Breed‐specific variation of hematologic and biochemical analytes in healthy adult Bernese Mountain dogs

Nielsen, Lise Nikolic; Kjelgaard‐Hansen, Mads; Jensen, A. L.; Kristensen, Annemarie T.

doi:10.1111/j.1939-165x.2009.00186.x

Cited by 45 publications

(49 citation statements)

References 30 publications

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“…The clinical investigations did not identify any extracranial causes of the seizures in the 19 dogs, but an interesting finding was the mildly increased ALP activity observed in 12 dogs. This could indicate a breed‐associated increase in ALP activity in the PBGV as also seen in the Bernese Mountain Dog, and it is currently under further investigation …”

Section: Discussionmentioning

confidence: 86%

Epilepsy in the Petit Basset Griffon Vendeen: Prevalence, Semiology, and Clinical Phenotype

Gulløv

Toft

Baadsager

et al. 2011

Veterinary Internal Medicne

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Background: Epilepsy with a genetic background is increasingly being identified. In certain dog breeds, epilepsy occurs with a higher prevalence than the estimate of 1-2% reported in the general dog population.Hypothesis: The Petit Basset Griffon Vendeen (PBGV) experiences an increased occurrence of epilepsy compared to the general dog population.Animals: The target population consisted of all 876 PBGV dogs registered in the Danish Kennel Club from January 1, 1999 to December 31, 2008. The study population included 820 dogs that met the inclusion criteria.Methods: A population study was conducted to estimate the prevalence of epilepsy in the Danish PBGV population. A mailed questionnaire was used to detect possible signs of epilepsy. The information was subsequently validated by telephone interviews of positive and possible positive responders and a negative responder control group, using an extensive questionnaire developed to detect epilepsy. Dogs evaluated as epilepsy positive after the telephone interview were offered a clinical investigation.Results: The prevalence of epilepsy was estimated to be 8.9% (42/471) in the PBGV population. Average age of onset was 26.3 months. Sex and mode of response did not affect the prevalence, but a strong litter effect was seen. Among euthanized dogs, epilepsy was the predominant cause (6/45 = 13.3%).Conclusion and Clinical Importance: Petit Basset Griffon Vendeen dogs experience an increased risk of epilepsy characterized by a relatively early onset and dominated by focal seizures with and without secondary generalization. With an estimated prevalence of 8.9% and substantial clustering within litters, a genetic factor associated with epilepsy is suspected.

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Section: Discussionmentioning

confidence: 86%

Epilepsy in the Petit Basset Griffon Vendeen: Prevalence, Semiology, and Clinical Phenotype

Gulløv

Toft

Baadsager

et al. 2011

Veterinary Internal Medicne

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“…Lastly, the effect Data are presented as mean ± 95% Confidence Interval of dog breed on our values has not been factored. It has been reported that reference values for some biochemical parameters differ between dog breeds (Sharkey et al 2009;Mori et al 2010;Nielsen et al 2010). As such, it is important to consider breed during analysis.…”

Section: Discussionmentioning

confidence: 97%

Age-specific plasma biochemistry reference ranges in <1 year old dogs in Japan

et al. 2011

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The purpose of this study was to investigate and propose possible reference intervals of plasma biochemical analytes in young dogs (<12 months old) in Japan, using 896 canine plasma samples, collected from an array of veterinary clinics throughout the greater Tokyo metropolis area in Japan. The following biochemical parameters were assessed: albumin (ALB), alanine aminotransferase (ALT), alkaline phosphatase (ALP), amylase, aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine (CRE), glucose, lipase, total cholesterol (T-Cho), and total protein (TP) were evaluated. Multivariate linear regression analysis indicated that partitioning according to age or gender may be necessary for some plasma analytes. Age appeared to significantly affect ALB, ALT, ALP, BUN, Glucose, Lipase, and Total Protein (P= <0.001, <0.001, <0.001, 0.013, <0.001, 0.025, and <0.001, respectively). On the other hand, gender significantly influenced ALP, Amylase, Lipase, and T-Cho levels (P=0.017, <0.001, <0.001, and <0.001, respectively) whereas it may be borderline significant with ALT (P=0.072).

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“…Greyhound‐specific RI, however, should be considered as proof of the need for breed‐specific RI in dogs. The decision to partition data according to breed could indeed be valid both for sighthounds and also other breeds, as suggested recently . This issue is not only pertinent to dogs: a genetic basis and need for breed‐dependent partitioning have been demonstrated in cats .…”

mentioning

confidence: 98%

Greyhound‐specific reference intervals: a good start to a long race

Lefebvre¹

2011

Veterinary Clinical Pathol

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Breed‐specific variation of hematologic and biochemical analytes in healthy adult Bernese Mountain dogs

Cited by 45 publications

References 30 publications

Epilepsy in the Petit Basset Griffon Vendeen: Prevalence, Semiology, and Clinical Phenotype

Epilepsy in the Petit Basset Griffon Vendeen: Prevalence, Semiology, and Clinical Phenotype

Age-specific plasma biochemistry reference ranges in <1 year old dogs in Japan

Greyhound‐specific reference intervals: a good start to a long race

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