Brimonidine-induced punctual eversion: An uncommon adverse effect

Abstract

Brimonidine is a highly selective alpha-2 adrenoreceptor agonist which is primarily used to treat glaucoma and ocular hypertension. It has a well-known profile for adverse reactions, the common local ones being periocular dermatitis, allergic conjunctivitis, hyperaemia, and dry eyes. Here, we present two unusual cases of punctal eversion following the administration of brimonidine eye drops. On cessation of the medication, we could haul the progression of the condition. These cases highlight the importance of vigilance on the safety profile of drugs, manifestation of adverse drug reactions, and prompt withdrawal of the offending agent.