“…Indeed, previously we have shown that GABAergic mechanisms affect melatonin release (Kalsbeek et al, 1996(Kalsbeek et al, , 1999(Kalsbeek et al, , 2000. Several papers have delineated melatonin secretion in narcolepsy patients, primarily focusing on whether altered melatonin secretion could contribute to EDS and nocturnal sleep disturbances (Ahmed et al, 1991;Birau et al, 1982aBirau et al, , 1982bBlazejova et al, 2000Blazejova et al, , 2008Hajek et al, 1989). Although most of these studies found melatonin levels within the normal range in narcolepsy patients, in a more recent study Blazejova et al (2008) discovered elevated saliva melatonin levels during the day in almost half of the patients.…”