Breath Testing for SARS CoV-2 Infection

Myers, Renelle; Ruszkiewicz, Dorota; Meister, Austin; Bartolomeu, Crista; Atkar-Khattra, Sukhinder; Thomas, Paul D.; Lam, Stephen

doi:10.2139/ssrn.4238643

SSRN Journal

2022

DOI: 10.2139/ssrn.4238643

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Breath Testing for SARS CoV-2 Infection

Renelle Myers

Dorota Ruszkiewicz

Austin Meister

et al.

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2024

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“…Recently, different methods have been used for analysis of exhaled breath or exhaled breath condensate to detect COVID-19, such as gas chromatography-mass spectrometry (GC-MS) 9,10 , proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) [11][12][13] , Fourier transform infrared spectroscopy (FTIR) 14 , gas chromatography-ion mobility spectrometry (GC-IMS) 15,16 , sensors and electronic nose 17,18 , and others 19,20 . In April 2022, the US Food and Drug Administration approved the first COVID-19 screening test by GC-MS analysis of breath samples under emergency use authorization (EUA) 21 .…”

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Detection of COVID-19 by quantitative analysis of carbonyl compounds in exhaled breath

Xie,

Morris,

Pan

et al. 2024

Sci Rep

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COVID-19 has caused a worldwide pandemic, creating an urgent need for early detection methods. Breath analysis has shown great potential as a non-invasive and rapid means for COVID-19 detection. The objective of this study is to detect patients infected with SARS-CoV-2 and even the possibility to screen between different SARS-CoV-2 variants by analysis of carbonyl compounds in breath. Carbonyl compounds in exhaled breath are metabolites related to inflammation and oxidative stress induced by diseases. This study included a cohort of COVID-19 positive and negative subjects confirmed by reverse transcription polymerase chain reaction between March and December 2021. Carbonyl compounds in exhaled breath were captured using a microfabricated silicon microreactor and analyzed by ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS). A total of 321 subjects were enrolled in this study. Of these, 141 (85 males, 60.3%) (mean ± SD age: 52 ± 15 years) were COVID-19 (55 during the alpha wave and 86 during the delta wave) positive and 180 (90 males, 50%) (mean ± SD age: 45 ± 15 years) were negative. Panels of a total of 34 ketones and aldehydes in all breath samples were identified for detection of COVID-19 positive patients. Logistic regression models indicated high accuracy/sensitivity/specificity for alpha wave (98.4%/96.4%/100%), for delta wave (88.3%/93.0%/84.6%) and for all COVID-19 positive patients (94.7%/90.1%/98.3%). The results indicate that COVID-19 positive patients can be detected by analysis of carbonyl compounds in exhaled breath. The technology for analysis of carbonyl compounds in exhaled breath has great potential for rapid screening and detection of COVID-19 and for other infectious respiratory diseases in future pandemics.

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mentioning

confidence: 99%

Detection of COVID-19 by quantitative analysis of carbonyl compounds in exhaled breath

Xie,

Morris,

Pan

et al. 2024

Sci Rep

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Breath Testing for SARS CoV-2 Infection

Cited by 1 publication

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Detection of COVID-19 by quantitative analysis of carbonyl compounds in exhaled breath

Detection of COVID-19 by quantitative analysis of carbonyl compounds in exhaled breath

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