Brief Butyltin Exposure Induces Irreversible Inhibition of the Cytotoxic Function on Human Natural Killer Cells, In Vitro

Whalen, Margaret M.; Green, Stephanie A; Loganathan, Bommanna G.

doi:10.1006/enrs.2001.4318

Cited by 55 publications

(53 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The immunosuppressive action has been also demonstrated regarding other pollutants of environmental concern, such as cadmium (51), organotins (52), and organochlorines (53). Some investigations have demonstrated that cadmium does not seem to constitute a problem for coastal cetaceans in Brazil (54)(55)(56); however, the same could not be stated about organotins (42) and organochlorines (57).…”

Section: Resultsmentioning

confidence: 99%

High Accumulation of Perfluorooctane Sulfonate (PFOS) in Marine Tucuxi Dolphins (Sotalia guianensis) from the Brazilian Coast

Dorneles

Lailson‐Brito

Azevedo

et al. 2008

Environ. Sci. Technol.

View full text Add to dashboard Cite

Perfluorooctane sulfonate (PFOS) and other perfluoroalkyl compounds (PFCs) were measured in liver samples from 29 marine tucuxi dolphins from Rio de Janeiro state (RJ), Brazil. PFC measurement combined liquid chromatography and mass spectrometry, using a CapLC system connected to a Quadrupole-LIT mass spectrometer. PFOS was the only PFC detected and it was so in all samples. PFOS concentrations (ng · g -1 dw) of dolphins (n ) 23) from the highly contaminated Guanabara Bay (in RJ) varied between 43 and 2431 as well as between 76 and 427 from areas of RJ other than the quoted bay (n ) 6). Concentrations of three fetuses and one neonate varied between 664 and 1590. Fetus/mother ratios were calculated in two situations (2.75 and 2.62). It seems that mother-to-calf transference plays important role for relationships between PFOS and age. When a one-year-old male calf presenting 2431 ng · g -1 dw was excluded from the test, significant correlations were observed between PFOS concentrations and both age and total length. Despite the placental transference, PFOS concentrations were not significantly lower in females than in males. PFOS levels in marine tucuxi dolphins from Guanabara Bay are among the highest detected to date in cetaceans, and this may represent a threat to the small population concerned.

show abstract

Section: Resultsmentioning

confidence: 99%

High Accumulation of Perfluorooctane Sulfonate (PFOS) in Marine Tucuxi Dolphins (Sotalia guianensis) from the Brazilian Coast

Dorneles

Lailson‐Brito

Azevedo

et al. 2008

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Although many studies showed that these organotins disrupt immune functions in vivo (29,(53)(54)(55), some of the effects, such as the induction of T cell apoptosis, may be induced by rather high concentrations of the compounds (56). However, their effects on CCR9 expression and homing specificity of T cells could be exerted at nanomolar concentrations and might result in the perturbation of some immune responses.…”

Section: Discussionmentioning

confidence: 99%

Efficient Induction of CCR9 on T Cells Requires Coactivation of Retinoic Acid Receptors and Retinoid X Receptors (RXRs): Exaggerated T Cell Homing to the Intestine by RXR Activation with Organotins

Takeuchi

Yokota

Ohoka

et al. 2010

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…Our quantitative analysis of the number of gonocytes/unit area of the seminiferous tubules revealed a significant decrease only at a maternal dose of 10 mg/kg (days [8][9][10][11][12][13][14][15][16][17][18][19]. However, both doses and exposure periods resulted in a reduction in the numbers of Sertoli cells, an effect which could potentially reduce sperm production in adulthood.…”

Section: Discussionmentioning

confidence: 99%

“…Exposure of rodents to high doses of TBT appears to cause irreversible brain damage [12]. Immunotoxic effects of TBT include atrophy of the thymus and spleen, decreased T-lymphocyte populations, suppression of natural killer cell activity, and lowered resistance to infections in rats and mice [13][14][15]. TBT can also alter circulating levels of thyroid hormones suggesting that it can significantly alter many developmental processes that are thyroid-hormone dependant, including the reproductive system [16,17].…”

Section: Introductionmentioning

confidence: 99%

In utero exposure to tributyltin chloride differentially alters male and female fetal gonad morphology and gene expression profiles in the Sprague–Dawley rat

Kishta

Adeeko

et al. 2007

Reproductive Toxicology

View full text Add to dashboard Cite

Tributyltin (TBT) is an environmental contaminant commonly used in anti-fouling agents for boats, as well as a by-product from several industrial processes. It has been shown to accumulate in organisms living in areas with heavy maritime traffic thereby entering the food chain. Here, we determined the consequences of in utero exposure to TBT on the developing fetal gonads in the Sprague-Dawley rat. Timed pregnant rats were gavaged either with vehicle or TBT (0.25, 2.5, 10 or 20 mg/kg) from days 0 to 19 or 8 to 19 of gestation. On gestational day 20, dams were sacrificed; fetal testes and ovaries were processed for light (LM) or electron microscopic (EM) evaluation and RNA was prepared for gene expression profiling. At the highest doses of TBT the number of Sertoli cells and gonocytes was reduced, there were large intracellular spaces between Sertoli cells and gonocytes and there was an increased abundance of lipid droplets in the Sertoli cells; EM studies revealed abnormally dilated endoplasmic reticulum in Sertoli cells and gonocytes. In the intertubular region between adjacent interstitial cells, immunostaining for the gap junctional protein connexin 43 was strong in controls, whereas it was reduced or completely absent in treated rats. In the ovaries, TBT (20 mg/kg, days 0-19; 10 mg/kg, days 8-19) reduced the number of germ cells by 44% and 46%, respectively. On examining gene expression profiles in the testis, 40 genes out of 1176 tested were upregulated more than two-fold over control. While no genes were upregulated in the TBT exposed fetal ovary, eight genes were downregulated. In conclusion, in utero exposure to TBT resulted in gender-specific alterations in gonadal development and gene expression profiles suggesting that there may be different adaptive changes to toxicity in developing male and female rats.

show abstract

Brief Butyltin Exposure Induces Irreversible Inhibition of the Cytotoxic Function on Human Natural Killer Cells, In Vitro

Cited by 55 publications

References 41 publications

High Accumulation of Perfluorooctane Sulfonate (PFOS) in Marine Tucuxi Dolphins (Sotalia guianensis) from the Brazilian Coast

High Accumulation of Perfluorooctane Sulfonate (PFOS) in Marine Tucuxi Dolphins (Sotalia guianensis) from the Brazilian Coast

Efficient Induction of CCR9 on T Cells Requires Coactivation of Retinoic Acid Receptors and Retinoid X Receptors (RXRs): Exaggerated T Cell Homing to the Intestine by RXR Activation with Organotins

In utero exposure to tributyltin chloride differentially alters male and female fetal gonad morphology and gene expression profiles in the Sprague–Dawley rat

Contact Info

Product

Resources

About