Over 80% of the 1 billion people with disabilities in the world live in the Global South, yet, most of the research at the intersection of disability and technology published across HCI venues is based in the Global North. With limited published research, and a large range of socio-cultural, practical and environmental differences across the Global South, HCI researchers and practitioners can encounter unexpected challenges when planning and conducting accessibility studies. The aim of this panel is to bring together three experienced academics who have conducted, managed and published impactful HCI research working with people with disabilities in various regions of the Global South from Latin America to East Africa and South Asia. Panelists will give an initial overview of their experiences conducting research with participants who had different disabilities and other relevant stakeholders, dedicating particular attention to the practical aspects commonly involved in research projects.CCS CONCEPTS • Social and professional topics → People with disabilities • HCI Design and evaluation methods → Field Studies