Breath alcohol sensor based on hydrogel-gated graphene field-effect transistor

Luo, Songjia; Wang, Rongrong; Wang, Lu; Qu, Hao; Zheng, Lei

doi:10.1016/j.bios.2022.114319

Cited by 16 publications

(9 citation statements)

References 40 publications

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“…The detection limit of this sensor is about 0.1 ppm. Zhao et al [ 25 ] developed a breath alcohol biosensor based on a hydrogel-gated graphed field-effect transistor. The carbon nanosheets (CNs) were synthesized through fast pyrolysis of chlorella.…”

Section: The Types and Principles Of Enzyme Electrode Electrochemical...mentioning

confidence: 99%

Design and Construction of Enzyme-Based Electrochemical Gas Sensors

Zhang,

Chen,

Xing

et al. 2023

Molecules

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The demand for the ubiquitous detection of gases in complex environments is driving the design of highly specific gas sensors for the development of the Internet of Things, such as indoor air quality testing, human exhaled disease detection, monitoring gas emissions, etc. The interaction between analytes and bioreceptors can described as a “lock-and-key”, in which the specific catalysis between enzymes and gas molecules provides a new paradigm for the construction of high-sensitivity and -specificity gas sensors. The electrochemical method has been widely used in gas detection and in the design and construction of enzyme-based electrochemical gas sensors, in which the specificity of an enzyme to a substrate is determined by a specific functional domain or recognition interface, which is the active site of the enzyme that can specifically catalyze the gas reaction, and the electrode–solution interface, where the chemical reaction occurs, respectively. As a result, the engineering design of the enzyme electrode interface is crucial in the process of designing and constructing enzyme-based electrochemical gas sensors. In this review, we summarize the design of enzyme-based electrochemical gas sensors. We particularly focus on the main concepts of enzyme electrodes and the selection and design of materials, as well as the immobilization of enzymes and construction methods. Furthermore, we discuss the fundamental factors that affect electron transfer at the enzyme electrode interface for electrochemical gas sensors and the challenges and opportunities related to the design and construction of these sensors.

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Section: The Types and Principles Of Enzyme Electrode Electrochemical...mentioning

confidence: 99%

Design and Construction of Enzyme-Based Electrochemical Gas Sensors

Zhang,

Chen,

Xing

et al. 2023

Molecules

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“…The traditional detection method of drunk driving is that the traffic police conduct spot checks within a certain period of time through an alcohol detector, which cannot achieve large-scale monitoring. The onboard ethanol sensor is expected to solve the problems of real-time monitoring and rapid initial screening of drunk driving . The average concentration of ethanol in the breath of healthy individuals is around 100 ppb; excess of ethanol has been related to renal failure, cardiopulmonary diseases, and protein intoxication and abuse .…”

Section: Introductionmentioning

confidence: 99%

“…The onboard ethanol sensor is expected to solve the problems of real-time monitoring and rapid initial screening of drunk driving. 5 The average concentration of ethanol in the breath of healthy individuals is around 100 ppb; excess of ethanol has been related to renal failure, cardiopulmonary diseases, and protein intoxication and abuse. 6 The maximum allowable ethanol concentration for Italy is 130 ppm (0.05% in blood) and 208 ppm in the US (0.08% in blood) for drivers.…”

Section: ■ Introductionmentioning

confidence: 99%

Hollow-Out Fe₂O₃-Loaded NiO Heterojunction Nanorods Enable Real-Time Exhaled Ethanol Monitoring under High Humidity

Zhou

et al. 2023

ACS Appl. Mater. Interfaces

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The analysis of exhaled breath has opened up new exciting avenues in medical diagnostics, sleep monitoring, and drunk driving detection. Nevertheless, the detection accuracy is greatly affected due to high humidity in the exhaled breath. Here, we propose a regulation method to solve the problem of humidity adaptability in the ethanol-monitoring process by building a heterojunction and hollow-out nanostructure. Therefore, large specific surface area hollow-out Fe2O3-loaded NiO heterojunction nanorods assembled by porous ultrathin nanosheets were prepared by a well-tailored interface reaction. The excellent response (51.2 toward 10 ppm ethanol at 80% relative humidity) and selectivity to ethanol under high relative humidity with a lower operating temperature (150 °C) were obtained, and the detection limit was as low as 0.5 ppb with excellent long-term stability. The superior gas-sensing performance was attributed to the high surface activity of the heterojunction and hollow-out nanostructure. More importantly, GC–MS, diffuse reflectance Fourier transform infrared spectroscopy, and DFT were utilized to analyze the mechanisms of heterojunction sensitization, ethanol-sensing reaction, and high-humidity adaptability. Our integrated low-power MEMS Internet of Things (IoT) system based on Fe2O3@NiO successfully demonstrates the functional verification of ethanol detection in human exhalation, and the integrated voice alarm and IoT positioning functions are expected to solve the problem of real-time monitoring and rapid initial screening of drunk driving. Overall, this novel method plays a vital role in areas such as control of material morphology and composition, breath analysis, gas-sensing mechanism research, and artificial olfaction.

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“…Graphene is a two-dimensional (2D) carbonaceous nanomaterial with sp 2 -hybridized carbon atoms arranged in a honeycomb lattice and has attracted tremendous attention as a result of its high intrinsic carrier mobility (200 000 cm 2 V –1 s –1 ), excellent thermal conductivity (5000 W m –1 K –1 ), high optical transmittance (97.7%), large specific surface area (SSA, 2630 cm 2 g –1 ), superior mechanical strength, etc. − Considerable effort has been devoted to the assembly of graphene-based macroforms to fully utilize the above-mentioned remarkable properties of individual sheets in macroscopic scale. Thus far, a diversity of graphene-based macroforms, including fibers, , membranes, , and hydrogels and aerogels, , have been fabricated, and their potential applications have been extensively explored. , Among these macroforms, graphene-based aerogels characterized by low density, large SSA, high porosity, and low thermal conductivity − show promising applications in the fields of energy storage, sensors, catalysis, thermal insulators, etc.…”

Section: Introductionmentioning

confidence: 99%

“…1−3 Considerable effort has been devoted to the assembly of graphene-based macroforms to fully utilize the abovementioned remarkable properties of individual sheets in macroscopic scale. Thus far, a diversity of graphene-based macroforms, including fibers, 4,5 membranes, 6,7 and hydrogels and aerogels, 8,9 have been fabricated, and their potential applications have been extensively explored. 10,11 Among these macroforms, graphene-based aerogels characterized by low density, large SSA, high porosity, and low thermal conductivity 12−14 show promising applications in the fields of energy storage, sensors, catalysis, thermal insulators, etc.…”

Section: Introductionmentioning

confidence: 99%

Hierarchically Porous Graphene Aerogels with Abundant Oxygenated Groups for High-Energy-Density Surpercapacitors

et al. 2022

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A hierarchically porous graphene aerogel (HP-GA) with abundant oxygenated groups and hand-tearing bread-like macromorphology is achieved by a sacrificial MnO 2 template approach. Oxygenated groups on graphene sheets improve the wettability of HP-GA to an aqueous electrolyte and contribute to pseudocapacitance. The chlorine (Cl 2 ) gas as a result of the reaction of MnO 2 and HCl is responsible for the formation of the hierarchically porous microstructure and hand-tearing bread-like macromorphology, ensuring a large electrolyte accessible surface area within the electrodes. When used as the active electrode material in supercapacitors, HP-GA exhibits a large specific capacitance of 284 F g −1 at 1 A g −1 and ultrahigh energy density of 10 Wh kg −1 at 250 W kg −1 in an aqueous electrolyte. This work provides a versitile, simple, and easy to control way to alter the microstructure and macromorphology of graphene-based areogels that have promising applications in many areas, including adsorption, energy storage, heat insulation, acoustical insulation, and intelligent sensing system.

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Breath alcohol sensor based on hydrogel-gated graphene field-effect transistor

Cited by 16 publications

References 40 publications

Design and Construction of Enzyme-Based Electrochemical Gas Sensors

Design and Construction of Enzyme-Based Electrochemical Gas Sensors

Hollow-Out Fe₂O₃-Loaded NiO Heterojunction Nanorods Enable Real-Time Exhaled Ethanol Monitoring under High Humidity

Hierarchically Porous Graphene Aerogels with Abundant Oxygenated Groups for High-Energy-Density Surpercapacitors

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Breath alcohol sensor based on hydrogel-gated graphene field-effect transistor

Cited by 16 publications

References 40 publications

Design and Construction of Enzyme-Based Electrochemical Gas Sensors

Design and Construction of Enzyme-Based Electrochemical Gas Sensors

Hollow-Out Fe2O3-Loaded NiO Heterojunction Nanorods Enable Real-Time Exhaled Ethanol Monitoring under High Humidity

Hierarchically Porous Graphene Aerogels with Abundant Oxygenated Groups for High-Energy-Density Surpercapacitors

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Hollow-Out Fe₂O₃-Loaded NiO Heterojunction Nanorods Enable Real-Time Exhaled Ethanol Monitoring under High Humidity