Brief circadian rhythm disruption does not impair hippocampal dependent memory when rats are over-trained and given more re-entrainment days

Newman, Abigail W.; Deibel, Scott H.; Lewis, Leanna M.; Viguers, Kayla; Thorpe, Christina M.

doi:10.1016/j.lmot.2020.101613

Cited by 2 publications

(2 citation statements)

References 52 publications

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“…Here, we asked whether CK1δ/ε inhibition might also be used to improve cognitive performance in the absence of disease, potentially by shifting the phase of the internal circadian clock to a time of greater cognitive capacity. The oscillation of both clock genes and learning and memory-related genes in the hippocampus suggests that these rhythms might be targetable 1 , 44 .…”

Section: Discussionmentioning

confidence: 99%

Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice

Mahoney

Peterson

Justin

et al. 2021

Sci Rep

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Time-of-day effects have been noted in a wide variety of cognitive behavioral tests, and perturbation of the circadian system, either at the level of the master clock in the SCN or downstream, impairs hippocampus-dependent learning and memory. A number of kinases, including the serine-threonine casein kinase 1 (CK1) isoforms CK1δ/ε, regulate the timing of the circadian period through post-translational modification of clock proteins. Modulation of these circadian kinases presents a novel treatment direction for cognitive deficits through circadian modulation. Here, we tested the potential for PF-670462, a small molecule inhibitor of CK1δ/ε, to improve cognitive performance in C57BL/6J mice in an array of behavioral tests. Compared to vehicle-treated mice tested at the same time of the circadian day, mice treated with PF-670462 displayed better recall of contextual fear conditioning, made fewer working memory errors in the radial arm water maze, and trained more efficiently in the Morris Water Maze. These benefits were accompanied by increased expression of activity-regulated cytoskeleton-associated protein (Arc) in the amygdala in response to an acute learning paradigm. Our results suggest the potential utility of CK1δ/ε inhibition in improving time-of-day cognitive performance.

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Section: Discussionmentioning

confidence: 99%

Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice

Mahoney

Peterson

Justin

et al. 2021

Sci Rep

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“…In rats, our lab studies the effect of light-dark cycles of a day length outside of the range of entrainment on learning and memory ( Devan et al, 2001 ; Craig and McDonald, 2008 ; McDonald et al, 2013 ; Zelinski et al, 2013 , 2014b ; Deibel et al, 2014 , 2019 ; Newman et al, 2019 ; Lewis et al, 2020 ). A light dark cycle in which the periodicity is anything other than 24 h is called a T cycle ( Stephan, 1983 ; Campuzano, 1998 ).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Sleep, K-Complexes, and Sleep Spindles in a T21 Light-Dark Cycle

et al. 2020

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Circadian rhythm misalignment has a deleterious impact on the brain and the body. In rats, exposure to a 21-hour day length impairs hippocampal dependent memory. Sleep, and particularly K-complexes and sleep spindles in the cortex, have been hypothesized to be involved in memory consolidation. Altered K-complexes, sleep spindles, or interaction between the cortex and hippocampus could be a mechanism for the memory consolidation failure but has yet to be assessed in any circadian misalignment paradigm. In the current study, continuous local field potential recordings from five rats were used to assess the changes in aspects of behavior and sleep, including wheel running activity, quiet wakefulness, motionless sleep, slow wave sleep, REM sleep, K-complexes and sleep spindles, in rats exposed to six consecutive days of a T21 light-dark cycle (L9:D12). Except for a temporal redistribution of sleep and activity during the T21, there were no changes in period, or total amount for any aspect of sleep or activity. These data suggest that the memory impairment elicited from 6 days of T21 exposure is likely not due to changes in sleep architecture. It remains possible that hippocampal plasticity is affected by experiencing light when subjective circadian phase is calling for dark. However, if there is a reduction in hippocampal plasticity, changes in sleep appear not to be driving this effect.

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Brief circadian rhythm disruption does not impair hippocampal dependent memory when rats are over-trained and given more re-entrainment days

Cited by 2 publications

References 52 publications

Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice

Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice

Assessment of Sleep, K-Complexes, and Sleep Spindles in a T21 Light-Dark Cycle

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