Brief Communications: Carcinogenic and Hepatotoxic Effects of Diethylnitrosamine in Hedgehogs

Graw, Johannes J.; Berg, Hugo; Schmähl, D.

doi:10.1093/jnci/53.2.589

Cited by 6 publications

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“…Young adult Sprague-Dawley (Charles River Breeding Laboratories, Inc.) 6 week old rats of both sexes were individually caged in a room with constant temperature at 25 C, and fed a Purina Chow diet. Administration of DENA started after one week of acclimation.…”

Section: Methodsmentioning

confidence: 99%

Ultrastructure of altered hepatocytes induced by diethylnitrosamine (DENA)

Zaki

1982

Toxicol Pathol

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Administration of diethylnitrosamine I.P. at dose level of 2 mg/kg five days a week to young Sprague-Dawley rats induced foci of altered hepatocytes entirely devoid of glucose-6-phosphatase and adenosine triphosphatase activity. Several weeks later, these foci developed hepatocellular carcinoma mostly of the trabecular type. Although these "preneoplastic" altered cells appeared as normal hepatocytes when examined in HE-sections, they were found to exhibit sites of dedifferentiation with ultrastructural features of hepatoma cells. Early morphological changes indicative of neoplastic transformation took place first as excessive storage of glycogen then as marked alterations at the surface membranes of such cells. Striking increase in coated pinocytotic vesicles appeared along the apposing cell membranes associated with loss of sinusoidal microvilli, protrusion of cytoplasmic blebs in the intercellular spaces, reduction or loss of desmosomes and obliteration of bile canaliculi. Subsequent changes were seen as dilation and disruption of the rough endoplasmic reticulum (RER), dispersal of ribosomes, proliferation and clustering of the smooth endoplasmic reticulum (SER), predominance of annulate lamellae, depletion of glycogen, enlargement of the Golgi cisterns and segregation of nucleolar elements. After 20 weeks, rats given DENA at a dose level of 25 mg/kg twice a week developed pronounced cirrhotic nodules in addition to multiple hepatocellular carcinoma. In contrast to the neoplastic nodules, the cirrhotic ones retained normal activity of glucose-6-phosphatase and adenosine triphosphatase and exhibited ultrastructural features typical of normal hepatocytes.

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Section: Methodsmentioning

confidence: 99%

Ultrastructure of altered hepatocytes induced by diethylnitrosamine (DENA)

Zaki

1982

Toxicol Pathol

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“…[49] 50% Tu.-Dosis = 122 mg/ Meerschweinchen Auch am Hund [50,51], am Huhn [52], der Katze [52], dem Igel [53], dem Schwein [54,55], dem Kaninchen [56,57], dem Wellensittich [58], der Mongolischen Rennmaus [59,60], an verschiedenen Fischspezies [61,62] und an der Schlange [63] ebenso wie an verschiedenen Affenspezies [64,65,66] zeigte N-Nitrosodiethylamin eine stark-kanzerogene Wirkung, wobei die Leber als Zielorgan -insgesamt gesehen -ganz im Vordergrund steht; allerdings zeigt sich häufig auch der Respirationstrakt -einschließlich der Nasenhöhle -als besonders empfindlich. Trotz der großen Verschiedenartigkeit der Spezies liegen die zur Tumorerzeugung durch N-Nitrosodiethylamin notwendigen Dosen nicht sehr weit auseinander.…”

Section: N-nitrosodiethylaminunclassified

N‐Nitrosamine [MAK Value Documentation in German language, 1987]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 13. Lieferung, Ausgabe 1987 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter N‐Nitrosamine am Arbeitsplatz Das Problem des Zusammenwirkens verschiedener N‐Nitrosamine Zurkanzerogenen Wirkung N‐Nitrosodimethylamin N‐Nitrosomethylethylamin N‐Nitrosodiethylamin N‐Nitrosodi‐n‐propylamin N‐Nitrosodi‐i‐propylamin N‐Nitrosodi‐n‐butylamin N‐Nitrosodiethanolamin N‐Nitrosomethylphenylamin N‐Nitrosoethylphenylamin N‐Nitrosomorpholin N‐Nitrosopiperidin N‐Nitrosopyrrolidin Zur Frage von MAK‐Werten

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N‐Nitrosamines [MAK Value Documentation, 1990]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 1 (1990) The article contains sections titled: Toxic Effects and Modes of Action N‐Nitrosamines in the occupational environment Combined Action of N‐Nitrosamines Carcinogenicity Manifesto (MAK value, classification)

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Brief Communications: Carcinogenic and Hepatotoxic Effects of Diethylnitrosamine in Hedgehogs

Cited by 6 publications

References 0 publications

Ultrastructure of altered hepatocytes induced by diethylnitrosamine (DENA)

Ultrastructure of altered hepatocytes induced by diethylnitrosamine (DENA)

N‐Nitrosamine [MAK Value Documentation in German language, 1987]

N‐Nitrosamines [MAK Value Documentation, 1990]

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