Breath analysis in gastrointestinal graft-versus-host disease after allogeneic hematopoietic cell transplantation

Hamilton, Betty K.; Rybicki, Lisa; Grove, David; Ferraro, Christina; Starn, Jamie; Hodgeman, Brittany; Elberson, Jamie; Winslow, Victoria; Corrigan, Donna; Gerds, Aaron T.; Hanna, Rabi; Kalaycio, Matt; Sobecks, Ronald; Majhail, Navneet S.; Dweik, Raed A.

doi:10.1182/bloodadvances.2019000345

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…In the clinical setting, breath testing is currently being used as a noninvasive diagnostic tool to identify H. pylori infection 14 and eosinophilic airway inflammation in asthma 31 . Further, emerging research has implicated diagnostic potential for a wide range of disease states, 12,19,28,32–38 and in this report, that is extended to malnutrition. However, as a retrospective chart review study, our results rely on the premise that the internal metabolic processes of malnutrition are present for a period of time surrounding the collection of the breath print.…”

Section: Discussionmentioning

confidence: 70%

The breath print represents a novel biomarker of malnutrition in pulmonary arterial hypertension: A proof of concept study

Mey

Rath

McLaughlin

et al. 2021

J Parenter Enteral Nutr

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Background:The breath print is a quantitative measurement of molecules in exhaled breath and represents a new frontier for biomarker identification. It is unknown whether this state-of-the-art, noninvasive method can detect malnutrition. We hypothesize that individuals with malnutrition will present with a distinguishable breath print. Methods: We conducted a retrospective chart review on patients with previously analyzed breath samples to identify malnutrition. Breath was analyzed by selected-ion flow-tube mass spectrometry. Registered dietitians conducted a retrospective chart review to collect malnutrition diagnoses and nutrition status indicators. Patients were categorized into one of four groups: pulmonary arterial hypertension (PAH), PAH with malnutrition (PAH-Mal), control, and control with malnutrition (Control-Mal), based on the malnutrition diagnosis present in the patient's chart. Principle component analysis was conducted to characterize the breath print. A logistic regression model with forward selection was used to detect the best breath predictor combination of malnutrition.

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Section: Discussionmentioning

confidence: 70%

The breath print represents a novel biomarker of malnutrition in pulmonary arterial hypertension: A proof of concept study

Mey

Rath

McLaughlin

et al. 2021

J Parenter Enteral Nutr

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“…They analyzed volatile organic compounds in 19 HSCT adult patients. They found that in patients developing GI GvHD, levels of five compounds, namely 2-propanol, acetaldehyde, dimethyl sulfide, isoprene, and 1-decene, were altered [ 31 ]. Some evidence suggests that GM metabolism may be involved in the production of these compounds [ 78 ].…”

Section: Polyamines and Breath Metabolitesmentioning

confidence: 99%

Microbiome-Derived Metabolites in Allogeneic Hematopoietic Stem Cell Transplantation

Masetti¹,

Zama²,

Leardini³

et al. 2021

IJMS

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The gut microbiome has emerged as a major character in the context of hematopoietic stem cell transplantation. The biology underpinning this relationship is still to be defined. Recently, mounting evidence has suggested a role for microbiome-derived metabolites in mediating crosstalk between intestinal microbial communities and the host. Some of these metabolites, such as fiber-derived short-chain fatty acids or amino acid-derived compounds, were found to have a role also in the transplant setting. New interesting data have been published on this topic, posing a new intriguing perspective on comprehension and treatment. This review provides an updated comprehensive overview of the available evidence in the field of gut microbiome-derived metabolites and hematopoietic stem cell transplantation.

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“…Various microbiota constituents are known to produce volatile metabolites, and volatile organic compounds (VOCs) generated during pathologic processes have been reported monitored in diseases such as obesity ( 81 ), hepatitis ( 82 ) and IBD ( 83 ). More recently, Hamilton et al analyzed the VOCs of patients with and without aGVHD and correctly classified 89% (17 of 19) and 90% (9 of 10) of them, respectively, showing that breath analysis is a feasible and promising noninvasive method to detect and potentially monitor aGVHD ( 84 ).…”

Section: Intestinal Microbiota In the Mechanism Of Agvhdmentioning

confidence: 99%

Interplay Between the Intestinal Microbiota and Acute Graft-Versus-Host Disease: Experimental Evidence and Clinical Significance

Hong

Wang

et al. 2021

Front. Immunol.

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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for many hematological disorders and autoimmune diseases, but acute graft-versus-host disease (aGVHD) has remained a major obstacle that limits allo-HSCT and exhibits a daunting mortality rate. The gastrointestinal system is among the most common sites affected by aGVHD. Experimental advances in the field of intestinal microbiota research enhanced our understanding - not only of the quantity and diversity of intestinal microbiota - but also their association with homeostasis of the immune system and disease pathogenesis, including that of aGVHD. Meanwhile, ever-growing clinical evidence suggest that the intestinal microbiota is dysregulated in patients who develop aGVHD and that the imbalance may affect clinical outcomes, indicating a potential predictive role for microbiota dysregulation in aGVHD severity and prognosis. The current animal and human studies investigating the intestinal microbiota in aGVHD and the understanding of the influence and management of the microbiota in the clinic are reviewed herein. Taken together, monitoring and remodeling the intestinal microecology following allo-HSCT may provide us with promising avenues for diagnosing, preventing or treating aGVHD in the clinic.

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Breath analysis in gastrointestinal graft-versus-host disease after allogeneic hematopoietic cell transplantation

Abstract: Key Points Breath analysis is a feasible novel method to detect and potentially monitor graft-versus-host disease.

Cited by 9 publications

References 24 publications

The breath print represents a novel biomarker of malnutrition in pulmonary arterial hypertension: A proof of concept study

The breath print represents a novel biomarker of malnutrition in pulmonary arterial hypertension: A proof of concept study

Microbiome-Derived Metabolites in Allogeneic Hematopoietic Stem Cell Transplantation

Interplay Between the Intestinal Microbiota and Acute Graft-Versus-Host Disease: Experimental Evidence and Clinical Significance

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