Brief Report: European Mitochondrial Haplogroups Impact on Liver Fibrosis Progression Among HCV and HIV/HCV-Coinfected Patients From Northwest Spain

Abstract

The impact of mitochondrial DNA haplogroups on the outcome of liver fibrosis was evaluated in 362 hepatitis C virus infection (HCV)-monoinfected and HIV/HCV-coinfected patients (147 and 215, respectively) in clinical follow-up at 2 reference hospitals in the Northwest of Spain. The mitochondrial DNA haplogroup H was the most prevalent (50.3%) in this population. The cluster Others and V were recognized as risk factors for the development of liver fibrosis while haplogroup H and HCV genotype 4 confer a lower risk. This information might be useful for prioritization of HCV treatment, especially for F0-F1 patients for whom there is no urgency for treatment.

European mitochondrial haplogroups predict liver-related outcomes in patients coinfected with HIV and HCV: a retrospective study

“…Preliminary studies have also shown associations between mtDNA haplogroups and clinical outcomes in patients with HIV infection [12, 13], including clinical progression [14–17], CD4+ T cell recovery after combination antiretroviral therapy (cART) [18], metabolic disorders [19, 20], and toxicities due to nucleoside reverse-transcriptase inhibitors (e.g., peripheral neuropathy and lipoatrophy) [21, 22]. In previous reports, an association between major European mtDNA haplogroups and liver fibrosis in HIV/HCV-coinfected patients were also found [23, 24], but the design of this studies was cross-sectional.…”