Breastfeeding May Protect from Developing Attention-Deficit/Hyperactivity Disorder

Mimouni-Bloch, Aviva; Kachevanskaya, Anna; Mimouni, Francis; Shuper, Avinoam; Raveh, Eyal; Linder, Nehama

doi:10.1089/bfm.2012.0145

Cited by 84 publications

(50 citation statements)

References 19 publications

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“…118,119 A retrospective analysis of children 6-12 years of age who were diagnosed with ADHD relative to those without this disorder indicated breastfeeding may protect male and female offspring from developing this disorder. 120 Although such studies provide hints that breastfeeding may combat against developing complex neurological diseases, the findings may also be due to other confounding factors. These include genetics, environmental background, nutritional, overall health, socioeconomic, nutritional and metabolic status of both parents to list a few examples.…”

Section: Offspring Cancermentioning

confidence: 99%

Homage to the ‘H’ in developmental origins of health and disease

Rosenfeld

2016

J Dev Orig Health Dis

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Abundant evidence exists linking maternal and paternal environments from pericopconception through the postnatal period to later risk to offspring diseases. This concept was first articulated by the late Sir David Barker and as such coined the Barker Hypothesis. The term was then mutated to Fetal Origins of Adult Disease and finally broadened to developmental origins of adult health and disease (DOHaD) in recognition that the perinatal environment can shape both health and disease in resulting offspring. Developmental exposure to various factors, including stress, obesity, caloric-rich diets and environmental chemicals can lead to detrimental offspring health outcomes. However, less attention has been paid to date on measures that parents can take to promote the long-term health of their offspring. In essence, have we neglected to consider the ‘H’ in DOHaD? It is the ‘H’ component that should be of primary concern to expecting mothers and fathers and those seeking to have children. While it may not be possible to eliminate exposure to all pernicious factors, prevention/remediation strategies may tip the scale to health rather than disease. By understanding disruptive DOHaD mechanisms, it may also illuminate behavioral modifications that parents can adapt before fertilization and throughout the neonatal period to promote the lifelong health of their male and female offspring. Three possibilities will be explored in the current review: parental exercise, probiotic supplementation and breastfeeding in the case of mothers. The ‘H’ paradigm should be the focus going forward as a healthy start can indeed last a lifetime.

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Section: Offspring Cancermentioning

confidence: 99%

Homage to the ‘H’ in developmental origins of health and disease

Rosenfeld

2016

J Dev Orig Health Dis

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“…20 Kadziela-Olech and Piotrowska-Jastrzebska, 2005;Mimouni-Bloch et al, 2013). On the other hand, children also exposed to PCBs postnatally via breastfeeding may show more severe deficits later in life in comparison to no-breastfed children (e.g., Verner et al, 2015a).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Assessing new dimensions of attentional functions in children prenatally exposed to environmental contaminants using an adapted Posner paradigm

Ethier

Muckle

Ayotte

et al. 2015

Neurotoxicology and Teratology

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Chronic exposure to methylmercury (MeHg), lead (Pb) and polychlorinated biphenyls (PCBs) has been associated with a range of attention deficits in children, but it is not known whether selective spatial attention is also altered. We modified the classic Posner paradigm, which assesses visuospatial attention, to also assess vigilance and impulsivity. This paradigm is based on the well-documented findings that a target will be detected more quickly if a visual cue indicates beforehand where it will appear, and more slowly if the cue indicates a false spatial location. In our task, visual distractors were introduced, in addition to the classic Posner trials, to assess impulsivity, and a central smiley face, whose eye-movement cued the location of the targets, to measure spatial attention. This task was administered to 27 school-age Inuit children (mean age = 11.2 years) from Nunavik (Arctic Quebec, Canada), in which pre- and postnatal exposures to environmental contaminants had been documented from birth. After controlling for the impact of confounding variables, multivariable regressions revealed that prenatal exposures to PCBs and Pb were significantly associated with greater inattention and impulsivity, respectively, while current exposure to Pb was significantly associated with longer reaction times. Although a significant correlation was observed between cord blood PCB concentration and decreased visuospatial performance, no significant association was found after adjustment for confounders. No effect was found for Hg exposures. These results suggest that our adapted Posner paradigm is sensitive in detecting a range of attention deficits in children exposed to environmental contaminants; implications for future studies are discussed.

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“…The literature to date has revealed that breastfeeding exposure and duration can have important implications for the neuropsychological and behavioral well-being of offspring [11,16,33,36,51,53]. Despite the increased attention given to the contribution of breastfeeding experiences during infancy to the subsequent functioning of offspring, most research focuses on child outcomes, with few studies exploring the effects of breastfeeding exposure and duration on neuropsychological and mental health outcomes during later life Fig.…”

Section: Discussionmentioning

confidence: 99%

“…A more recent line of research has indicated that breastfeeding can also protect against abnormal development of offspring across cognitive, psychological, social, and behavioral domains [11,16,33,36,51,53]. For example, research suggests that children who were breastfed for longer time periods tend to evince greater language ability [23], motor ability [23], and overall intelligence [52] relative to children who were never breastfed or who were breastfed for shorter durations.…”

Section: Introductionmentioning

confidence: 99%

“…For example, research suggests that children who were breastfed for longer time periods tend to evince greater language ability [23], motor ability [23], and overall intelligence [52] relative to children who were never breastfed or who were breastfed for shorter durations. A shorter duration of breastfeeding also seems to increase the risk of several psychological and behavioral problems, including ADHD symptoms [51], internalizing and externalizing problems [33,53] and schizophrenia [64]. A number of studies have shown that the association between breastfeeding and neuropsychological outcomes is at least partially driven by the nutritional content of breast milk, particularly through the supplement of long-chain polyunsaturated fatty acids such as docosahexaenoic acid [31,46].…”

Section: Introductionmentioning

confidence: 99%

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The Association Between Breastfeeding Exposure and Duration, Neuropsychological Deficits, and Psychopathic Personality Traits in Offspring: The Moderating Role of 5HTTLPR

Jackson

Beaver

2015

Psychiatr Q

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A wealth of research has revealed that a shorter duration of breastfeeding during infancy can increase the risk of various maladaptive traits, including neuropsychological deficits. Despite the number of studies that have been conducted on the topic, few studies have explored whether the effects of breastfeeding on neuropsychological functioning and personality features persist into adulthood. Furthermore, very little research to date has examined whether this relationship is moderated by specific indicators of genetic risk. The current study examines the direct and interactive effects of breastfeeding experiences and the serotonin transporter polymorphism (5HTTLPR) on neuropsychological deficits and psychopathic personality traits. Using data from the National Longitudinal study of Adolescent Health, we find that no exposure to breastfeeding and a shorter duration of breastfeeding significantly increase the risk of exhibiting neuropsychological deficits during adolescence and early adulthood as well as psychopathic personality traits during adulthood. The results also reveal a number of gene × environment interactions between 5HTTLPR, breastfeeding exposure and breastfeeding duration in the prediction of neuropsychological deficits, but not in the prediction of psychopathic personality traits.

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Breastfeeding May Protect from Developing Attention-Deficit/Hyperactivity Disorder

Abstract: Children with ADHD were less likely to breastfeed at 3 months and 6 months of age than children in the two control groups. We speculate that breastfeeding may have a protective effect from developing ADHD later in childhood.

Cited by 84 publications

References 19 publications

Homage to the ‘H’ in developmental origins of health and disease

Homage to the ‘H’ in developmental origins of health and disease

Assessing new dimensions of attentional functions in children prenatally exposed to environmental contaminants using an adapted Posner paradigm

The Association Between Breastfeeding Exposure and Duration, Neuropsychological Deficits, and Psychopathic Personality Traits in Offspring: The Moderating Role of 5HTTLPR

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