Brilacidin, a novel antifungal agent against
Cryptococcus neoformans
Camila Diehl,
Camila Figueiredo Pinzan,
Patrícia Alves de Castro
et al.
Abstract:Cryptococcus neoformans
causes cryptococcosis, one of the most prevalent fungal diseases, generally characterized by meningitis. There is a limited and not very effective number of drugs available to combat this disease. In this manuscript, we show the host defense peptide mimetic brilacidin (BRI) as a promising antifungal drug against
C. neoformans
. BRI can affect the organization of the cell membrane, increasing the fungal cell permeability. We also investigated the… Show more
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