Bringing host-cell takeover by pathogenic bacteria to center stage

Dubreuil, Ron; Segev, Nava

doi:10.4161/cl.1.4.18984

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Notably, mathematical modeling of the evolution of the insect endosymbiont Buchnera aphidicola showed that metabolic requirements could determine not only the end point of genomic reduction but to some extent also the order of the gene deletion 38 . Moreover, the reductive trend is countered by proliferation of genes involved in parasite-host interaction such as, for example, ankyrin repeat proteins that act as secreted virulence factors 39 – 40 . Quantitatively, however, in most parasites and symbionts, these processes make a relatively minor contribution compared to the massive genome reduction.…”

Section: Box 1 Reconstruction Of Ancestral Genomes: Maximum Parsimonymentioning

confidence: 99%

Genome reduction as the dominant mode of evolution

2013

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A common belief is that evolution generally proceeds towards greater complexity at both the organismal and the genomic level, numerous examples of reductive evolution of parasites and symbionts notwithstanding. However, recent evolutionary reconstructions challenge this notion. Two notable examples are the reconstruction of the complex archaeal ancestor and the intron-rich ancestor of eukaryotes. In both cases, evolution in most of the lineages was apparently dominated by extensive loss of genes and introns, respectively. These and many other cases of reductive evolution are consistent with a general model composed of two distinct evolutionary phases: the short, explosive, innovation phase that leads to an abrupt increase in genome complexity, followed by a much longer reductive phase, which encompasses either a neutral ratchet of genetic material loss or adaptive genome streamlining. Quantitatively, the evolution of genomes appears to be dominated by reduction and simplification, punctuated by episodes of complexification.

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Section: Box 1 Reconstruction Of Ancestral Genomes: Maximum Parsimonymentioning

confidence: 99%

Genome reduction as the dominant mode of evolution

2013

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“…Bacteria use the proteins containing typically eukaryotic domains encoded by horizontally acquired DNA sequences as injected “effector” molecules to modulate host cell metabolism and defenses in order to facilitate the infection process [ 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 ]. The ability of many infectious bacteria to grow in diverse eukaryotic hosts, such as amoebae and mammals [ 230 ], apparently plays an important role in the acquisition of eukaryotic domains from one kind of host (e.g., amoebae) and their utilization as invasion functions in another kind of host (e.g., mammals).…”

Section: Adaptations Acquired and Comingled By Horizontal Transfermentioning

confidence: 99%

Nothing in Evolution Makes Sense Except in the Light of Genomics: Read–Write Genome Evolution as an Active Biological Process

Shapiro

2016

Biology

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The 21st century genomics-based analysis of evolutionary variation reveals a number of novel features impossible to predict when Dobzhansky and other evolutionary biologists formulated the neo-Darwinian Modern Synthesis in the middle of the last century. These include three distinct realms of cell evolution; symbiogenetic fusions forming eukaryotic cells with multiple genome compartments; horizontal organelle, virus and DNA transfers; functional organization of proteins as systems of interacting domains subject to rapid evolution by exon shuffling and exonization; distributed genome networks integrated by mobile repetitive regulatory signals; and regulation of multicellular development by non-coding lncRNAs containing repetitive sequence components. Rather than single gene traits, all phenotypes involve coordinated activity by multiple interacting cell molecules. Genomes contain abundant and functional repetitive components in addition to the unique coding sequences envisaged in the early days of molecular biology. Combinatorial coding, plus the biochemical abilities cells possess to rearrange DNA molecules, constitute a powerful toolbox for adaptive genome rewriting. That is, cells possess “Read–Write Genomes” they alter by numerous biochemical processes capable of rapidly restructuring cellular DNA molecules. Rather than viewing genome evolution as a series of accidental modifications, we can now study it as a complex biological process of active self-modification.

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Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model

et al. 2018

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The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.

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Bringing host-cell takeover by pathogenic bacteria to center stage

Cited by 4 publications

References 21 publications

Genome reduction as the dominant mode of evolution

Genome reduction as the dominant mode of evolution

Nothing in Evolution Makes Sense Except in the Light of Genomics: Read–Write Genome Evolution as an Active Biological Process

Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model

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