Breath alkanes determination in ulcerative colitis and Crohn's disease

Pelli, Maria Antonietta; Trovarelli, G.; Capodicasa, Enrico; Medio, Gianna Evelina De; Bassotti, Gabrio

doi:10.1007/bf02235186

Cited by 71 publications

(44 citation statements)

References 29 publications

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“…Breath alkanes (e.g., ethane and pentane) as markers of lipid peroxidation have been studied in IBD patients and have revealed significant lipid peroxidation in UC patients (34,35) and nonsmoking CD patients (23). 8-OHdG (a DNA oxidation product), a marker of ROS and oxidative stress, is increased in IBD patients, with no differences between UC and CD patients (24).…”

Section: Discussionmentioning

confidence: 99%

Alterations in Antioxidant Power and Levels of Epidermal Growth Factor and Nitric Oxide in Saliva of Patients with Inflammatory Bowel Diseases

et al. 2004

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Despite extensive investigation, the pathophysiology of human inflammatory bowel disease (IBD) remains incompletely understood. We examined the existence of oxidative and nitrosative stress and also alterations in epidermal growth factor (EGF) secretion in saliva of IBD patients. Saliva samples were obtained from 30 nonsmoking IBD patients including 16 Crohn's disease (CD) patients and 16 ulcerative colitis (UC) patients and 16 age- and sex-matched controls. Samples were analyzed for thiobarbituric reactive substances (TBARS) as a marker of lipid peroxidation, ferric reducing ability (antioxidant power), and EGF and nitric oxide (NO) levels. Saliva TBARS levels increased significantly (P < 0.01) in CD patients but not in UC patients. Analysis of antioxidant power revealed that saliva of CD patients has lower antioxidant power (P < 0.01) than saliva of the healthy control population. The concentration of EGF was found to be increased (P < 0.01) in saliva of CD patients in comparison to that of healthy subjects. NO levels increased in saliva of both CD and UC patients in comparison to that of healthy subjects. It is concluded that excessive NO production is present in saliva of both CD and UC patients but only saliva of CD patients is oxidatively stressed. EGF secretion is normal in UC patients, although CD patients show a significant increase in salivary EGF levels.

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Section: Discussionmentioning

confidence: 99%

Alterations in Antioxidant Power and Levels of Epidermal Growth Factor and Nitric Oxide in Saliva of Patients with Inflammatory Bowel Diseases

et al. 2004

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“…Two lines of evidence support our hypothesis: (1) lipid peroxides significantly accumulate in the gastrointestinal mucosa during development of mucosal injury or inflammation, and (2) pretreatment with superoxide dismutase (SOD, a superoxide scavenger) or a hydroxyl radical scavenger greatly attenuates these injuries, as well as inhibiting the increase in lipid peroxides. It has also been proposed that oxygen radical-mediated lipid peroxidation is involved in the development of tissue injury in Crohn's disease and ulcerative colitis [8][9][10], as well as experimental colitis in animal models [4]. Several animal models of human inflammatory bowel disease have been studied.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Novel Water-Soluble Vitamin E Derivative, 2-(.ALPHA.-D-Glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol, on Dextran Sulfate Sodium-Induced Colitis in Mice

Naito

Takagi

Matsuyama

et al. 2002

J. Clin. Biochem. Nutr.

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“…Excess lipid peroxidation may be an important pathogenetic factor in inflammatory bowel disease (IBD) such as ulcerative colitis and Crohn's disease, and breath alkanes (such as ethane, propane and pentane) determination have been shown to be elevated in IBD patients compared to control subjects; however, there was no significant difference in breath isoprene levels between patients and controls [58].…”

Section: Breath Isoprene and Its Relation To Other Disease Statesmentioning

confidence: 60%

Potential applications of breath isoprene as a biomarker in modern medicine: a concise overview

Salerno-Kennedy

Cashman

2005

Wien Klin Wochenschr

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Human breath contains hundreds of trace volatile organic compounds. These volatile substances may be generated in the body or may be absorbed as contaminants from the environment. Some of the endogenous substances are characteristic markers of pathophysiological processes and clinicians are already using breath testing of such substances as an additional non-invasive diagnostic tool for certain diseases. Isoprene, another volatile compound, is formed endogenously in humans, and while the biochemical pathways of biosynthesis and exact origins of isoprene found in human breath have not been elucidated in sufficient depth, its measurement in exhaled breath has been suggested as a non-invasive indicator with diagnostic potential. This test has not yet reached the level of routine clinical methods and is still under development. Breath isoprene levels have been reported to be altered in a number of clinical conditions; however, the physiological meaning of these changes has not been established. Various lines of supportive evidence suggest that isoprene is related to cholesterol biosynthesis. Therefore, breath isoprene measurements could potentially be used for mass screening for lipid disorders and could, at minimum, serve as an additional parameter to complement invasive tests for monitoring the efficacy of lipid-lowering therapy, pharmacological and dietary or lifestyle. As a potentially useful biomarker of mevalonate synthesis in humans, it may have non-invasive applications, not only in metabolic disorders, but possibly also in cancer screening. In the present work, we aim to give a concise overview of breath isoprene, its measurement techniques, problems concerning its physiological meaning, and potential applications as a non-invasive biomarker in modern medicine.

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Breath alkanes determination in ulcerative colitis and Crohn's disease

Cited by 71 publications

References 29 publications

Alterations in Antioxidant Power and Levels of Epidermal Growth Factor and Nitric Oxide in Saliva of Patients with Inflammatory Bowel Diseases

Alterations in Antioxidant Power and Levels of Epidermal Growth Factor and Nitric Oxide in Saliva of Patients with Inflammatory Bowel Diseases

Effect of a Novel Water-Soluble Vitamin E Derivative, 2-(.ALPHA.-D-Glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol, on Dextran Sulfate Sodium-Induced Colitis in Mice

Potential applications of breath isoprene as a biomarker in modern medicine: a concise overview

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