Breath-hold 3D gradient-echo MR imaging of the lung parenchyma: Evaluation of reproducibility of image quality in normals and preliminary observations in patients with disease

Semelka, Richard C.; Balci, N. Cem; Wilber, Kathy; Fisher, Laurie; Brown, Mark; Gomez-Caminero, Andres; Molina, Paul L.

doi:10.1002/(sici)1522-2586(200002)11:2<195::aid-jmri18>3.0.co;2-q

Cited by 47 publications

(36 citation statements)

References 15 publications

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“…Vogt et al [27] compared HF-FSE MRI to conventional chest radiography and revealed a sensitivity for nodules 5-10 mm of 94.9% and 97.4% for nodules >11 mm using HF-FSE MRI. Semelka et al [28] assessed a nodular detection threshold of 3 mm using a 3D-GRE protocol similar to the one used in our study.…”

Section: Discussionmentioning

confidence: 99%

Detection of small pulmonary nodules in high-field MR at 3 T: evaluation of different pulse sequences using porcine lung explants

Regier¹,

Kandel

Kaul³

et al. 2006

Eur Radiol

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To evaluate two MR imaging sequences for the detection of artificial pulmonary nodules inside porcine lung explants. 67 agarose nodules ranging 3-20 mm were injected into ten porcine lungs within a dedicated chest phantom. The signal on T1-weighted images and radiopacity were adjusted by adding 0.125 mmol/l Gd-DTPA and 1.5 g/l of iodine. A T1-weighted three-dimensional gradient-echo (T1-3D-GRE; TR/TE:3.3/1.1 ms, slice:8 mm, flip-angle:10 degrees ) and a T2-weighted half-Fourier fast-spin echo sequence (T2-HF-FSE; TR/TE:2000/66 ms, slice:7 mm, flip-angle:90 degrees ) were applied in axial orientation using a 3-T system (Intera, Philips Medical Systems, Best, The Netherlands), followed by CT (16x0.5 mm) as reference. Nodule sizes and locations were assessed by three blinded observers. In nodules of >10 mm, sensitivity was 100% using 3D-GRE-MRI and 94% using the HF-FSE sequence. For nodules 6-10 mm, the sensitivity of MRI was lower than with CT (3D-GRE:92%; T2-HF-FSE:83%). In lesions smaller than 5 mm, the sensitivity declined to 80% (3D-GRE) and 53% (HF-FSE). Small lesion diameters were overestimated with both sequences, particularly with HF-FSE. This study confirms the feasibility of 3 T-MRI for lung nodule detection. In lesions greater than 5 mm, the sensitivity of the 3D-GRE sequence approximated CT (>90%), while sensitivity and PPV with the HF-FSE sequence were slightly inferior.

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Section: Discussionmentioning

confidence: 99%

Detection of small pulmonary nodules in high-field MR at 3 T: evaluation of different pulse sequences using porcine lung explants

Regier¹,

Kandel

Kaul³

et al. 2006

Eur Radiol

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“…Images from patients referred for abdominal MRI clearly delineated the mediastinum and the lower parts of the lung, as far as they were covered. These results already suggested, that a high imaging quality and negligible image artifacts could be expected [13].…”

Section: Discussionmentioning

confidence: 99%

“…The overall imaging quality was at least comparable to 2D-GRE studies of the lung [2 ± 4,16]. Ghosting artifacts from cardiac and vessel pulsation, which are generally very strong on coronal 2D-GRE images, were absent or only moderate on our 3D-GRE (VIBE) series [13,16]. Pre-saturation pulses to suppress the influence from moving mediastinal structures -sometimes used for 2D-GRE protocols requiring additional imaging time [16] ± were not necessary.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging of the lung with a volumetric interpolated 3D-Gradient echo sequence

Biederer

Graessner²,

Heller³

2001

Fortschr Röntgenstr

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Summary. Objective: To evaluate the feasibility of a magnetic resonance imaging protocol for the lung using a volumetric interpolated 3D-gradient echo sequence (3D-GRE). Subjects and Methods: AT 1 -weighted 3D-GRE sequence was used for volumetric interpolated breath-hold examinations (ªVIBEº) of the lung in twelve healthy volunteers (TR/TE 4.5/1.9 ms, flip-angle 128, matrix 502 512 [interpolated]). Three coronal 80 mm slabs (16 partitions, 2.5 mm slices) were added to 3D data sets for multi-planar reformations. No contrast material was applied. Artifacts and resolution of vessel and airway structures in each lung segment were evaluated by two observers (12 volunteers, 228 lung segments). Results: The protocol provided excellent images of vascular and tracheo-bronchial structures with very moderate pulsation artifacts. 224/228 lung segments were imaged with ªgoodº (146/228) or ªsufficientº quality (78/ 228). Segmental and sub-segmental vessels (5 th order) were identified due to bright flow signal without administration of contrast material. Walls of segmental bronchi (3 rd order) were delineated in all parts of the lung. Conclusions: The high spatial resolution, the excellent visualization of lung anatomy, the low rate of artifacts without respiratory triggering and the short acquisition times are clear advantages of the 3D-GRE (VI-BE) sequence compared to existing 2D-GRE strategies for MRI of the lung.Key words: MRI ± Lung ± Volume interpolation ± Breath-hold examination Magnetresonanztomographie der Lunge mit einer volumeninterpolierten 3D-Gradientenechosequenz. Ziel: Bewer-

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“…Gadolinium-enhanced images are also necessary for MR assessment of the lungs. The 3D gradientecho T1-weighted sequence with fat suppression used in this protocol show diminished phase artifact in the retrocardiac region in comparison to two-dimensional gradient-echo T1-weighted images, allowing for better evaluation of all portions of the lung (14,17,25) . The pulmonary vasculature can also be evaluated with this sequence because of its high spatial resolution, which enables high-quality multiplanar reconstruction.…”

Section: B a C Dmentioning

confidence: 99%

Whole-body MRI: comprehensive evaluation on a 48-channel 3T MRI system in less than 40 minutes. Preliminary results

Hernandes¹,

Semelka²,

Júnior

et al. 2012

Radiol Bras

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Objective: To evaluate a comprehensive MRI protocol that investigates for cancer, vascular disease, and degenerative/ inflammatory disease from the head to the pelvis in less than 40 minutes on a new generation 48-channel 3T system. Materials and Methods: All MR studies were performed on a 48-channel 3T MR scanner. A 20-channel head/neck coil, two 18-channel body arrays, and a 32-channel spine array were employed. A total of 4 healthy individuals were studied. The designed protocol included a combination of single-shot T2-weighted sequences, T1-weighted 3D gradientecho pre-and post-gadolinium. All images were retrospectively evaluated by two radiologists independently for overall image quality. Results: The image quality for cancer was rated as excellent in the liver, pancreas, kidneys, lungs, pelvic organs, and brain, and rated as fair in the colon and breast. For vascular diseases ratings were excellent in the aorta, major branch vessel origins, inferior vena cava, portal and hepatic veins, rated as good in pulmonary arteries, and as poor in the coronary arteries. For degenerative/inflammatory diseases ratings were excellent in the brain, liver and pancreas. The inter-observer agreement was excellent. Conclusion: A comprehensive and time efficient screening for important categories of disease processes may be achieved with high quality imaging in a new generation 48-channel 3T system. Keywords: Whole-body MRI; Screening; Protocol; Preliminary results; 3 tesla.Objetivo: Avaliar protocolo de RM para investigação de neoplasia, doenças vascular e degenerativa/inflamatória da cabeça à pelve em menos de 40 minutos em equipamento 3T com 48 canais. Materiais e Métodos: Todos os exames foram realizados em equipamento 3T com 48 canais. Foram utilizadas bobinas de cabeça/pescoço (20 canais), duas de corpo interligadas (18 canais) e uma de coluna (32 canais). Quatro voluntários saudáveis foram estudados. Foi utilizado protocolo com sequências single shot pesadas em T2 e gradiente-eco 3D pesadas em T1 pré e pós-gadolínio. Todas as imagens foram avaliadas quanto à qualidade, retrospectivamente, por dois radiologistas de forma independente. Resultados: A qualidade da imagem foi classificada como excelente para o fígado, pâncreas, rins, pulmões, órgãos pélvicos e encéfalo, e como adequada para cólon e mamas. Para as doenças vasculares as imagens foram classificadas como excelentes para aorta e seus ramos principais, veia cava inferior, veias porta e hepáticas, como boas para artérias pulmonares, e como inadequadas para coronárias. As classificações para doenças degenerativas/inflamatórias foram excelente no encéfalo, fígado e pâncreas. A concordância interobservador foi excelente. Conclusão: Um rastreamento abrangente de importantes categorias de doenças pode ser realizado utilizando imagens de alta qualidade obtidas em uma nova geração de equipamento 3T com 48 canais. Unitermos: RM de corpo inteiro; Screening; Protocolo; Resultados preliminares; 3 tesla. Since its early description, whole-body MRI has been considered a promi...

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Breath-hold 3D gradient-echo MR imaging of the lung parenchyma: Evaluation of reproducibility of image quality in normals and preliminary observations in patients with disease

Cited by 47 publications

References 15 publications

Detection of small pulmonary nodules in high-field MR at 3 T: evaluation of different pulse sequences using porcine lung explants

Detection of small pulmonary nodules in high-field MR at 3 T: evaluation of different pulse sequences using porcine lung explants

Magnetic resonance imaging of the lung with a volumetric interpolated 3D-Gradient echo sequence

Whole-body MRI: comprehensive evaluation on a 48-channel 3T MRI system in less than 40 minutes. Preliminary results

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