Breastfeeding, Long-Chain Polyunsaturated Fatty Acids in Colostrum, and Infant Mental Development

Guxens, Mònica; Mendez, Michelle A.; Moltó-Puigmartí, Carolina; Júlvez, Jordi; García-Esteban, Raquel; Forns, Joan; Ferrer, Muriel; Vrijheid, Martine; López-Sabater, M. Carmen; Sunyer, Jordi

doi:10.1542/peds.2010-1633

Cited by 94 publications

(88 citation statements)

References 51 publications

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“…The results of the present study are in agreement with the few previous observational studies that investigated LCPUFA Articles levels in colostrum, transitional or mature breast milk, in relation with later child cognition, and that found no strong evidence for a beneficial role of LCPUFA, in order to explain the relationship between breastfeeding and cognition (12)(13)(14)(15)(16). Most of the literature on this topic comes from randomized controlled trials.…”

Section: Discussionsupporting

confidence: 92%

“…Such association was previously highlighted among 51 preterm infants of 6 mo of age (14). In other studies, authors reported negative associations between cognition and PUFA ratios, especially LA/ALA, AA/ DHA, and total n-6/n-3 (12,14,15). In our study, we observed a negative and significant association between total n-6/n-3 PUFA ratio and the ASQ-3 score, but this was not observed with Motor-2 and CDI-2.…”

Section: Discussionsupporting

confidence: 54%

“…The largest one used the data from the Spanish INMA mother-child cohort and included 504 infants aged 14 mo. The authors showed that mental development score, as measured with the Bayley's Scales on Infant Development, was five points higher among infants exposed to both the higher intensity of breastfeeding and colostrum with low n-6/n-3 ratio, than among infants less exposed to breastfeeding, as well as those exposed to colostrum with higher n-6/n-3 ratio (12). The follow-up of the participants to 4 y of age, did not confirm this finding: the colostrum content in n-3 PUFA was not associated with cognitive development, as measured with the McCarthy Scales of Children's Abilities (13).…”

mentioning

confidence: 99%

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The association between linoleic acid levels in colostrum and child cognition at 2 and 3 y in the EDEN cohort

et al. 2015

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Background: Breastfeeding has been associated with improved cognitive development. This may be explained by polyunsaturated fatty acid (PUFA) content of breast milk, especially long-chain (LC) PUFA that are needed for postnatal brain growth. Methods: Using data from the French EDEN cohort, we aimed to study whether the PUFA content of colostrum may explain observed associations between breastfeeding duration and cognitive scores at 2 and 3 y. A total of 709 breastfed children with available data on PUFA composition of milk were assessed using parent-reported questionnaires for motor and language at 2 y of age, or global cognition at 3 y. Multiple linear regressions were used to examine associations between PUFA levels and child cognitive scores, after controlling for many confounders. results: We found no association between LCPUFA levels in colostrum and child development. However, levels of linoleic acid (LA) were negatively associated with motor and cognitive scores, independently of breastfeeding duration. Children breastfed with the highest levels of LA tended to score closer to the never breastfed children than children breastfed with the lowest levels of LA. conclusion: Our findings suggest that too high levels of LA in colostrum are associated with poorer child development at 2 and 3 y.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 54%

mentioning

confidence: 99%

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The association between linoleic acid levels in colostrum and child cognition at 2 and 3 y in the EDEN cohort

et al. 2015

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“…137 LC-PUFA in colostrum may boost mental development in children who are breastfed for a prolonged duration. 138 Maternal hormones within the milk may also affect later offspring neurobehavioral functions. For instance, greater amount of cortisol in human milk appears to impact infant temperament, as evidenced by a positive association with negative affectivity or emotions in girls.…”

Section: Offspring Cancermentioning

confidence: 99%

Homage to the ‘H’ in developmental origins of health and disease

Rosenfeld

2016

J Dev Orig Health Dis

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Abundant evidence exists linking maternal and paternal environments from pericopconception through the postnatal period to later risk to offspring diseases. This concept was first articulated by the late Sir David Barker and as such coined the Barker Hypothesis. The term was then mutated to Fetal Origins of Adult Disease and finally broadened to developmental origins of adult health and disease (DOHaD) in recognition that the perinatal environment can shape both health and disease in resulting offspring. Developmental exposure to various factors, including stress, obesity, caloric-rich diets and environmental chemicals can lead to detrimental offspring health outcomes. However, less attention has been paid to date on measures that parents can take to promote the long-term health of their offspring. In essence, have we neglected to consider the ‘H’ in DOHaD? It is the ‘H’ component that should be of primary concern to expecting mothers and fathers and those seeking to have children. While it may not be possible to eliminate exposure to all pernicious factors, prevention/remediation strategies may tip the scale to health rather than disease. By understanding disruptive DOHaD mechanisms, it may also illuminate behavioral modifications that parents can adapt before fertilization and throughout the neonatal period to promote the lifelong health of their male and female offspring. Three possibilities will be explored in the current review: parental exercise, probiotic supplementation and breastfeeding in the case of mothers. The ‘H’ paradigm should be the focus going forward as a healthy start can indeed last a lifetime.

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“…Some of the explanations for these associations may be the amount of essential polyunsaturated fatty acids (PUFA) in breast milk 36 , as well as the warning level that mothers might have in order to detect any psychomotor problem of their children and a greater orentation and stimulous to the development of the infant 37 .…”

Section: Breastfeeding and Psychomotor Developmentmentioning

confidence: 99%

Lactancia materna, desarrollo motor y obesidad, ¿Existe asociación causal?

2017

Rev. chil. pediatr.

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Childhood obesity is the main nutritional and public health problem in Chile, being the principal causes, the increase in energy dense foods and the decline of physical activity. Interventions to prevent obesity at infancy are focused mainly in improving quality and quantity of dietary intake, without taking into account physical activity, which is expressed under two years of age, mainly by motor development. Some studies have proven that motor development at early age, may influence the ability to perform physical activity. Thus, infants scoring a lower motor development may have a greater risk of becoming obese. It isn't know if childhood obesity causes lower motor development (given that children may have greater difficulty to move), or on the contrary, it is the lower ability to move, which increases the obesity risk. The objective of this manuscriptis analize the evidence regards the relation between breastfeeding, motor development and obesity in the childhood.To be able to understand this asocation and casual mecanism, it is important to develop stategys focused in early infancy to promote breastfeeding, healthy eating and early stimulation, starting in pediatric office. 452ClINICal OveRvIew Breastfeeding, gross motor development and obesity -G. weisstaub N et al

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Breastfeeding, Long-Chain Polyunsaturated Fatty Acids in Colostrum, and Infant Mental Development

Cited by 94 publications

References 51 publications

The association between linoleic acid levels in colostrum and child cognition at 2 and 3 y in the EDEN cohort

The association between linoleic acid levels in colostrum and child cognition at 2 and 3 y in the EDEN cohort

Homage to the ‘H’ in developmental origins of health and disease

Lactancia materna, desarrollo motor y obesidad, ¿Existe asociación causal?

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