Bringing home the bacon? The next step in cardiac sodium channelopathies

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

“…Some have argued that the absence of a BrS phenotype is due to the young age of the minipigs (22 months). 219 However, it is difficult to reconcile why the minipigs manifest major conduction delays at this age but not a BrS phenotype, if indeed the latter depends on the former. Finally, it is noteworthy that monophasic APs recorded from the epicardial and endocardial surfaces of the RVOT of a patient with BrS are nearly identical to transmembrane APs recorded from the epicardial and endocardial surfaces of the wedge model of BrS.…”

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

“…Some have argued that the absence of a BrS phenotype is due to the young age of the minipigs (22 months). 219 It is however difficult to reconcile why the minipigs manifest major conduction delays at this age but not a BrS phenotype, if indeed the latter depends on the former. Finally, it is noteworthy that monophasic APs recorded from the epicardial and endocardial surfaces of the RVOT of a patient with BrS are nearly identical to transmembrane APs recorded from the epicardial and endocardial surfaces of the wedge model of BrS.…”

J‐Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

“…These observations are expected because of the lack of I to in the pig, which is a prerequisite for the development of the repolarization abnormalities associated with BrS. Some have argued that the absence of a BrS phenotype is due to the young age of the minipigs (22 months) [219] . However, it is difficult to reconcile why the minipigs manifest major conduction delays at this age but not a BrS phenotype, if indeed the latter depends on the former.…”