Brief review: Glucocorticoid excretion in obesity

Müssig, Karsten; Maser-Gluth, Christiane

doi:10.1016/j.jsbmb.2010.01.008

Cited by 33 publications

(23 citation statements)

References 64 publications

(87 reference statements)

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“…Gender analyses showed that self-reported depression was particularly associated with inadequate glycemic control in women (AOR 19.8). Abdominal obesity (25) and smoking (22) are well-known risk factors for poor glycemic control and have been associated with dysfunction of the cortisol metabolism (38,39), which is also the case for depression (1). This shared underlying mechanism should be further explored.…”

Section: Discussionmentioning

confidence: 99%

Depression, obesity, and smoking were independently associated with inadequate glycemic control in patients with type 1 diabetes

Melin

Thunander

Svensson³

et al. 2013

European Journal of Endocrinology

129

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Objective: The aim of this study was to explore the associations between inadequate glycemic control of diabetes and psychological, anthropometric, and lifestyle variables in a population-based cohort of type 1 diabetes patients. Design: Cross-sectional study. Methods: In this study, 292 patients with type 1 diabetes, aged 18-59 years, participated. Psychological data were assessed by self-report instruments: Hospital Anxiety and Depression Scale and Toronto Alexithymia Scale-20. Anthropometrics, blood analyses, data from medical records, and data from the Swedish National Diabetes Registry were collected. Results: Self-reported depression (adjusted odds ratio (AOR) 4.8), obesity (AOR 4.3), and smoking (AOR 3.0) were independently associated with inadequate glycemic control of diabetes (HbA1cO8.6%). Gender-stratified analyses showed that self-reported depression (AOR 19.8) and obesity (AOR 7.0) in women and smoking in men (AOR 4.2) were associated with HbA1cO8.6%. Alexithymia, antidepressant medication, and physical inactivity were associated with HbA1cO8.6% only in bivariate analyses. Alexithymia, self-rated anxiety, physical inactivity, and absence of abdominal obesity were associated with self-reported depression. Conclusions: Depression was the only psychological factor independently associated with HbA1cO 8.6%. The association was of comparable importance as obesity and smoking, well-known risk factors for inadequate glycemic control and diabetes complications. The association between depression and HbA1cO8.6% was particularly strong for women. Alexithymia, which is a relatively stable personality trait, was associated with depression. In the future care of patients with diabetes, psychological aspects should be considered alongside anthropometrics and lifestyle factors in order to achieve the goals for HbA1c.

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Section: Discussionmentioning

confidence: 99%

Depression, obesity, and smoking were independently associated with inadequate glycemic control in patients with type 1 diabetes

Melin

Thunander

Svensson³

et al. 2013

European Journal of Endocrinology

129

View full text Add to dashboard Cite

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“…Normal cortisol levels are found even in patients with abdominal obesity [34]. Thus, systemic levels of cortisol in plasma cannot be considered as a marker or factor that induces abdominal obesity in otherwise healthy adults [39]. …”

Section: Cortisol Metabolism In Watmentioning

confidence: 99%

“…In mice, 11β-HSD1 predominantly catalyzes conversion of 11-dehydro-corticosterone into active corticosterone. Cortisol can be inactivated to cortisone by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in the WAT [39]. The link between 11β-HSD1/11β-HSD2 and obesity was established in Dr. Jeff Flier's laboratory [7, 40, 41].…”

Section: Cortisol Metabolism In Watmentioning

confidence: 99%

“…The preferential abdominal fat depot formation by 11β-HSD1 was also explained by fat-depot-specific cortisol excretion from WAT [52]. Abdominal adiposity in patients correlates with urinary cortisol excretion rates (reviewed in [39]). In healthy men, cortisol is released from subcutaneous fat depots, whereas no secreted cortisol from abdominal fat depots was detected [52].…”

Section: Cortisol Metabolism In Watmentioning

confidence: 99%

“…The changes in 11β-HSD2 levels in these animals have both systemic and local effects on metabolism, via decreased production of cytokines (leptin and resistin) and up-regulation of thermogenic Ucp2 . However, it has been hypothesized that overexpression of 11β-HSD2 in other tissues, such as kidney, increases systemic cortisone levels for utilization by the adipose tissue [39]. In spite of encouraging data in animal models, the targeting of 11β-HSD1/11β-HSD2 pathways for treatment of visceral obesity may cause significant side effects in other tissues because adipose tissue substantially contributes to the systemic pool of cortisone/cortisol.…”

Section: Cortisol Metabolism In Watmentioning

confidence: 99%

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DiSilvestro

Petrosino

Aldoori

et al. 2014

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Abdominal fat formation has become a permanent risk factor for metabolic syndrome and various cancers in one-third of the world's population of obese and even lean patients. Formation of abdominal fat involves additional mechanisms beyond an imbalance in energy intake and expenditure, which explains systemic obesity. In this review, we briefly summarized autonomous regulatory circuits that locally produce hormones from inactive precursors or nutrients for intra-/auto-/paracrine signaling in white adipose depots. Enzymatic pathways activating steroid and thyroid hormones in adipose depots were compared with enzymatic production of retinoic acid from vitamin A. We discussed the role of intracrine circuits in fat-depot functions and strategies to reduce abdominal adiposity through thermogenic adipocytes with interrupted generation of retinoic acid.

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Sheesley

2016

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The Chronic Care Model developed for the multidisciplinary management of chronic diseases provides a blueprint for the integrated role of mental health counselors supporting clients with obesity seeking weight management treatment. Counselors can support clients and the team of health care professionals treating obesity within each of the 6 components of the model: (a) health care organization, (b) delivery‐system design, (c) clinical information systems, (d) decision support, (e) client self‐management support, and (f) community resources.

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Brief review: Glucocorticoid excretion in obesity

Cited by 33 publications

References 64 publications

Depression, obesity, and smoking were independently associated with inadequate glycemic control in patients with type 1 diabetes

Depression, obesity, and smoking were independently associated with inadequate glycemic control in patients with type 1 diabetes

Enzymatic intracrine regulation of white adipose tissue

Counselors Within the Chronic Care Model: Supporting Weight Management

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