”

Section: Discussionmentioning

confidence: 99%

“…The theoretical risk of carcinogenesis with cumulative PDT treatments is unproven; indeed, PDT can be considered as a prophylactic approach in high‐risk patients, such as the immunosuppressed. This review summarizes the current evidence relating to the adverse effects of topical PDT as part of the guideline updating project on this subject, and interprets this evidence in the context of patient risk (Table ).…”

Section: The Adverse Effects Of Topical Photodynamic Therapymentioning

confidence: 99%

Adverse effects of topical photodynamic therapy: a consensus review and approach to management

et al. 2018

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British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018

Cited by 58 publications

References 64 publications

Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments

Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments

European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

Adverse effects of topical photodynamic therapy: a consensus review and approach to management

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