Brief Report: Effect of Intravenous Methotrexate Dose and Infusion Rate on Neuropsychological Function One Year after Diagnosis of Acute Lymphoblastic Leukemia

Carey, Marissa; Hockenberry, Marilyn J.; Moore, Ida M.; Hutter, John J.; Krull, Kevin R.; Pasvogel, Alice; Kaemingk, Kristine L.

doi:10.1093/jpepsy/jsj114

Cited by 48 publications

(38 citation statements)

References 8 publications

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“…7,44 In the current study, verbal (Digit Span) and visual (Trail Making 4) attention measures were significantly weaker for survivors of ALL compared with the healthy controls, and these measures correlated (r Ͼ 0.420) with regional frontal white matter volumes, though the correlations did not reach statistical significance by using a P value of Ͻ. 01 in this small sample.…”

Section: Discussioncontrasting

confidence: 65%

Reduced Frontal White Matter Volume in Long-Term Childhood Leukemia Survivors: A Voxel-Based Morphometry Study

Carey¹,

Haut²,

Reminger³

et al. 2008

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:To our knowledge, no published studies have examined whole-brain regional differences to identify more discrete volumetric changes in the brains of childhood leukemia survivors. We used voxel-based morphometry (VBM) to examine regional gray and white matter differences in a group of long-term survivors of acute lymphoblastic leukemia (ALL) compared with a group of healthy controls. Differences in regional white matter volume were expected, given previous reports of white matter changes during treatment for ALL and reduced brain white matter volumes in long-term survivors. Follow-up analyses examined the relationship of regional brain volumes to cognitive function.

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Section: Discussioncontrasting

confidence: 65%

Reduced Frontal White Matter Volume in Long-Term Childhood Leukemia Survivors: A Voxel-Based Morphometry Study

Carey¹,

Haut²,

Reminger³

et al. 2008

AJNR Am J Neuroradiol

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“…In contrast, other studies show cognitive difficulties in children treated with chemotherapy and also demonstrate worse performance in children treated with higher doses [Carey et al, 2007]. Although rehabilitation interventions have not been well studied in this population, some research suggests the potential to improve cognitive difficulties with intervention .…”

Section: Brain Tumors and Acute Lymphoblastic Leukemiamentioning

confidence: 87%

Predictors of outcome following acquired brain injury in children

Johnson¹,

DeMatt²,

Salorio³

2009

Dev Disabil Res Revs

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Acquired brain injury (ABI) in children and adolescents can result from multiple causes, including trauma, central nervous system infections, noninfectious disorders (epilepsy, hypoxia/ischemia, genetic/metabolic disorders), tumors, and vascular abnormalities. Prediction of outcomes is important, to target interventions, allocate resources, provide education to family or caregivers, and begin appropriate planning for the future. Researchers have identified several factors associated with better or worse outcomes after ABI, including variables related to the injury itself, postinjury factors related to intervention or trajectory of recovery, and preinjury or demographic factors. When examining the scientific literature, it is important to identify how "outcome" is defined, as the predictors may change depending on the outcome studied. In addition, key variables may be specific to the etiology of injury. Therefore, predictors of outcome cannot be generalized across the various etiologies of ABI, and this review will discuss predictors within the context of multiple etiologies of ABI. This article reviews the current literature on predicting outcomes after pediatric ABI, and areas in need of further research are discussed.

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“…Although one expects large groups of children to have mean IQ scores that approximate the population mean of 100, ALL patients tend to obtain IQ scores above 100 when assessed within weeks of diagnosis. Baseline IQs range from 99 to 115 with Performance IQ slightly higher than verbal IQ in most cases [Soni et al, 1975;Stehbens and Kisker, 1984;Copeland et al, 1988;Brown et al, 1996;Jansen et al, 2005Jansen et al, , 2006Nathan et al, 2006;Carey et al, 2007]. Furthermore, siblings of ALL patients exhibit mean full scale IQs near 110 [Moss et al, 1981;Jannoun, 1983;Twaddle et al, 1983;Taylor et al, 1987;Giralt et al, 1992;Jansen et al, 2005].…”

Section: Methodological Issuesmentioning

confidence: 99%

“…On-treatment studies IQ scores of children on active CO treatment are at least average [Williams et al, 1986;MacLean et al, 1995;Krappman et al, 2007;Moore et al, 2008], with no evidence of decline over the course of treatment [Copeland et al, 1988;Dowell et al, 1989;Brown et al, 1996;Copeland et al, 1996;Carey et al, 2007]. However, difficulties with perceptual motor speed [Copeland et al, 1988[Copeland et al, , 1996, working memory [Carey et al, 2007], academic achievement [Brown et al, 1996], and fine motor skills [Dowell et al, 1989;Hockenberry et al, 2007] have been reported.…”

Section: Chemotherapy-onlymentioning

confidence: 99%

Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment

Janzen

Spiegler

2008

Dev Disabil Res Revs

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This review will describe the neurocognitive outcomes associated with pediatric acute lymphoblastic leukemia (ALL) and its treatment. The literature is reviewed with the aim of addressing methodological issues, treatment factors, risks and moderators, special populations, relationship to neuroimaging findings, and directions for future research. It is concluded that neurocognitive outcomes for the majority of children with standard-risk ALL treated according to current chemotherapy protocols is relatively good, but subgroups of children are more significantly compromised. As medical treatments advance and survival rates continue to improve, neurocognitive outcomes and other quality of life indicators will become increasingly important. Preventing or ameliorating treatment-related neuropsychological sequelae represents the next major challenge in pediatric ALL.

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Brief Report: Effect of Intravenous Methotrexate Dose and Infusion Rate on Neuropsychological Function One Year after Diagnosis of Acute Lymphoblastic Leukemia

Abstract: Findings suggest that difficulties in working memory and nonverbal skills may be evident during the first year of treatment for ALL and that severity may be dependent on IV MTX dose and/or infusion rate.

Cited by 48 publications

References 8 publications

Reduced Frontal White Matter Volume in Long-Term Childhood Leukemia Survivors: A Voxel-Based Morphometry Study

Reduced Frontal White Matter Volume in Long-Term Childhood Leukemia Survivors: A Voxel-Based Morphometry Study

Predictors of outcome following acquired brain injury in children

Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment

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