Breed Differences on the Plasma Availability of Moxidectin Administered Pour-on to Calves

Sallovitz, Juan Manuel; Lifschitz, Adrián Luis; Imperiale, F.; Pis, A.; Virkel, G.; Lanusse, Carlos

doi:10.1053/tvjl.2002.0715

Cited by 55 publications

(55 citation statements)

References 20 publications

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“…Routes of administration have a great effect on pharmacokinetic behavior and efficacy of an endectocide (Steel, 1993;Herd et al, 1996;Vercruysse and Rew, 2002). It was also found that higher C max of ivermectin and moxidectin in cattle was obtained after oral administration than topical administration (Miller et al, 1994;Sallovitz et al, 2002;Gayrard et al, 1999). In the present study, the similar AUC of eprinomectin in plasma in both groups (98.46 ± 24.75 and 91.00 ± 25.32 ng d ml −1 ) would contribute to a similar clinical efficacy, since efficacy mainly depended on AUC (Rowland and Tozer, 1995).…”

Section: Discussionmentioning

confidence: 99%

Plasma and milk kinetics of eprinomectin following topical or oral administration to lactating Chinese Holstein cows

Wen

Pan

Wang

et al. 2010

Veterinary Parasitology

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Section: Discussionmentioning

confidence: 99%

Plasma and milk kinetics of eprinomectin following topical or oral administration to lactating Chinese Holstein cows

Wen

Pan

Wang

et al. 2010

Veterinary Parasitology

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“…In cattle, breed and race differences in drug kinetics have been reported in the past (Ndong et al, 2005;Sallovitz et al, 2002). Important differences in the pattern of systemic availability of moxidectin after topical administration have been observed between Aberdeen Angus and Holstein breeds (Sallovitz et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Several factors, such www.elsevier.com/locate/vetpar Available online at www.sciencedirect.com Veterinary Parasitology 152 (2008) [136][137][138][139][140] as animal species, level of feed intake and body composition, have been shown to affect the systemic availability of ivermectin substantially (Hennesy and Alvinerie, 2002) in both sheep and cattle. Moreover, important differences have been observed between the pattern of absorption and systemic availability of another ML -moxidectin -following topical administration in cattle of two different breeds, Aberdeen Angus and Holstein (Sallovitz et al, 2002). It has also been shown that the availability of ivermectin after subcutaneous injection is low in zebu Gobra cattle (Bos indicus) in comparison to other taurine (Bos taurus) breeds of cattle (Ndong et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Breed differences in the pharmacokinetics of ivermectin administered subcutaneously to Holstein and Belgian Blue calves

Vercruysse

Deprez

Everaert

et al. 2008

Veterinary Parasitology

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Belgian Blue (BB) cattle are very sensitive to mange caused by Psoroptes ovis and, in contrast to the case in Holstein cattle, single treatments with ivermectin do not result in complete elimination of the parasite. The objective of the present study was to determine the concentration of ivermectin in plasma, skin and hair following subcutaneous administration to Holstein and BB calves and to assess the influence of breed on drug pharmacokinetics and availability. Two groups of six healthy female Holstein and BB calves were treated with ivermectin (SC formulation) at a dose of 0.2 mg/kg. Blood, skin and hair were collected before treatment and up to 21 days after treatment. Ivermectin was analyzed in plasma and tissue by high-performance liquid chromatography (HPLC). The peak concentrations (C max ), time-peak concentrations (T max ), the area under the plasma concentration-time curves (AUC) and the mean residence time (MRT) were determined. The patterns of plasma and tissue ivermectin concentrations were similar in the two breeds of animals, however, the AUC and C max levels for plasma and skin were significantly higher in the BB calves. In hair, ivermectin was detected later than in plasma and skin, with the T max ranging between 4 days (Holstein group) and 6 days (BB group). The possible reasons for the significantly higher levels in plasma and skin in BB calves compared to Holstein calves are discussed. #

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“…Differences in DME expression are likely to influence both the bioavailability and clinical efficacy of xenobiotics (Sallovitz et al, 2002), and these same might be of particular concern in farm animals, for the hypothetical presence of potentially harmful residues in foodstuffs of animal origin. Moreover, the presence of uneven results suggests that such an effect cannot be clearly set at the level of enzyme translation rather than transcription a priori.…”

Section: Effect Of Breed Upon Drug-metabolizing Enzymes In Cattlementioning

confidence: 99%

Effect of Breed upon Cytochromes P450 and Phase II Enzyme Expression in Cattle Liver

Giantin¹,

Carletti²,

Capolongo³

et al. 2008

Drug Metab Dispos

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ABSTRACT:Cattle represent an important source of animal-derived foodproducts; nonetheless, our knowledge about the expression of drug-metabolizing enzymes (DMEs) in present and other foodproducing animals still remains superficial, despite the obvious toxicological consequences. Breed represents an internal factor that modulates DME expression and catalytic activity. In the present work, the effect of breed upon relevant phase I and phase II DMEs was investigated at the pretranscriptional and post-translational levels in male Charolais (CH), Piedmontese (PM) and Blonde d'Aquitaine (BA) cattle. Because specific substrates for cattle have not yet been identified, the breed effect upon specific cytochrome P450 (P450), UDP-glucuronosyltransferase (UGT), or glutathione S-transferase (GST) DMEs, in terms of catalytic activity, was determined by using human marker substrates. Among P450s, benzphetamine N-demethylase, 16␤-, 6␤-, and 2␤-testosterone hydroxylase, aniline and p-nitrophenol hydroxylase, and ␣-naphthol and p-nitrophenol UGT activities were significantly higher in CH; in contrast, lower levels of CYP1A1-, CYP1A2-, CYP2B6-, CYP2C9-, CYP2C18-, CYP3A4-, and UGT1A1-like mRNAs were noticed, with CH < PM < BA as a trend. CYP2B and CYP3A mRNA results were confirmed with immunoblotting, too. As regards conjugative DMEs, UGT1A6-like mRNA levels were consistent with respective catalytic activities. Both 1-chloro-2,4-dinitrobenzene and 3,4-dichloronitrobenzene GST activities were higher in BA, and these results agreed with GSTA1-, GSTM1-, and GSTP1-like mRNA amounts. Correlation analysis between catalytic activities and mRNAs showed either significant or uneven results, depending on the substrate. These findings confirm previous data obtained in laboratory species; however, further studies are required to ascribe this behavior to pretranscriptional or post-translational phenomena.Historically, studies concerning drug-metabolizing enzyme (DME) expression and regulation in veterinary food-producing species (e.g., cattle, swine, poultry) have always been considered of lesser interest, if compared with those done in man and laboratory animals. This is rather peculiar. Basically, the DMEs comparative knowledge is useful either to extrapolate pharmacotoxicological data from one species to another or to extend veterinary drug licenses of use from major to minor or exotic species. On the other hand, farm animals are often exposed to pesticides, pollutants, or drugs (sometimes used illicitly to increase growth performances), which are potentially harmful for the animal itself and also for humans, if the consumption of animal edible tissues containing relevant amounts of residues occurs. Consequently, drug metabolism studies, performed in these animals, are of value for the evaluation of the consumer's risk (Sivapathasundaram et al., 2001, This study was supported by the Università degli Studi di Padova (Grants 60A08-8213/05, Studi sull'espressione degli enzimi farmaco-metabolizzanti nel fegato di bovini appartenenti a razze dive...

show abstract

Breed Differences on the Plasma Availability of Moxidectin Administered Pour-on to Calves

Cited by 55 publications

References 20 publications

Plasma and milk kinetics of eprinomectin following topical or oral administration to lactating Chinese Holstein cows

Plasma and milk kinetics of eprinomectin following topical or oral administration to lactating Chinese Holstein cows

Breed differences in the pharmacokinetics of ivermectin administered subcutaneously to Holstein and Belgian Blue calves

Effect of Breed upon Cytochromes P450 and Phase II Enzyme Expression in Cattle Liver

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