BRG1 mediates epigenetic regulation of TNFα‐induced CCL2 expression in oral tongue squamous cell carcinoma cells
Mingyan Xu,
Xuemei Lu,
Feixiang Zhu
et al.
Abstract:Strong evidence has indicated that upregulation of chemokine (CC motif) ligand‐2 (CCL2) expression and the presence of an inflammatory tumor microenvironment significantly contribute to the migratory and invasive properties of oral squamous cell carcinoma, specifically oral tongue squamous cell carcinoma (OTSCC). However, the precise epigenetic mechanism responsible for enhanced CCL2 expression in response to the inflammatory mediator tumor necrosis factor alpha (TNF‐α) in OTSCC remains inadequately elucidated… Show more
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