Bridged Biaryl Atropisomers by Organocatalyzed Kinetic Asymmetric Alcoholysis
Zhikang Wei,
Yi Zhao,
Tianyi Wang
et al.
Abstract:We disclose herein an asymmetric synthesis of axially chiral oxazepine-containing bridged biaryls via CPA-catalyzed kinetic asymmetric alcoholysis. Control experiments showed that this CPA-catalyzed alcoholysis was reversible, and lowering the reaction temperature could almost suppress the reversible reaction, thus providing a series of axially chiral oxazepine-containing bridged biaryl compounds in good to excellent enantioselectivities. The gram-scale reactions and facile derivatizations of the enantioenrich… Show more
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