Breed, gender and age pattern of diagnosis for veterinary care in insured dogs in Japan during fiscal year 2010

Inoue, Mai; Hasegawa, Atsuhiko; Hosoi, Yosuke; Sugiura, Katsuaki

doi:10.1016/j.prevetmed.2015.02.010

Cited by 28 publications

(41 citation statements)

References 16 publications

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“…The increased risk of intestinal T‐cell lymphoma in those breeds has not been previously reported. Of the total insured dog population in Japan, Shiba dogs are the 4th most popular breed . The highest OR in Shiba dogs in the current study may partly correlate with the popularity of this breed in the total population.…”

Section: Discussionmentioning

confidence: 56%

“…are the 4th most popular breed. 9 The highest OR in Shiba dogs in the current study may partly correlate with the popularity of this breed in the total population. It also needs to be emphasized that there is a possible selection bias because the study population was predominantly composed of referral cases from secondary hospitals.…”

Section: Survivalmentioning

confidence: 63%

“…It also needs to be emphasized that there is a possible selection bias because the study population was predominantly composed of referral cases from secondary hospitals. Little information on the total population at risk of intestinal T‐cell lymphoma may have affected the result in this study . Boxers and Shar‐pei, the breeds overrepresented in gastrointestinal lymphoma in a previous study, were not included in the 43 breeds.…”

Section: Discussionmentioning

confidence: 99%

“…Little information on the total population at risk of intestinal T-cell lymphoma may have affected the result in this study. 9 Boxers and Shar-pei, the breeds overrepresented in gastrointestinal lymphoma in a previous study, 8,10 were not included in the 43 breeds. This can be explained by geographical variation in breed distribution and breed popularity in the normal population.…”

Section: Survivalmentioning

confidence: 99%

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Pathological features of intestinal T‐cell lymphoma in Shiba dogs in Japan

Matsumoto

Uchida

Nakashima

et al. 2018

Vet Comparative Oncology

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Intestinal T-cell lymphoma is being more frequently diagnosed in dogs owing to the wide availability of endoscopy and clonality analysis in veterinary medicine. However, no epidemiological study on intestinal T-cell lymphoma has been previously performed, and hence, information about dog breed, age and sex distributions of intestinal T-cell lymphoma has largely remained unclear. In this study, breed predisposition to canine intestinal T-cell lymphoma was determined by calculating odds ratios and 95% confidential intervals. Of the 43 breeds identified, 7 appeared to have an increased risk of developing intestinal T-cell lymphoma, including Shiba dogs, German shepherds, Cairn terriers, Boston terriers, Papillons, Pugs and Maltese. Immunohistochemistry of representative Shiba cases revealed ubiquitous cytotoxic immunophenotype in both large and small cell lymphomas. Interestingly, CD20 co-expression was observed in 11% of cases. It could potentially be aberrant expression of CD20 or neoplastic transformation of a normal subset of CD20-positive T-cells. A comparison of mean age between representative breeds revealed that Shiba dogs were slightly younger than Miniature Dachshunds (P < .05). However, there was no difference in survival between the 2 breeds. As Shiba dogs are predisposed to chronic enteropathy, there may be underlying inflammatory process contributing to lymphomagenesis of intestinal T-cell lymphoma in this breed. Our findings provide insights into the underlying pathogenesis of breed-specific canine intestinal T-cell lymphoma.

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Section: Discussionmentioning

confidence: 56%

Section: Survivalmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Survivalmentioning

confidence: 99%

See 2 more Smart Citations

Pathological features of intestinal T‐cell lymphoma in Shiba dogs in Japan

Matsumoto

Uchida

Nakashima

et al. 2018

Vet Comparative Oncology

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“…In North America, FB was the 6th most popular breed in the United States in 2014 [3], and the 9th most popular breed in Canada in 2015 [4]. Due to the brachycephalic and chondrodystrophic body conformation resulting from selective inbreeding, a high prevalence of various diseases has been described in this breed, including several neurological conditions [5]. These include not only myelopathies such as compressive vertebral malformations [6], spinal arachnoid diverticula [7] and intervertebral disc disease [8], but also encephalopathies such as brain tumours [9] or non-infectious encephalitides [10].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of neurological disorders in French bulldog: a retrospective study of 343 cases (2002–2016)

et al. 2017

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BackgroundFrench Bulldog (FB) has significantly gained in popularity over the last few years, and seems to be frequently affected by various neurological conditions. The purpose of this retrospective study was to report the prevalences of neurological diseases in a large population of FB, presented with neurological signs between 2002 and 2016, and for which a definitive diagnosis was established. A secondary objective was to identify epidemiological characteristics regarding specific diseases in this singular breed.ResultsDuring the study period, 533 FBs were presented for neurological signs, representing 18.7% of all admitted FBs (N = 2846). In total, 343 FBs with definitive diagnosis were included in this descriptive epidemiological study. Hansen type I intervertebral disk herniation (IVDH) was by far the most common neurological disorder (45.5% of all cases). The IVDH location was cervical in 39.8%, and thoracolumbar in 60.2% of cases. The median ages for cervical and thoracolumbar IVDH were 4.2 and 4 years, respectively. C3-C4 was the most commonly affected disk (57.8% of cervical IDVH) all locations combined. Spinal arachnoid diverticulum (SAD) was detected in 25 FBs, representing the second most common myelopathy (11.3%). A concurrent spinal abnormality was identified in 64.0% of SAD cases. Brain tumours represented 36.8% of encephalopathies, with glioma (confirmed or suspected) being the most common. Meningoencephalitis of unknown origin (MUO) represented 25.0% of brain disorders, females less than 5.5 years being more likely to be affected. Aside from central nervous system conditions, otitis interna associated with peripheral vestibular signs and bilateral congenital deafness (associated with white coat) were also common.ConclusionsThe findings of this study suggest that FB seems to be prone to several neurological diseases. IVDH is clearly predominant in FB and cervical location seems more represented than in other breeds. FBs affected by IVDH tend to be younger than previously described, either for both cervical and thoracolumbar locations. Thoracic SAD was the second most common myelopathy, with a concurrent spinal anomaly identified in two thirds of the cases. MUO was more likely to affect young to middle-aged females. These findings could be of interest for owners, breeders, practicing veterinarians and insurance companies.

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References

2018

Veterinary Epidemiology

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Breed, gender and age pattern of diagnosis for veterinary care in insured dogs in Japan during fiscal year 2010

Cited by 28 publications

References 16 publications

Pathological features of intestinal T‐cell lymphoma in Shiba dogs in Japan

Pathological features of intestinal T‐cell lymphoma in Shiba dogs in Japan

Prevalence of neurological disorders in French bulldog: a retrospective study of 343 cases (2002–2016)

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