Bridging research and clinical care – the comprehensive cancer centre

Oberst, Simon

doi:10.1002/1878-0261.12442

Cited by 20 publications

(19 citation statements)

References 9 publications

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“…The models of the infrastructures suggested above can be based on the structures of some existing networks and some key recommendations listed below. CCCs such as those accredited by the OECI [9], the German Cancer Aid [18], or CCCoEs designated by the EACS with focus on translational research [7] will be key components of the three infrastructures. These centres are well-positioned to form networks, both nationally and internationally, and some indeed have done so, both within and beyond national boundaries.…”

Section: Infrastructure Modelsmentioning

confidence: 99%

“…The latter goal emphasizes the need to create integrated, networked and geographically distributed infrastructures that can entail Comprehensive Cancer Centres of Excellence (CCCoEs) meeting the Excellence standards of the EACS [7], Comprehensive Cancer Centres accredited by the Organisation of European Cancer Institutes (OECI), cancer research and clinical centres and technological platforms. CCCs are crucial to establish closer links between research and healthcare systems [8,9]. By integrating cancer care and prevention with research and education, CCCoEs and CCCs are well-positioned to boost innovation and deliver state-of-the-art comprehensive multidisciplinary cancer care.…”

Section: Introductionmentioning

confidence: 99%

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Towards a cancer mission in Horizon Europe: recommendations

et al. 2020

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A comprehensive translational cancer research approach focused on personalized and precision medicine, and covering the entire cancer researchcare-prevention continuum has the potential to achieve in 2030 a 10-year cancer-specific survival for 75% of patients diagnosed in European Union (EU) member states with a well-developed healthcare system. Concerted actions across this continuum that spans from basic and preclinical research through clinical and prevention research to outcomes research, along with the establishment of interconnected high-quality infrastructures for translational research, clinical and prevention trials and outcomes research, will ensure that science-driven and social innovations benefit patients and individuals at risk across the EU. European infrastructures involving comprehensive cancer centres (CCCs) and CCC-like entities will provide researchers with access to the required critical mass of patients, biological materials and technological resources and can bridge research with healthcare systems. Here, we prioritize research areas to ensure a balanced research portfolio and provide recommendations for achieving key targets. Meeting these targets will require harmonization of EU and national priorities and policies, improved research coordination at the national, regional and EU level and increasingly efficient and flexible funding mechanisms. Long-term support by the EU and commitment of Member States to specialized schemes are also needed for the establishment and sustainability of trans-border infrastructures and networks. In addition to effectively engaging policymakers, all relevant stakeholders within the entire continuum should consensually inform policy through evidencebased advice.

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Section: Infrastructure Modelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Towards a cancer mission in Horizon Europe: recommendations

et al. 2020

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“…The Organisation of European Cancer Institutes (OECI) has launched an accreditation programme that permits cancer centres to assess their qualification as a comprehensive cancer centre (Saghatchian et al ., , Oberst ). The OECI programme has been a great success and has resulted in the assessment of around 50 comprehensive cancer centres in Europe.…”

Section: The Role Of Quality‐assured Research Environmentsmentioning

confidence: 99%

Quality‐assured research environments for translational cancer research

Berns

2019

Molecular Oncology

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In order to secure high‐quality cancer care for increasing numbers of cancer patients in the upcoming decades, the complete continuum of cancer research and cancer care needs a thorough overhaul, with more emphasis on prevention and early detection, and a greater focus on the development of innovative treatments that are also scrutinised for effectiveness and quality‐of‐life aspects. Therefore, under‐resourced research areas, such as primary prevention, early diagnosis/secondary prevention (Song et al ., 2018 ; Wild et al ., 2015 ) and outcomes research (Cavers et al ., 2017 ), should be given more emphasis, whereas basic, preclinical and clinical cancer research requires more innovation and effective collaboration to develop more effective treatments at an affordable cost. Innovative collaborative research in this translational trajectory requires the participation of well‐resourced and well‐organised institutions that are committed to high scientific and ethical standards. Offering focused funding to distinct segments of this research continuum concomitant with incentives to aspire to high‐quality standards is the most effective route to achieve these goals. Therefore, a rigorous quality assessment system for institutions operating in this research continuum is a high priority.

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“…Organisation of multidisciplinary cancer treatment/care, prevention, research and education and the concept of the CCC are ways to assure high‐quality research environments and to bridge the gap with the healthcare area (Oberst, ). OECI and German Cancer Aid provide educational activities on organisational aspects and offer methodologies to designate CCCs.…”

Section: Role Of Comprehensive Cancer Centres In Educationmentioning

confidence: 99%

Education aimed at increasing international collaboration and decreasing inequalities

Ernberg

2019

Molecular Oncology

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Educational initiatives in cancer research have to align with the needs of patients, individuals at risk, healthcare systems and public health organisations. The above interests demand strong translational interactions between basic research, clinical/prevention research and entrepreneurship. The resulting synergy between these three entities is expected to stimulate identification of unresolved issues in cancer biology, as well as unmet needs in diagnostics, treatment and prevention. It will also encourage the development of international research collaborations and, in turn, improve access to innovative research infrastructures. Education and dissemination of knowledge and technologies must be a cornerstone of any future European mission‐oriented approach to cancer, as it will ensure that new cancer treatments reach all patients within the European Union, and also help reduce gross inequalities in cancer incidence and mortality. A large number of educational institutions ranging from local universities to pan‐European organisations have developed excellent educational activities. However, a cancer mission will highlight additional roles for higher education that will complement and provide novel approaches. Educational and training activities should target the general public (dissemination) for primary cancer prevention, as well as the next generation of cancer researchers in basic and clinical research all over Europe. The experiences of patients are also needed to improve health‐related quality‐of‐life and outcomes research. A mission approach to cancer would enhance the exchange of researchers within Europe and worldwide, and prioritise collaborations between Western/Central and Eastern Europe countries. The Comprehensive Cancer Centres ( CCC s) will be crucial to train scientific staff in established centres as well as in candidate centres aspiring to join networks of CCC s. In addition, CCC s will have an important role to play by offering educational programmes for the next generation of clinical/research leaders.

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Bridging research and clinical care – the comprehensive cancer centre

Cited by 20 publications

References 9 publications

Towards a cancer mission in Horizon Europe: recommendations

Towards a cancer mission in Horizon Europe: recommendations

Quality‐assured research environments for translational cancer research

Education aimed at increasing international collaboration and decreasing inequalities

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