Breath ammonia detection based on tunable fiber laser photoacoustic spectroscopy

Wang, J.; Zhang, W.; Li, L.; Yu, Qingxu

doi:10.1007/s00340-011-4550-z

Cited by 49 publications

(25 citation statements)

References 20 publications

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“…These have mostly been imstrumental techniques including chemical ionisation, gas chromatography-mass spectrometry (GC-MS) (Davies et al, 1997;Van den Velde et al, 2008), selected ion flow tube mass spectrometry (SIFT-MS) (Davies et al, 1997;Enderby et al, 2009;Turner et al, 2006), laser spectroscopy and laser photoacoustic spectroscopy (LPAS) (Hibbard and Killard, 2011;Lewicki et al, 2011;Navas et al, 2012;Popa et al, 2011;Wang et al, 2011). However, most of the developed instrumental techniques are typically complex, expensive and not suitable for diagnostic application.…”

Section: Introductionmentioning

confidence: 99%

The Measurement of Ammonia in Human Breath and its Potential in Clinical Diagnostics

Brannelly

Shield

Killard

2016

Critical Reviews in Analytical Chemistry

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Section: Introductionmentioning

confidence: 99%

The Measurement of Ammonia in Human Breath and its Potential in Clinical Diagnostics

Brannelly

Shield

Killard

2016

Critical Reviews in Analytical Chemistry

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“…Gases can also be separated by gas chromatographic methods, selective trapping inside a cold trap (e.g., water), or by a specific chemical reaction. To prevent the undesired supplementary absorption of the interfering gases, especially carbon dioxide, Bratu et al used potassium hydroxide (KOH) scrubber (Merck KOH pellets) using four recipients with different volumes (13 cm 3 , 45 cm 3 , 120 cm 3 , and 213 cm 3 , respectively) in a CO 2 LPAS system before the PA cell [80]. They measured the efficiency of the KOH scrubber when it is used for multiple measurements.…”

Section: Noises and Limiting Factorsmentioning

confidence: 99%

Applications of Near Infrared Photoacoustic Spectroscopy for Analysis of Human Respiration: A Review

et al. 2020

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In this review, applications of near-infrared photoacoustic spectroscopy are presented as an opportunity to evaluate human respiration because the measurement of breath is fast, intact and simple to implement. Recently, analytical methods for measuring biomarkers in exhaled air have been extensively developed. With laser-based photoacoustic spectroscopy, volatile organic compounds can be identified with high sensitivity, at a high rate, and with very good selectivity. The literature review has shown the applicability of near-infrared photoacoustic spectroscopy to one of the problems of the real world, i.e., human health. In addition, the review will consider and explore different breath sampling methods for human respiration analysis.

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“…Patients who have renal failure even exhale 4.8 ppm ammonia. To meet the requirements of high selectivity and a detection limit lower than 50 ppb [9,10], the instrumental systems in this literature contain complex settings such as a CO 2 laser or optoelectronic signal processing modules [4,6,11,12], which require special training to use. The lack of a simple, reliable, and portable breath ammonia sensor complicates running abundant experiments in laboratories or clinics and developing point-of-care applications in follow-up steps.…”

Section: Introductionmentioning

confidence: 99%

Detecting breath ammonia for non-invasive diagnostic based on low-cost organic diode with vertical nanojunctions

Dai

Lin

et al. 2012

2012 IEEE Sensors

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We propose a novel solid-state electrical ammonia sensor based on a vertical organic diode with high-density nanopores in the top electrode. The proposed ammonia sensor has a detection limit of 20 ppb, a real-time response, sufficient selectivity, simple structure, high reproducibility, and a low production cost. In addition, we used the proposed sensor to detect the nasal breath of rats directly. After controlling the relative humidity and filtering out the CO 2 , we successfully obtained repeated real-time, reliable responses. This is the first demonstration of a solid-state sensor having reliable responses to the breath ammonia of an animal. The sensing response between normal and acute groups is significantly different (p < 0.05). These results demonstrated that the proposed ammonia sensor can detect liver that undergoes moderate hepatopathy.

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Breath ammonia detection based on tunable fiber laser photoacoustic spectroscopy

Cited by 49 publications

References 20 publications

The Measurement of Ammonia in Human Breath and its Potential in Clinical Diagnostics

The Measurement of Ammonia in Human Breath and its Potential in Clinical Diagnostics

Applications of Near Infrared Photoacoustic Spectroscopy for Analysis of Human Respiration: A Review

Detecting breath ammonia for non-invasive diagnostic based on low-cost organic diode with vertical nanojunctions

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