Brillouin scattering study on crystalline and glassy states of anti-inflammatory racemic S(+)–R(−) ibuprofen

Ko, Jae‐Hyeon; Kim, Tae Hyun; Lee, Kwang-Sei; Kojima, Seiji

doi:10.1016/j.cplett.2011.09.024

Cited by 10 publications

(8 citation statements)

References 23 publications

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“…The FWHM in the liquid phase is much larger than the values in the glassy state. This behavior is similar to the cases of ibuprofen and ketoprofen, which exhibits the maximum of the FWHM in the liquid phase [ 20 , 26 ].…”

Section: Resultssupporting

confidence: 70%

“…Figure 5 shows the comparison of the Brillouin shift and the FWHM of four pharmaceuticals, progesterone, aspirin [ 17 ], ibuprofen [ 20 ], and acetaminophen [ 23 ]. All these pharmaceuticals were investigated upon heating after melting and quenching to 77 K for vitrification.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, these acoustic waves can couple to fast relaxation dynamics, the characteristic frequency of which is in the GHz~THz range. Previous Brillouin scattering studies on aspirin [ 17 , 18 , 19 ], ibuprofen [ 20 , 21 , 22 ], acetaminophen [ 23 ], and other pharmaceuticals [ 24 , 25 , 26 ] revealed clear anomalies near the glass transition temperatures ( T g ) and fast relaxation processes that coupled to the longitudinal acoustic waves. The present study is aimed at investigating and comparing acoustic properties of progesterone in its glassy, ultraviscous, crystalline, and liquid states.…”

Section: Introductionmentioning

confidence: 99%

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Acoustic Anomalies and Fast Relaxation Dynamics of Amorphous Progesterone as Revealed by Brillouin Light Scattering

Kim

Yoo

2017

Materials

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The amorphous state of pharmaceuticals has attracted much attention due to its high bioavailability and other advantages. The stability of the amorphous state in relation with the local molecular mobility is important from both fundamental and practical points of view. The acoustic properties of amorphous progesterone, one of the representative steroid hormones, were investigated by using a Brillouin inelastic light scattering technique. The Brillouin spectrum of the longitudinal acoustic mode exhibited distinct changes at the glass transition and the cold-crystallization temperatures. The acoustic dispersions of the longitudinal sound velocity and the acoustic absorption coefficient were attributed to the fast and possibly the secondary relaxation processes in the glassy and supercooled liquid states, while the structural relaxation process was considered as the dominant origin for the significant acoustic damping observed even in the liquid phase. The persisting acoustic dispersion in the liquid state was attributed to the single-molecule nature of the progesterone which does not exhibit hydrogen bonds in the condensed states.

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Section: Resultssupporting

confidence: 70%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acoustic Anomalies and Fast Relaxation Dynamics of Amorphous Progesterone as Revealed by Brillouin Light Scattering

Kim

Yoo

2017

Materials

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“…The frequency shift and the linewidth provide the sound velocity and the acoustic attenuation of acoustic waves thermally excited in a material, respectively. Recently, acoustic properties of pharmaceutical aspirin and ibuprofen in their crystalline, glassy and liquid states were investigated by Brillouin scattering, from which acoustic anomaly across a glass transition was clearly observed [16][17][18]. In addition, Brilloun scattering is sensitive to the existence of intramolecular secondary relaxation which couples with acoustic phonon in a GHz range [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Acoustic and thermal anomalies in a liquid–glass transition of racemic S(+)–R(−) ketoprofen

Shibata

Takayama

Kim

et al. 2014

Chemical Physics Letters

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Acoustic and thermal properties of pharmaceutical racemic S(+)-R(-) ketoprofen were investigated in wide temperature range including glassy, supercooled liquid and liquid states by Brillouin scattering and temperature modulated DSC (MDSC). Sound velocity and acoustic attenuation exhibit clear changes at 265 K indicating a liquid-glass transition and show the typical structural relaxation above Tg. The high value of the fragility index m = 71 has been determined by the dispersion of the complex heat capacity. New relaxation map was suggested in combination with previous study of dielectric measurement.

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“…On the other hand, commercial product on the market is the racemic RS mixture. The crystal structure and the glass transition of racemic ibuprofen have been studied by various experimental methods, for example, dielectric [5e7], structural [8e10], Raman [11], and acoustic [12] studies. Regarding the comparison between the racemic and the enantiomorphic S-ibuprofen, there are only few reports up to now [13e15].…”

Section: Introductionmentioning

confidence: 99%

Relaxation behaviors of enantiomorphic S-ibuprofen as revealed by dielectric and photon correlation spectroscopies

Shin

Hwang

et al. 2015

Current Applied Physics

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Brillouin scattering study on crystalline and glassy states of anti-inflammatory racemic S(+)–R(−) ibuprofen

Cited by 10 publications

References 23 publications

Acoustic Anomalies and Fast Relaxation Dynamics of Amorphous Progesterone as Revealed by Brillouin Light Scattering

Acoustic Anomalies and Fast Relaxation Dynamics of Amorphous Progesterone as Revealed by Brillouin Light Scattering

Acoustic and thermal anomalies in a liquid–glass transition of racemic S(+)–R(−) ketoprofen

Relaxation behaviors of enantiomorphic S-ibuprofen as revealed by dielectric and photon correlation spectroscopies

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