Breeding for disease resistance ‐ the prospective role of genetic manipulation

Freeman, B. M.; Bumstead, Nat

doi:10.1080/03079458708436386

Cited by 4 publications

(1 citation statement)

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“…As we move into the era of feasibility of gene transfer in poultry (Salter & Crittenden 1988;Bosselman et al 1989), the importance of predicting the phenotypic expression of genes in diverse genetic backgrounds increases. A likely candidate for transfer is the major histocompatibility complex (MHC ;Freeman & Bumstead 1987;Warner et al 1987;Salter & Crittenden 1988;Hartmann 1988). Of especial interest in chickens is the B21 haplotype of the MHC, which has long been associated with resistance to Marek's disease, a neural lymphoma (e.g.…”

Section: Introductionmentioning

confidence: 99%

Marek's disease and major histocompatibility complex haplotypes in chickens selected for high or low antibody response

et al. 1989

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Sublines of chickens differing in genotypes at the major histocompatibility complex (MHC) were developed from lines selected for high (HA) and low (LA) antibody response to sheep erythrocytes. To evaluate the influence of MHC genotypes in diverse background genomes on resistance to Marek's disease, chicks with MHC genotypes B13B13, B13B21 and B21B21 from both background genomes were exposed naturally commencing at 1 day of age. Individuals which died up to 120 days of age were autopsied to determine cause of death. Mortality due to Marek's disease was greater for H A than LA chickens and greater for males than females. Interactions of MHC genotypes with background genome and with sex suggest a complex picture of the influence of MHC genotypes. A heterozygous advantage for resistance to Marek's disease was noted, as would be predicted by genetic theory concerning maintenance of polymorphism at the MHC.

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Section: Introductionmentioning

confidence: 99%

Marek's disease and major histocompatibility complex haplotypes in chickens selected for high or low antibody response

et al. 1989

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Gene insertion into the avian germline

Salter

Crittenden²

1988

BSAP Occas. Publ.

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Gene insertion into the avian germ line is reviewed. Useful pathogen-derived and animal-derived resistance genes that could be inserted into the avian germ line to convey resistance to pathogens are discussed. Methods of germ line insertion that have been successful in mice are summarized and their possible application in future avian germ line research are described. The successful transfer of retroviral genes into the chicken germ line using replication-competent recombinant retroviruses is summarized and several potentially useful transgenic chicken lines are described. The attempts to use one-round replication-defective retroviral vectors have been complicated by the detection of replication-competent retrovirus in chicks from injected eggs.

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Transgenic poultry: theory and practice

Freeman

Bumstead

1987

World's Poultry Science Journal

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Breeding for disease resistance ‐ the prospective role of genetic manipulation

Cited by 4 publications

References 109 publications

Marek's disease and major histocompatibility complex haplotypes in chickens selected for high or low antibody response

Marek's disease and major histocompatibility complex haplotypes in chickens selected for high or low antibody response

Gene insertion into the avian germline

Transgenic poultry: theory and practice

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