Bright Light Delights: Effects of Daily Light Exposure on Emotions, Restactivity Cycles, Sleep and Melatonin Secretion in Severely Demented Patients

Münch, Mirjam; Schmieder, Michael; Bieler, K.; Goldbach, Rolf; Fuhrmann, Timo; Zumstein, Naomi; Vonmoos, Petra; Scartezzini, Jean-Louis; Wirz‐Justice, Anna; Cajochen, Christian

doi:10.2174/1567205014666170523092858

Cited by 29 publications

(95 citation statements)

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“…More generally, sunny rooms improve outcomes after a first attack of myocardial infarction (Beauchemin & Hays, ); improve sleep in medical wards (Bano et al., ); and reduce the need of painkillers after spinal surgery (Walch et al., ). Architects are now constructing psychiatric wards or retirement homes using the new technology and chronotherapeutic principles (Kallestad, Morken, & Langsrud, ; Münch et al., ). Conversely, there is growing awareness of the potential influence of LED lighting on mental illness (Bauer et al., ).…”

Section: Where Are We Today?mentioning

confidence: 99%

Perspectives in affective disorders: Clocks and sleep

Wirz‐Justice

Benedetti

2019

Eur J of Neuroscience

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Mood disorders are often characterised by alterations in circadian rhythms, sleep disturbances and seasonal exacerbation. Conversely, chronobiological treatments utilise zeitgebers for circadian rhythms such as light to improve mood and stabilise sleep, and manipulations of sleep timing and duration as rapid antidepressant modalities. Although sleep deprivation (“wake therapy”) can act within hours, and its mood‐elevating effects be maintained by regular morning light administration/medication/earlier sleep, it has not entered the regular guidelines for treating affective disorders as a first‐line treatment. The hindrances to using chronotherapeutics may lie in their lack of patentability, few sponsors to carry out large multi‐centre trials, non‐reimbursement by medical insurance and their perceived difficulty or exotic “alternative” nature. Future use can be promoted by new technology (single‐sample phase measurements, phone apps, movement and sleep trackers) that provides ambulatory documentation over long periods and feedback to therapist and patient. Light combinations with cognitive behavioural therapy and sleep hygiene practice may speed up and also maintain response. The urgent need for new antidepressants should hopefully lead to reconsideration and implementation of these non‐pharmacological methods, as well as further clinical trials. We review the putative neurochemical mechanisms underlying the antidepressant effect of sleep deprivation and light therapy, and current knowledge linking clocks and sleep with affective disorders: neurotransmitter switching, stress and cortico‐limbic reactivity, clock genes, cortical neuroplasticity, connectomics and neuroinflammation. Despite the complexity of multi‐system mechanisms, more insight will lead to fine tuning and better application of circadian and sleep‐related treatments of depression.

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Section: Where Are We Today?mentioning

confidence: 99%

Perspectives in affective disorders: Clocks and sleep

Wirz‐Justice

Benedetti

2019

Eur J of Neuroscience

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“…Several studies have found that lighting intervention in AD significantly increased circadian entrainment and sleep efficiency [49,50], together with reducing symptoms of depression [51].…”

Section: Discussionmentioning

confidence: 99%

Epigenetic Regulation of BMAL1 with Sleep Disturbances and Alzheimer’s Disease

Hulme

Didikoglu

Bradburn

et al. 2020

JAD

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Background: An early symptom of Alzheimer’s disease (AD) is a disturbance of the circadian rhythm that is associated with disrupted sleep/wake cycles. Objective: To investigate if BMAL1, a key gene that drives the circadian cycle, is epigenetically regulated in brains in relation to longitudinal changes in cognition, sleep quality, and AD neuropathology. Methods: Frontal cortex tissues were acquired from the Manchester Brain Bank (N = 96). DNA methylation at six CpG sites at the promoter of BMAL1, determined using bisulfite pyrosequencing, was tested for associations with Braak stage, CERAD score and Thal phase, longitudinal changes in cognition, sleep measurements and cross-section measures of depressive symptoms (BDI score). Results: Methylation across all the CpGs strongly correlated with each other. We found increased CpG2 methylation with higher Braak (t(92), p = 0.015) and CERAD (t(94), p = 0.044) stages. No significance was found between longitudinal fluid intelligence, processing speed and memory tests, but methylation at CpG1 (r = 0.20, p = 0.05) and CpG4 (r = 0.20, p = 0.05) positively correlated with vocabulary. CpG2 positively correlated with cross-sectional fluid intelligence (r = 0.20 p = 0.05) and vocabulary (r = 0.22 p = 0.03). Though longitudinal analysis revealed no significance between sleep duration, midsleep and efficiency for any of the CpG sites, CpG3 (B = 0.03, 95% CI, p = 0.03) and CpG5 (B = 0.04, 95% CI, p = 0.01) significantly correlated with night wake. CpG4 correlated with depressive symptoms (B = –0.27, 95% CI, p = 0.02). Conclusion: Methylation of BMAL1 associated with tau pathology, changes in cognitive measures, a measure of sleep and depressive symptoms, suggesting an involvement of the circadian cycle.

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“…Higher exposure to daylight was because: 1) the Grand Café environment had windows; 2) residents in the Beach Room wore sunglasses as opposed to the residents in the Grand Café environment that didn't, which could have prevented optimal absorption of light from the lamp. Research has demonstrated that exposure to daylight is able to positively affect the behavioral and psychological disturbances as well as the sleep-wake cycles in people with dementia [16][17][18]. Therefore, considering these two possible explanations, physical activity and exposure to daylight might be having a greater role in providing effectiveness in reducing behavioral and psychological disturbances in the nursing-home residents with dementia, in comparison to enriched thematic multi-sensory stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…The room contained common items of old-fashioned furniture and attributes (e.g., lamps and a clock) as well as the Suntech Trippel Lamp (identical to the lamp placed in the Beach Room). It was decided to include the Suntech Trippel Lamp in both the conditions because, as reported by previous studies, the light from this lamp is itself expected to exert a positive impact on psychological and behavioral disturbances [16][17][18]. If the conversations did not evolve naturally among the residents in the Grand Café, a nurse/occupational therapist maintained the continuity of the conversation, which could be regarding any topic.…”

Section: Experimental and Control Conditionsmentioning

confidence: 99%

Effects of Enriched Thematic Multi-Sensory Stimulation on BPSD in A Beach Room: A Pilot Study among Nursing-Home Residents with Dementia

Verkaik¹,

Eerden²,

Spreeuwenberg³

et al. 2019

obm geriatr

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Background: Studies conducted on the effectiveness of psychosocial interventions have indicated that sensory stimulation represents a promising approach to reduce the psychological and behavioral disturbances in people with dementia. Multi-sensory stimulation involves the simultaneous stimulation of multiple senses, through the use of various methods, for example, by using a variety of lights, gentle stimulating music, aromas,

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Bright Light Delights: Effects of Daily Light Exposure on Emotions, Restactivity Cycles, Sleep and Melatonin Secretion in Severely Demented Patients

Cited by 29 publications

References 0 publications

Perspectives in affective disorders: Clocks and sleep

Perspectives in affective disorders: Clocks and sleep

Epigenetic Regulation of BMAL1 with Sleep Disturbances and Alzheimer’s Disease

Effects of Enriched Thematic Multi-Sensory Stimulation on BPSD in A Beach Room: A Pilot Study among Nursing-Home Residents with Dementia

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