Bridging autoinflammatory and autoimmune diseases

Elshebiny, Emad; Zahran, Enas S.; Shoeib, Sabry; Habib, Eman S.

doi:10.1186/s43162-021-00040-5

Cited by 19 publications

(20 citation statements)

References 25 publications

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“…These conflicting hypotheses can be rationalized by considering that POTS has a “mixed” inflammatory signature. There are a number of recent reports in the literature providing evidence of mixed-pattern diseases [ 29 , 37 , 38 , 39 ]. We found that POTS patients had elevations of the proinflammatory cytokines IL-1β, IL-6, IL-18, and INFϒ, which have been reported in both autoinflammatory and autoimmune diseases and, potentially, are a result of abnormal NK cell function [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Platelet Storage Pool Deficiency and Elevated Inflammatory Biomarkers Are Prevalent in Postural Orthostatic Tachycardia Syndrome

Gunning

Kramer

Cichocki

et al. 2022

Cells

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A significant number of postural orthostatic tachycardia syndrome (POTS) patients have platelet delta granule storage pool deficiency (δ-SPD). The etiology of POTS is unknown but a number of laboratories, including ours, have reported elevations of G-protein-coupled adrenergic receptor and muscarinic acetylcholine receptor autoantibodies in POTS patients, detected by a variety of techniques, suggesting that the disorder is an autoimmune condition. Thus, it could also be considered an inflammatory disease. In a pilot study, we investigated a limited number of platelet-related cytokines and chemokines and discovered many that were elevated. This case–control study validates our pilot study results that POTS patients have an activated innate immune system. Plasma of 35 POTS patients and 35 patients with unexplained bleeding symptoms and categorized as “non-POTS” subjects was analyzed by multiplex flow cytometry to quantify 16 different innate immune system cytokines and chemokines. Electron microscopy was used to quantify platelet dense granules. Ten of 16 biomarkers of inflammation were elevated in plasma from POTS patients compared to non-POTS subjects, with most of the differences extremely significant, with p values < 0.0001. Of particular interest were elevations of IL-1β and IL-18 and decreased or normal levels of type 1 interferons in POTS patients, suggesting that the etiology of POTS might be autoinflammatory. All POTS patients had δ-SPD. With a growing body of evidence that POTS is an autoimmune disease and having elevations of the innate immune system, our results suggest a potential T-cell-mediated autoimmunity in POTS characteristic of a mixed-pattern inflammatory disease similar to rheumatoid arthritis.

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Section: Discussionmentioning

confidence: 99%

Platelet Storage Pool Deficiency and Elevated Inflammatory Biomarkers Are Prevalent in Postural Orthostatic Tachycardia Syndrome

Gunning

Kramer

Cichocki

et al. 2022

Cells

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“…The study on inflammatory response has continuously aroused renewed interest. It happens because there are many diseases in which much of the tissue damage results from the inflammatory response itself [ 9 , 10 ]. Autoimmune diseases fall into this category [ 8 ], as the conditions in which the local homeostatic capacity is overcome, either by the magnitude of the aggressive stimulus or by the insufficiency of regulatory mechanisms.…”

Section: Linking Inflammation To Autoimmunitymentioning

confidence: 99%

“Listen to Your Immune System When It’s Calling for You”: Monitoring Autoimmune Diseases Using the iShU App

Ortet

Costa

2022

Sensors

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The immune system plays a key role in protecting living beings against bacteria, viruses, and fungi, among other pathogens, which may be harmful and represent a threat to our own health. However, for reasons that are not fully understood, in some people this protective mechanism accidentally attacks the organs and tissues, thus causing inflammation and leads to the development of autoimmune diseases. Remote monitoring of human health involves the use of sensor network technology as a means of capturing patient data, and wearable devices, such as smartwatches, have lately been considered good collectors of biofeedback data, owing to their easy connectivity with a mHealth system. Moreover, the use of gamification may encourage the frequent usage of such devices and behavior changes to improve self-care for autoimmune diseases. This study reports on the use of wearable sensors for inflammation surveillance and autoimmune disease management based on a literature search and evaluation of an app prototype with fifteen stakeholders, in which eight participants were diagnosed with autoimmune or inflammatory diseases and four were healthcare professionals. Of these, six were experts in human–computer interaction to assess critical aspects of user experience. The developed prototype allows the monitoring of autoimmune diseases in pre-, during-, and post-inflammatory crises, meeting the personal needs of people with this health condition. The findings suggest that the proposed prototype—iShU—achieves its purpose and the overall experience may serve as a foundation for designing inflammation surveillance and autoimmune disease management monitoring solutions.

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“…Autoimmune diseases (AIDs) are caused by impairment of the immune system, which results in the production of antibodies against one's own tissues. This leads to clinical damage or impairment of their function [3]. At the time of the COVID-19 pandemic, patients affected by AIDs may be exposed to a more severe course of infection due to the failure of the immune system.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 and autoimmune diseases of the nervous system — an update

Morawiec

Adamczyk

Adamczyk-Sowa

2023

Neurol Neurochir Pol.

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Introduction. Due to a similar pathomechanism, COVID-19 infection may significantly affect the course of autoimmune diseases (AIDs). In our review, we aimed to assess the severity of SARS-CoV-2 infection, response to treatment, and the impact of COVID-19 infection on the course of the underlying disease in patients with neuroimmune diseases.State of the art. In the time of the COVID-19 pandemic, it was important to determine the influence of COVID-19 infection on the course of autoimmune diseases due to the weakened immune system and immunosuppressive therapies.Clinical implications. Many reports have indicated that in patients with AIDs, the existence of the disease is not associated with a worse prognosis in the course of the viral infection. Patients in advanced stages of the disease, elderly patients, and those with comorbidities are at risk of more frequent hospitalisations and higher mortality in the course of COVID-19. Moreover, some drugs used in AIDs have been tested for their efficacy in SARS-CoV-2 infection. Episodes of newly diagnosed myasthenia gravis, Guillain-Barré syndrome, acute disseminated encephalomyelitis (ADEM), and neuromyelitis optica spectrum disorder (NMOSD) secondary to COVID-19 or vaccination have also been reported. Vaccination against this pathogen is highly recommended in most patients with AIDs. Future directions. Despite many studies on the association between COVID-19 and neuroimmune diseases, more specific data is needed. The approach to patients with AIDs should be individual, since many issues remain unresolved despite the long-lasting pandemic.

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Bridging autoinflammatory and autoimmune diseases

Cited by 19 publications

References 25 publications

Platelet Storage Pool Deficiency and Elevated Inflammatory Biomarkers Are Prevalent in Postural Orthostatic Tachycardia Syndrome

Platelet Storage Pool Deficiency and Elevated Inflammatory Biomarkers Are Prevalent in Postural Orthostatic Tachycardia Syndrome

“Listen to Your Immune System When It’s Calling for You”: Monitoring Autoimmune Diseases Using the iShU App

COVID-19 and autoimmune diseases of the nervous system — an update

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