Brief Report: Mapping Colorectal Distribution of Cell-Free and Cell-Associated HIV Surrogates Following Simulated Anal Intercourse to Aid Rectal Microbicide Development
Ethel D. Weld,
Ken Ogasawara,
Edward J. Fuchs
et al.
Abstract:Background.
Anal sex remains the greatest HIV transmission risk for men who have sex with men and carries substantial population attributable risk among women. Despite a growing array of HIV pre-exposure prophylaxis (PrEP) options, rectal microbicides remain desirable as on demand, non-systemic PrEP. Rectal microbicide product development for PrEP requires understanding the spatiotemporal distribution of HIV infectious elements in the rectosigmoid to optimize formulation development.
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