Brief Report: Does Menopause Transition Influence Viral Suppression and Adherence in Women Living With HIV?

Hachfeld, Anna; Atkinson, Andrew; Stute, Petra; Calmy, Alexandra; Tarr, Philip; Darling, Katharine E A; Flury, Bernhard; Polli, Christian; Sultan‐Beyer, Leila; Abela, Irene A.; Aebi‐Popp, Karoline

doi:10.1097/qai.0000000000003158

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…However, we did identify a correlation between depression and HC in CW<40, in line with previous reports (57)(58)(59). Although previous results showed that mental health was not associated with adherence to ART or viral suppression during menopausal transition (60), more studies are needed in CW and TW with HIV to investigate the interplay between sex hormone intake, mental health, and immunity.…”

Section: Discussionsupporting

confidence: 90%

Delineating the effect of sex hormone intake on immunity in cis and trans women with HIV

Pasin

Nuñez

Kusejko

et al. 2023

Preprint

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BackgroundAlthough sex hormones are recognized to induce immune variations, little is known on the effect of exogenous sex hormone intake on immune responses in cis and trans women. Here, we aimed at quantifying how sex hormone intake affects HIV-1 immune markers in cis women (CW) and trans women (TW) with HIV.MethodsWe considered measurements of key HIV-1 immune markers (CD4, CD8, lymphocyte counts, and CD4:CD8 ratio) from cis men (CM), CW, and TW enrolled in the Swiss HIV Cohort Study. We modeled immune markers using linear mixed-effects models with an interaction between the variables “group” (CW, TW) and “with sex hormone intake” (yes/no). We conducted serum proteomics measurements of 92 inflammation markers on samples from 31 TW before and after sex hormone intake to assess the inflammation environment.ResultsWe included 54’141 measurements from 3’092 CW and 83 TW sampled between 2015 and 2022, and 147’298 from 8’611 CM. Sex hormone intake was associated with significant distinct effects on CD4 and CD4:CD8 ratio between the different groups of women (p=0.0025 and 0.015). TW with sex hormone intake had significantly higher CD4 counts (median = 772 (1Q-3Q=520-1’006)) than without (median = 617 (1Q-3Q=426-892)). This increase was similar in magnitude to the difference in CD4 counts between CW and CM. None of the serum inflammation proteins showed significant concentration difference before and after sex hormone intake in TW.ConclusionThis study highlights the need to consider the potential role of sex hormone intake in modulating the immune system among other biological and social factors, especially in TW in HIV.

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Section: Discussionsupporting

confidence: 90%

Delineating the effect of sex hormone intake on immunity in cis and trans women with HIV

Pasin

Nuñez

Kusejko

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

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“…Данные относительно влияния ВИЧ-инфекции на возраст наступления менопаузы расходятся: сообщается о более раннем ее начале у женщин, живущих с ВИЧ,-среднем на 3 года, причем у 29,7% имела место ранняя менопауза [16]. В исследовании, проведенном в 2022 г. в Швейцарии, ранняя менопауза встречалась у каждой десятой ВИЧ-инфицированной женщины [17]. В то же время есть данные об отсутствии различий в возрасте наступления менопаузы у пациенток с ВИЧ по сравнению с популяционными показателями [18].…”

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Features of menopausal period in HIV-positive women

Samarina,

Yarmolinskaya,

Koloshkina

2024

VIČ-infekc. immunosupr.

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In 2021 in Russia, the proportion of women among HIV-infected patients was 54.6%. In recent years, there has been an increase in the number of female patients of older reproductive age and those in peri- and postmenopause among women living with HIV. Data on the age of onset of menopause and its course in this group of women are contradictory, and clinical recommendations on the features of dispensary observation, the choice of antiretroviral therapy, and the treatment of climacteric syndrome in this group of patients are absent, despite its high frequency and greater intensity of manifestations compared to population indicators. The insufficient amount of research on this topic, low awareness of doctors about the possibilities of prescribing menopausal hormone therapy to HIV-positive patients, and drug interactions between MHT and antiretroviral drugs limit the provision of effective medical care, worsen the quality of life of HIV-positive women, and represent a problem that requires a solution. This article offers a review of modern studies aimed at studying the peculiarities of menopause in women with HIV, the age of its onset, and data on the prescription of MHT. Literature search was conducted on PubMed, and the review includes articles published from 2016 to 2023.

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Management of menopause in women living with HIV – A comparative guideline review

Scofield,

Moseholm,

Aebi-Popp

et al. 2024

Maturitas

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Brief Report: Does Menopause Transition Influence Viral Suppression and Adherence in Women Living With HIV?

Cited by 5 publications

References 30 publications

Delineating the effect of sex hormone intake on immunity in cis and trans women with HIV

Delineating the effect of sex hormone intake on immunity in cis and trans women with HIV

Features of menopausal period in HIV-positive women

Management of menopause in women living with HIV – A comparative guideline review

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