Brief report. Serum magnesium levels in protein-energy malnutrition

Singla, P. N.; Chand, Prakash; Kumar, Ashok; Kachhawaha, J. S.

doi:10.1093/tropej/44.2.117

Cited by 15 publications

(17 citation statements)

References 6 publications

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“…However, this prevalence is much lower than the 20.7% [19] and 51.9% [49] deficiency reported in Mexican and Vietnamese children. In addition, consistent with previous study in India [50], serum magnesium levels had significant positive correlations with height-for-age. Lower serum magnesium levels in malnourished children may be due to inadequate intake, malabsorption, diarrhoea, and infection.…”

Section: Discussionsupporting

confidence: 92%

Micronutrient levels and nutritional status of school children living in Northwest Ethiopia

Amare

Moges

Fantahun

et al. 2012

Nutr J

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BackgroundSeveral micronutrients are essential for adequate growth of children. However, little information is available on multiple micronutrient status of school children in Ethiopia. The present study was designed to evaluate the relationship between multiple micronutrient levels and nutritional status among school children.MethodIn this cross-sectional study, anthropometric data, blood and stool samples were collected from 100 children at Meseret Elementary School in Gondar town, Northwest Ethiopia. Serum concentration of magnesium, calcium, iron, copper, zinc, selenium and molybdenum were measured by inductively coupled plasma mass spectrometer. Anthropometric indices of weight-for-age, height-for-age and BMI-for-age were used to estimate the children's nutritional status. Stool samples were examined by standard microscopic methods for intestinal parasites.ResultsThe prevalence of stunting, underweight, wasting and intestinal parasitoses among school children was 23%, 21%, 11% and18%, respectively. The mean serum levels of magnesium, calcium, iron, copper, zinc, selenium and molybdenum were 2.42±0.32 (mg/dl), 15.31±2.14 (mg/dl), 328.19±148.91 (μg/dl), 191.30±50.17 (μg/dl), 86.40±42.40 (μg/dl), 6.32±2.59 (μg/dl), and 0.23±0.15 (μg/dl), respectively. Selenium deficiency, zinc deficiency and magnesium deficiency occurred in 62%, 47%, and 2% of the school children, respectively. Height-for-age showed significant positive correlation with the levels of copper and molybdenum (p = 0.01) and with the levels of magnesium (p = 0.05).ConclusionDeficiencies of selenium and zinc were high among the school children although the deficiencies were not significantly related with their nutritional status. The prevalence of both malnutrition and intestinal parasitism was not negligible. These calls for the need to undertake multicentre studies in various parts of the country to substantiate the data obtained in the present study so that appropriate and beneficial strategies for micronutrient supplementation and interventions on nutritional deficiencies can be planned.

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Section: Discussionsupporting

confidence: 92%

Micronutrient levels and nutritional status of school children living in Northwest Ethiopia

Amare

Moges

Fantahun

et al. 2012

Nutr J

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“…In Tanzania, the combination of ascariasis and iron deficiency was found to be linked to low weight gain among children, while schistosomiasis was correlated with low height gains. 29 Similar links have been found between malnutrition and low serum magnesium levels, 30 imbalances be-tween n-6 and n-3 fatty acids, 31 vitamin E-related neurologic deficits, 32 and low levels of bioavailable zinc. 33 While the causal nature of such relationships is often uncertain, it is clear that macronutrient status, illness, and micronutrient deficiencies are interrelated and that the nature and severity of food insecurity influence the precise outcome.…”

Section: Iron Deficiency and Iron Deficiency Anemiamentioning

confidence: 58%

Age and Gender as Factors in the Distribution of Global Micronutrient Deficiencies

2008

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Although micronutrient deficiency is a global problem, the burden is not evenly shared within affected households. This review suggests that there are important non-linearities in relationships among food intake, sharing, and caring behavior within the household. Since micronutrient status relates to interactions among biological, social, behavioral, economic, and environmental processes, outcomes are not always predictable by age, gender, or location. Understanding such variability is crucial to identifying appropriate solutions. This review represents an exploratory first step toward unmasking population-specific variations that are important for better understanding the nature of micronutrient deficiencies and for improving the focus of public health action.

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“…Several hypotheses have been proposed. First, a possible reason for the link between lower magnesium and in-hospital mortality is that lower magnesium at admission might reflect high BP [22,23], high blood glucose [24,25], severe state of malnutrition [26], and severe renal disease [27], which are known predictors of poor outcome and mortality of stroke in previous studies [28,29,30,31,32,33]. Second, previous animal studies indicated that magnesium could improve the blood flow in the ischemic area of the brain and enhance recovery of cellular energy metabolism after ischemia [34,35].…”

Section: Discussionmentioning

confidence: 99%

Admission Low Magnesium Level Is Associated with In-Hospital Mortality in Acute Ischemic Stroke Patients

You

Zhong²,

Du³

et al. 2017

Cerebrovasc Dis

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Background: Low magnesium levels are associated with an elevated risk of stroke. In this study, we investigated the association between magnesium levels on hospital admission and in-hospital mortality in acute ischemic stroke (AIS) patients. Methods: A total of 2,485 AIS patients, enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city, were included in this study. The patients were divided into 4 groups according to their level of admission magnesium: Q1 (<0.82 mmol/L), Q2 (0.82-0.89 mmol/L), Q3 (0.89-0.98 mmol/L), and Q4 (≥0.98 mmol/L). Cox proportional hazard model was used to estimate the effect of magnesium on all-cause in-hospital mortality in AIS patients. Results: During hospitalization, 92 patients (3.7%) died from all causes. The lowest serum magnesium level (Q1) was associated with a 2.66-fold increase in the risk of in-hospital mortality in comparison to Q4 (hazard ratio [HR] 2.66; 95% CI 1.55-4.56; p-trend < 0.001). After adjusting for age, sex, time from onset to hospital admission, baseline National Institutes of Health Stroke Scale score, and other potential covariates, HR for Q1 was 2.03 (95% CI 1.11-3.70; p-trend = 0.014). Sensitivity and subgroup analyses further confirmed a significant association between lower magnesium levels and a high risk of in-hospital mortality. Conclusions: Decreased serum magnesium levels at admission were independently associated with in-hospital mortality in AIS patients.

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Brief report. Serum magnesium levels in protein-energy malnutrition

Cited by 15 publications

References 6 publications

Micronutrient levels and nutritional status of school children living in Northwest Ethiopia

Micronutrient levels and nutritional status of school children living in Northwest Ethiopia

Age and Gender as Factors in the Distribution of Global Micronutrient Deficiencies

Admission Low Magnesium Level Is Associated with In-Hospital Mortality in Acute Ischemic Stroke Patients

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