Breed predisposition to canine gastric carcinoma - a study based on the Norwegian canine cancer register

Seim-Wikse, Tonje; Jörundsson, Einar; Nødtvedt, Ane; Grotmol, Tom; Bjørnvad, Charlotte Reinhard; Kristensen, Annemarie T.; Skancke, Ellen

doi:10.1186/1751-0147-55-25

Cited by 30 publications

(40 citation statements)

References 18 publications

(59 reference statements)

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“…According to a recent Norwegian survey, canine GC accounts for only 0.16% of all reported canine cancer cases . This is in accordance with earlier reports in which GC cases accounted for less than 1% of all canine tumours .…”

Section: Clinical Presentation Of Gcsupporting

confidence: 87%

“…The overall prevalence of gastric carcinoma (GC) in dogs is low although, in a small number of breeds, a higher incidence has been reported . This multi‐practice Norwegian study is the only current study comparing the relative in‐breed morbidity of gastric cancer.…”

Section: Introductionmentioning

confidence: 97%

“…Similar to human GC, the aetiology of canine GC is complex and poorly understood, but it is believed that both environmental and genetic factors play a role . Long‐term administration of N‐Nitrosamines can lead to induction of GC, although the relevance of this in clinical settings in unclear .…”

Section: Introductionmentioning

confidence: 99%

“…Long‐term administration of N‐Nitrosamines can lead to induction of GC, although the relevance of this in clinical settings in unclear . The strong breed predisposition and familial occurrence described for several canine breeds, including the Belgian Shepherd dog, indicate the importance of genetic factors in the aetiology of gastric cancer . In addition, some very small subgroups of canine gastric cancer may have different aetiologies.…”

Section: Introductionmentioning

confidence: 99%

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Gastric carcinoma in canines and humans, a review

Hugen

Thomas

German

et al. 2016

Vet Comparative Oncology

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Gastric carcinoma (GC) is the most common neoplasm in the stomach of dogs. Although incidence in the general population is reported to be low, breed-specific GC has a high incidence. Median age at presentation ranges from 8 to approximately 10 years. The disease is mostly located in the lesser curvature and antropyloric region of the stomach. Unfortunately, diagnosis is usually made when the disease is at an advanced stage and, therefore, prognosis is poor. Due to similarities in clinical presentation, diagnosis, histology and prognosis, canine GC may serve as a valuable model for human GC. Extensive pedigrees of canine gastric carcinoma cases could reveal insights for human gastric carcinoma. Putative species differences include the role of Helicobacter in pathogenesis, the wide array of genetic data and screening available for humans, and treatment protocols that are available for human GC.

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Section: Clinical Presentation Of Gcsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gastric carcinoma in canines and humans, a review

Hugen

Thomas

German

et al. 2016

Vet Comparative Oncology

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“…In dogs, adenocarcinoma is the most common type of gastric malignancy, accounting for 70%–80% of cases . A report of a recent study in which the Norwegian canine cancer registry was used described a prevalence of 0.16% for canine gastric carcinoma …”

Section: Introductionmentioning

confidence: 99%

Perioperative complications and outcome after surgery for treatment of gastric carcinoma in dogs: A Veterinary Society of Surgical Oncology retrospective study of 40 cases (2004–2018)

et al. 2019

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Objective: To describe the clinical characteristics, perioperative complications, and outcomes in dogs surgically treated for gastric carcinoma. Study design: Multi-institutional retrospective case series. Animals: Forty client-owned dogs with histologically confirmed gastric carcinoma.Methods: Medical records were reviewed for preoperative diagnostics, surgery, histopathology, postoperative complications, adjuvant chemotherapy, disease progression, and survival. Variables were assessed for associations with outcome by using Cox proportional hazards regression analysis. Results: Surgical treatment included partial gastrectomy (28 dogs), Billroth I (9 dogs), subtotal gastrectomy (2 dogs), and submucosal resection (1 dog). Major postoperative complications occurred in 8 of 40 dogs, including septic peritonitis secondary to dehiscence in 4 dogs. The median progression free interval was 54 days, and the median survival time (MST) was 178 days (range, 1-1902). According to multivariable analysis results, experiencing an intraoperative complication was associated with an increased risk of death (hazard ratio [HR] 3.5, 95% CI 1.1-9.8, P = .005), and administration of adjuvant chemotherapy correlated with an improved survival (HR 0.4, 95% CI 0.2-0.9, P = .03). Conclusion: In this population of dogs, MST exceeded historically reported data, major postoperative complication rates were comparable to established literature, and administration of adjuvant chemotherapy was associated with improved survival.

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