Brine Shrimp Toxicity Evaluation Of Some Tanzanian Plants Used Traditionally For The Treatment Of Fungal Infections

Moshi, Mainen J.; Beukel, Carolien J. P. van den Bout-van den; Hamza, Omar J M; Mbwambo, Zakaria H.; Nondo, Ramadhani O S; Masimba, Pax J.; Matee, Mecky; Kapingu, Modest C.; Mikx, F. H. M.; Verweij, Paul E.; Ven, A.J.A.M. van der

doi:10.4314/ajtcam.v4i2.31211

Cited by 40 publications

(38 citation statements)

References 8 publications

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“…Some plant extracts including Mentha arvensis, Eugenia caryophyllus, and Decaspermum momtanum exhibited 100%, mortality whereas extracts of Cymbopogon citratus exhibited about 30%, mortality at the same concentration (Sukari, 1992). The results of Moshi et al (2007) indicate that 9, out of 44, plant species exhibited high toxicity with LC 50 values below 20µg/ml, also, 11, plants gave low toxicity (LC 50 values of 50-100µg/ml), and 18, plants gave LC 50 values greater than 100µg/ml.…”

Section: Table1mentioning

confidence: 90%

The antibacterial activity of traditionally used Salvadora Persica L. (miswak) and Commiphora Gileadensis (palsam) in Saudi Arabia

Al‐Sieni¹

2013

Afr. J. Trad. Compl. Alt. Med.

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Background: Nowadays there is a need to find naturally occurring substances from plants with antimicrobial activity as an alternative to available used antibiotics. Materials and Methods: Salvadora persica (miswak) and Commiphora gileadensis were collected, dried and extracted with either methanol or warm water and the obtained extracts were assessed for their antibacterial activity against 5 different genera of bacteria using agar well diffusion method. The tested bacteria included some human pathogens. Results: The obtained extracts exhibited considerable inhibitory effects against all the tested bacteria with various degrees of growth inhibition. It was shown that methanol extract was more effective compared to water extracts. The minimum inhibitory concentrations (MIC) of the methanol extracts ranged from 50-100 µg/ml. No toxicity was found using Artimia salina as test organism and no antitumor activity against Ehrlich ascites carcinoma. Conclusion: S. persica and C. gileadensis showed moderate to high inhibitory activity on pathogenic bacteria with no toxicity and can be used traditionally as alternative medicine .

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Section: Table1mentioning

confidence: 90%

The antibacterial activity of traditionally used Salvadora Persica L. (miswak) and Commiphora Gileadensis (palsam) in Saudi Arabia

Al‐Sieni¹

2013

Afr. J. Trad. Compl. Alt. Med.

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“…The results obtained from animal studies will be crucial in giving a definitive judgment concerning the safety of the plants if they are discovered to have sufficient nutritional and therapeutic potentials for development into pharmacological products (Marco et al, 2013;Moshi, 2007).…”

Section: Discussionmentioning

confidence: 99%

Effects of ethanol and aqueous leaf extracts of Pterocarpus mildbraedii on hematology parameters and cholesterol in albino rats

Victor¹,

Nonyelum²

2017

Afr. J. Biochem. Res.

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One of the commonly consumed leafy vegetables in Nigeria is, on two groups of rats for 28 days showed no adverse effects on the hematological parameters considered in this study. There was a significant (p < 0.05) dose dependent increase in almost all the hematological parameters. However, the serum cholesterol level was significantly reduced in rats exposed to both doses of the ethanol and aqueous extracts of the plant leaf as compared to the rats in the control group. These effects of the extracts increased with increased doses. These results suggest non-toxic effects of the leaf extracts of P. mildbraedii on the hematological parameters, as well as an ability to help in preventing cardiovascular diseases in the diabetics.

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“…In the brine shrimp bioassay, the 70% methanol extract of the root exhibited a 100% mortality rate at a concentration of 1000 µg/ml (Adiele et al, 2013), while the 80% methanol root extract exhibited an LC 50 of 77.1 µg/ml (Moshi et al, 2007), suggesting that these extracts are relatively toxic. However, the brine shrimp assays have some problems as the counting of the viable larvae is performed while the live larvae are continually moving around the petri dish.…”

Section: Toxicologymentioning

confidence: 99%

“…A root decoction may also be drunk to treat fever, malaria, hernias, gonorrhoea, palpitations, headaches, oedema, rheumatism, diabetes, sexual impotence, toothache, fungal infections and malaria (Maroyi, 2013;Ogunmefun and Gbile, 2012;Chhabra et al, 1991;Moshi et al, 2007). …”

Section: Rootsmentioning

confidence: 99%

Securidaca longipedunculata Fresen (Polygalaceae): A review of its ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology

Mongalo

McGaw

Finnie

et al. 2015

Journal of Ethnopharmacology

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Ethnopharmacologicalrelevance: Securidaca longipedunculata Fresen (Polygalaceae) is a multi-purpose plant with a long history of use in African traditional medicine to treat various sexually transmitted infections, hernias, coughs, fever, ascariasis, constipation, headaches, rheumatism, stomach ache, malaria, tuberculosis, pain, epilepsy, pneumonia, skin infections, and it is also used as an aphrodisiac for men. The current paper provides an overview of the present phytochemistry, toxicology, ethnomedicinal uses and pharmacological properties of S. longipedunculata. Materials and methods:The information reported in this paper was collected from a literature search using various computerised databases including ScienceDirect, Moreover, the pharmacokinetic properties of extracts and compounds of the species need to be explored as there is insufficient data available on these aspects.

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Brine Shrimp Toxicity Evaluation Of Some Tanzanian Plants Used Traditionally For The Treatment Of Fungal Infections

Abstract: Plants which are used by traditional healers in Tanzania have been evaluated to obtain preliminary data of their toxicity using the brine shrimps test. The results indicate that 9 out of 44 plant species whose extracts were tested exhibited high toxicity with LC 50 values below 20µg/ml.

Cited by 40 publications

References 8 publications

The antibacterial activity of traditionally used <i>Salvadora Persica</i> L. (miswak) and <i>Commiphora Gileadensis</i> (palsam) in Saudi Arabia

The antibacterial activity of traditionally used <i>Salvadora Persica</i> L. (miswak) and <i>Commiphora Gileadensis</i> (palsam) in Saudi Arabia

Effects of ethanol and aqueous leaf extracts of Pterocarpus mildbraedii on hematology parameters and cholesterol in albino rats

Securidaca longipedunculata Fresen (Polygalaceae): A review of its ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology

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