Brimonidine–timolol versus brinzolamide–timolol for treatment of elevated intraocular pressure after phacoemulsification surgery

Balsak, Selahattin; Kaydu, Ayhan; Erdem, Seyfettin; Alakuş, Mehmet Fuat; Özkurt, Zeynep

doi:10.1007/s10792-017-0626-z

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…; Balsak et al. ). These also presented a marked effect at 3–8 hr (20.5–36.5%) and day 1 (18.8–33.5%).…”

Section: Resultsmentioning

confidence: 97%

“…; Balsak et al. ). As a relatively new medication, brinzolamide + brimonidine was studied in only one trial, graded as high quality of evidence.…”

Section: Resultsmentioning

confidence: 97%

“…One of the study arms (Balsak et al. ) had major IOP peaks in 12 patients, which represented 26% of the patients in the control group at 3–8 hr. In contrast, nine treatment arms reported of no patients with major IOP peaks in the control group at 3–8 hr, while 18 treatment arms found no patients with major IOP peaks in the intervention group.…”

Section: Resultsmentioning

confidence: 99%

“…A postoperative elevated IOP is very common, resulting in IOP spikes >30 mmHg within the first 24 hr in up to 26% of eyes operated with the technique mentioned above (Balsak et al. ). However, the severity of an elevated IOP, after uncomplicated cataract surgery in an otherwise healthy eye, is still up for debate (Tranos et al.…”

Section: Introductionmentioning

confidence: 99%

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Prophylactic treatment of intraocular pressure elevation after uncomplicated cataract surgery in nonglaucomatous eyes – a systematic review

Holm

Bach‐Holm

Holm

et al. 2019

Acta Ophthalmologica

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The purpose of this systematic review was to evaluate the literature regarding prophylactic treatment of intraocular pressure (IOP) elevation after uncomplicated cataract surgery to provide an evidence-based guideline for cataract surgeons. The relevant literature was identified in EMBASE and PubMed. The risk of bias was assessed according to the 'Cochrane Handbook for Systematic Reviews of Interventions' and the ROBINS-I tool. The Grading of Recommendation, Assessment, Development and Evaluation (GRADE) criteria were used to rate the quality of evidence, and relevant data were systematically extracted to evaluate the pressure-lowering effect of the active substances. The primary outcomes for this systematic review were the absolute and relative pressure-lowering effect of the different drugs after 3-8 hr and 1 day after surgery. In total, 23 randomized controlled trials and one nonrandomized controlled study consisting of 45 treatment arms with 14 different active substances were included in the qualitative synthesis. According to the GRADE criteria, nine trials were graded as 'high' quality of evidence, 12 trials as 'moderate', while three trials were given the grade 'low' quality of evidence. The primary outcomes showed most consistency between the trials, which studied the effect of timolol, and presented a relative effect from 18.6% to 29.6% at 3-8 hr and 9.8% to 23.6% at day 1. This systematic review indicates that timolol, latanoprost and travoprost alone or medications containing timolol as an additive active substance, such as dorzolamide + timolol, brinzolamide + timolol and brimonidine + timolol, are characterized by a good relative IOP-lowering effect, which can be gained by a single dose postoperatively.

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“…; Balsak et al. ). These also presented a marked effect at 3–8 hr (20.5–36.5%) and day 1 (18.8–33.5%).…”

Section: Resultsmentioning

confidence: 97%

“…; Balsak et al. ). As a relatively new medication, brinzolamide + brimonidine was studied in only one trial, graded as high quality of evidence.…”

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prophylactic treatment of intraocular pressure elevation after uncomplicated cataract surgery in nonglaucomatous eyes – a systematic review

Holm

Bach‐Holm

Holm

et al. 2019

Acta Ophthalmologica

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show abstract

“…Prevention of IOP spikes is achieved with topical IOP lowering medication or more frequently with administration of oral acetazolamide [ 24 ]. This can be done preoperatively or postoperatively.…”

Section: Cataract Operation and Intraocular Pressurementioning

confidence: 99%

Surgical and Perioperative Considerations for the Treatment of Cataract in Eyes with Glaucoma: A Literature Review

Tsakiris

Kontadakis

Georgoudis

et al. 2021

Journal of Ophthalmology

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Cataract surgery in the presence of glaucoma poses certain challenges that need to be addressed to offer the maximum benefit without complications. In this paper, we are reviewing the preoperative assessment, surgical options, the planning, and postoperative care. Cataract surgery can help reduce the intraocular pressure alone or combined with MIGS. When performed in patients with glaucoma, it can transiently increase the intraocular pressure and later on decrease the IOP to levels lower than the postoperative. The preoperative IOP and biometric characteristics are the main predictors of the postoperative course of IOP. The combination of cataract surgery with trabeculectomy remains controversial, in terms of best timing of each operation.

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Treatment of Postoperative Intraocular Pressure Increase

Hirneiß¹

2023

Cataract and Lens Surgery

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Brimonidine–timolol versus brinzolamide–timolol for treatment of elevated intraocular pressure after phacoemulsification surgery

Abstract: We demonstrate that the postoperative administration of FCBT or FCBZT is effective in lowering IOP after phacoemulsification cataract surgery; FCBZT more effectively lowered IOP than FCBT at postoperative days 3 and 5.

Cited by 8 publications

References 21 publications

Prophylactic treatment of intraocular pressure elevation after uncomplicated cataract surgery in nonglaucomatous eyes – a systematic review

Prophylactic treatment of intraocular pressure elevation after uncomplicated cataract surgery in nonglaucomatous eyes – a systematic review

Surgical and Perioperative Considerations for the Treatment of Cataract in Eyes with Glaucoma: A Literature Review

Treatment of Postoperative Intraocular Pressure Increase

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