Brief Communication: Intramitochondrial Bodies in a Human Cell Line Carrying Oncornavirus-Like Particles2

Keydar, J.; Braslawsky, Gary R.; Dajbog, Tamar; Karby, Shulamit; Shinedling, Sidney T.; Weiss, Fannie; Delarea, Jacob

doi:10.1093/jnci/54.1.247

Cited by 7 publications

(1 citation statement)

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“…Specifically, viral or subviral particles are reported to be present in mitochondria of virusinduced Rous sarcomas [1-3], chick leukemia erythroblasts [4], reticulocndotheliosis virus-infected chick liver cells [5], Rous sarcoma virus-infected ham ster cells [6][7][8], and mouse embryo fibroblasts treated with supernatant from a mouse mammary tumor cell line, and a human amnion cell line treated with supernatant derived from several human mammary tumors [9], In view of these findings, we have directed our research efforts toward the Address inquiries to: Dr.…”

Section: Abstract Intramitochondrial Virus Morphogenesis • Ultrastrmentioning

confidence: 99%

An Ultrastructural Study and Model of Membrane-Intramitochondrial Virus Relationships

Lunger

Clark²

1976

Intervirology

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Intramitochondrial virions (IMV), in many respects structurally similar to ‘C-type¹ viruses of higher organisms, are synthesized in close topographical association with inner mitochondrial membranes of the viper spleen cell line, VSW. Cristal membranes contribute to the formation of a trilaminar viral envelope, whereas the outer mitochondrial membrane does not appear to play any structural role in virion maturation. Two schematic models, correlated with electron microscopic images, are presented to depict: (a) the relative location of the particles within a three-dimensional view of the mitochondrion, and (b) the sequence of virion-mitochondrial membrane relationships during morphogenesis.

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Section: Abstract Intramitochondrial Virus Morphogenesis • Ultrastrmentioning

confidence: 99%

An Ultrastructural Study and Model of Membrane-Intramitochondrial Virus Relationships

Lunger

Clark²

1976

Intervirology

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Manifestation of carcinogenesis as a stochastic process on the basis of an altered mitochondrial genome

1981

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Computer calculations are used to show the feasibility of a concept which explains the manifestation of a pathological cell function from a latent state by the phenomenon of extrachromosomal inheritance (through the mitochondrial genome) in mammalian cells. A hypothesis is submitted in which this principle is applied to the process of carcinogenesis. According to this concept, the manifestation of a tumor cell--after the initiation stage--entirely depends on stochastic events, i.e., random distribution of mitochondria during cell divisions, with an accumulation of the lesion in a few out of many cells. We feel that this concept comprises a better explanation of many characteristics and peculiarities of the phenomenon of carcinogenesis than do attempts which explain tumor formation as a phenomenon caused by mutation in a nuclear genome. A consideration of the principles presented automatically leads to a number of specific consequences with regard to carcinogenesis. Some of these consequences are discussed. They include: 1. the process of malignant transformation should not be irreversible for all the cells of a progeny; 2. the number of mitochondria in a cell type should be inversely correlated to tumor frequency; 3. the latent period should mainly be determined by the cell division rate and the "extent" of the initiating event; 4. susceptibility to carcinogenesis may be substantially higher if the number of mitochondria per cell line is increasing or decreasing, i.e., during the embryonic and fetal periods; 5. heterogeneous types of cells may arise from a single "initiated" cell, and 6. the process of malignant transformation should not necessarily be confined to one generation of the species. In addition, experimental approaches to support the submitted concept are suggested.

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Biosynthesis of subviral oncogenic particles (virosomes) in mitochondria of rous sarcoma and Rauscher murine leukemia cells

1977

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Experimental evidence for the presence and biosynthesis of subviral, leukemogenic particles in the isolated mitochondria of spleen cells of mice infected with Rauscher murine leukemia (RML) virus is presented. These subviral particles sediment at a density of 1.27-1.29 g/ml and induce splenomegaly and RML three weeks after i.v. or i.p. administration to white mice. Virosomes have been labelled with [32P]phosphate in the isolated mitochondria from RML spleen cells and high molecular weight (70S) [32P]RNA has been isolated from these subviral, leukemogenic particles. Rauscher virus group specific antigens were detected by immunodiffusion in the inner membrane and matrix fraction of the mitochondria of RML spleen cells. These results together with our earlier findings strongly suggest that mitochondria of the transformed cells participate in the biosynthesis of RNA tumor viruses. Possible mechanism of the penetration of viral genetic information of RNA tumor viruses into mitochondria of tumor cells in vivo is discussed.

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Brief Communication: Intramitochondrial Bodies in a Human Cell Line Carrying Oncornavirus-Like Particles2

Cited by 7 publications

References 0 publications

An Ultrastructural Study and Model of Membrane-Intramitochondrial Virus Relationships

An Ultrastructural Study and Model of Membrane-Intramitochondrial Virus Relationships

Manifestation of carcinogenesis as a stochastic process on the basis of an altered mitochondrial genome

Biosynthesis of subviral oncogenic particles (virosomes) in mitochondria of rous sarcoma and Rauscher murine leukemia cells

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