Brevibacillus laterosporus inside the insect body: Beneficial resident or pathogenic outsider?

Marche, Maria Giovanna; Mura, Maria Consuelo; Ruiu, Luca

doi:10.1016/j.jip.2016.05.002

Cited by 23 publications

(18 citation statements)

References 19 publications

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“…Second, it can quickly establish and demonstrate defence responses in host plants ( Tian et al, 2006 ). And third, B. laterosporus can survive in various environmental stresses, such as UV light and desiccation, which allow for its natural formulation to be used for commercial purposes ( Marche et al, 2016 ), and this is a fundamental principle of biological control agents ( Tian et al, 2006 ). Regarding this aspect, the goal of this research is investigation of elicitor isolation and the exploitation of PeBL2 against devastating fungi.…”

Section: Discussionmentioning

confidence: 99%

A Novel Protein Elicitor PeBL2, from Brevibacillus laterosporus A60, Induces Systemic Resistance against Botrytis cinerea in Tobacco Plant

et al. 2019

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Section: Discussionmentioning

confidence: 99%

A Novel Protein Elicitor PeBL2, from Brevibacillus laterosporus A60, Induces Systemic Resistance against Botrytis cinerea in Tobacco Plant

et al. 2019

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“…Although the main trigger for EFB is the gram-positive microaerophilic Melissococcus plutonius (Forsgren, 2010;White, 1912) other bacteria, for example, Enterococcus faecalis, Paenibacillus alvei, Brevibacillus laterosporus, Bacillus pumilus, and Achromobacter euridice, have been shown to co-occur with EFB as the so-called secondary invaders (Erler, Denner, Bobiş, Forsgren, & Moritz, 2014;Forsgren, 2010). Whereas, M. plutonius is undoubtedly pathogenic and triggers EFB, P. alvei, B. pumilus, and A. euridice have also been identified as common bacterial species of the adult honeybee intestinal microflora (Gilliam, 1997) and B. laterosporus was detected in honeybee larvae, pupae, and foragers without being pathogenic (Marche, Mura, & Ruiu, 2016). However, besides the co-occurrence with M. plutonius, the role of the secondary invaders during EFB progress is not understood.…”

Section: Introductionmentioning

confidence: 99%

Food to some, poison to others - honeybee royal jelly and its growth inhibiting effect on European Foulbrood bacteria

et al. 2016

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Honeybee colonies (Apis mellifera) serve as attractive hosts for a variety of pathogens providing optimal temperatures, humidity, and an abundance of food. Thus, honeybees have to deal with pathogens throughout their lives and, even as larvae they are affected by severe brood diseases like the European Foulbrood caused by Melissococcus plutonius. Accordingly, it is highly adaptive that larval food jelly contains antibiotic compounds. However, although food jelly is primarily consumed by bee larvae, studies investigating the antibiotic effects of this jelly have largely concentrated on bacterial human diseases. In this study, we show that royal jelly fed to queen larvae and added to the jelly of drone and worker larvae, inhibits not only the growth of European Foulbrood‐associated bacteria but also its causative agent M. plutonius. This effect is shown to be caused by the main protein (major royal jelly protein 1) of royal jelly.

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“…B. laterosporus has been used as a bio control agent for decreasing the populations of unwanted bacteria and this method yielded modest results in attempts to control American Foulbrood [12,13]. While typically a symbiote to honeybees [14], B. laterosporus can produce toxins with insecticidal properties and certain strains of the bacterium are implicated in causing minor disease in honeybee hives after a primary infection [15,16,17,18]. The role of B. laterosporus as either a beneficial symbiote or as an opportunistic infector is yet to be fully understood.…”

Section: Introductionmentioning

confidence: 99%

Bystander Phage Therapy: Inducing Host-Associated Bacteria to Produce Antimicrobial Toxins against the Pathogen Using Phages

et al. 2018

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Brevibacillus laterosporus is often present in beehives, including presence in hives infected with the causative agent of American Foulbrood (AFB), Paenibacillus larvae. In this work, 12 B. laterosporus bacteriophages induced bactericidal products in their host. Results demonstrate that P. larvae is susceptible to antimicrobials induced from field isolates of the bystander, B. laterosporus. Bystander antimicrobial activity was specific against the pathogen and not other bacterial species, indicating that the production was likely due to natural competition between the two bacteria. Three B. laterosporus phages were combined in a cocktail to treat AFB. Healthy hives treated with B. laterosporus phages experienced no difference in brood generation compared to control hives over 8 weeks. Phage presence in bee larvae after treatment rose to 60.8 ± 3.6% and dropped to 0 ± 0.8% after 72 h. In infected hives the recovery rate was 75% when treated, however AFB spores were not susceptible to the antimicrobials as evidenced by recurrence of AFB. We posit that the effectiveness of this treatment is due to the production of the bactericidal products of B. laterosporus when infected with phages resulting in bystander-killing of P. larvae. Bystander phage therapy may provide a new avenue for antibacterial production and treatment of disease.

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Brevibacillus laterosporus inside the insect body: Beneficial resident or pathogenic outsider?

Cited by 23 publications

References 19 publications

A Novel Protein Elicitor PeBL2, from Brevibacillus laterosporus A60, Induces Systemic Resistance against Botrytis cinerea in Tobacco Plant

A Novel Protein Elicitor PeBL2, from Brevibacillus laterosporus A60, Induces Systemic Resistance against Botrytis cinerea in Tobacco Plant

Food to some, poison to others - honeybee royal jelly and its growth inhibiting effect on European Foulbrood bacteria

Bystander Phage Therapy: Inducing Host-Associated Bacteria to Produce Antimicrobial Toxins against the Pathogen Using Phages

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