Resistance and insufficient attention to the applicable standards are typical explanations of pesticide treatment failure to insecticide resistance such as organophosphates and control agents. There is therefore a need for a safer, cheaper and more efficient investigation of mosquito control agents with new modes of actions. Recently, biologically produced nanoparticles have been seen as a possible strategy to fighting malaria vectors and also as a therapy for mosquito illnesses. Here we provide current understanding on the efficacy of biogenic nanoparticles (NPs) in vector-borne conditions.