Breastfeeding and Breast Cancer Risk: An Evaluation Based on a Systematic Review of Epidemiologic Evidence Among the Japanese Population

Nagata, Chisato; Mizoue, Tetsuya; Tanaka, Keitaro; Tsuji, Ichiro; Tamakoshi, Akiko; Wakai, Kenji; Matsuo, Keitaro; Ito, Hidemi; Sasazuki, Shizuka; Inoue, Manami; Tsugane, Shoichiro

doi:10.1093/jjco/hyr182

Cited by 20 publications

(17 citation statements)

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“…The association between breastfeeding and BC remains unclear in western populations [16,17].We observed no protective association between total duration of breastfeeding and BC risk in either rural or urban women in our population. A similar observation of no association was reported in a recent systematic review of Japanese studies [18]. Breastfeeding is a universal practice in India, with a very high prevalence of 96 % in both urban and rural areas [19].…”

Section: Discussionsupporting

confidence: 76%

Understanding rural–urban differences in risk factors for breast cancer in an Indian population

Nagrani

Mhatre

Boffetta

et al. 2015

Cancer Causes Control

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Section: Discussionsupporting

confidence: 76%

Understanding rural–urban differences in risk factors for breast cancer in an Indian population

Nagrani

Mhatre

Boffetta

et al. 2015

Cancer Causes Control

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“…Differences in the timing and measurement of breast density between these diverse studies are the most likely explanation for their disparate associations, though this could also be due to basic differences in the study populations. Although breast-feeding has been thought to produce an overall protective effect against breast cancer (e.g., [37]), many studies find no association (e.g., [22]) and recent systematic reviews of the topic fail to support an association (e.g., [38, 39]). More research is needed in the area of breast-feeding and breast health to better elucidate whether a protective effect exists, and if so, when and how breast-feeding might affect breast density.…”

Section: Discussionmentioning

confidence: 99%

First pregnancy events and future breast density: modification by age at first pregnancy and specific VEGF and IGF1R gene variants

Prebil

Ereman

Powell

et al. 2014

Cancer Causes Control

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Purpose Pregnancy characteristics have been associated with breast cancer risk, but information is limited on their relationship with breast density. Our objective was to examine the relationship between first pregnancy characteristics and later life breast density, and whether the association is modified by genotype.Methods The Marin Women’s Study was initiated to examine breast cancer in a high-incidence mammography population (Marin County, CA). Reproductive characteristics and pregnancy information including pregnancy-induced hypertension (PIH) were self-reported at the time of mammography. Forty-seven candidate single nucleotide polymorphisms were obtained from saliva samples; seven were assessed in relation to PIH and percent fibroglandular volume (%FGV). Breast density assessed as %FGV was measured on full-field digital mammograms by the San Francisco Mammography Registry.ResultsA multivariable regression model including 2,440 parous women showed that PIH during first pregnancy was associated with a statistically significant decrease in %FGV (b = −0.31, 95 % CI −0.52, −0.11), while each month of breast-feeding after first birth was associated with a statistically significant increase in %FGV (b = 0.01, 95 % CI 0.003, 0.02). PIH and breast-feeding associations with %FGV were modified by age at first birth. In a subsample of 1,240 women, there was evidence of modification in the association between PIH and %FGV by specific vascular endothelial growth factor (VEGF) (rs3025039) and insulin growth factor receptor-1 (IGFR1) (rs2016347) gene variants.ConclusionThese findings suggest that first pregnancy characteristics may exert an influence on extent of breast density later in life and that this influence may vary depending on inherited IGFR1 and VEGF genotypes.Electronic supplementary materialThe online version of this article (doi:10.1007/s10552-014-0386-2) contains supplementary material, which is available to authorized users.

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“…A report from Japan also confirmed that breastfediing had decreased the risk of breast cancer by a large extent (18). In addition to many health advantages for babies, breastfeeding also prevents many severe diseases such as breast cancer in mothers (19).…”

Section: Introductionmentioning

confidence: 93%

“…The number of children who had given birth, continuous breastfeeding and duration of breastfeeding were also studied as to whether they had had any possible effect on breast cancer (13)(14)(15)(16)(17)(18). A decreased risk of breast cancer by 38% in women who had been continously breastfeeding in addition to a remarkable decrease with longer lasting lactation were reported by Yoo et al (14).…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of a Special Clinical Series: Breast Cancer in Breastfeeding Mothers and Delay in Diagnosis

Kizilkaya¹,

Kocakuşak²,

Alkurt³

et al. 2014

J Breasth Health

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Objective:We aimed to investigate lactating mothers who were admitted to our breast polyclinic and diagnosed as breast cancer.Materials and Methods: Ten lactating mothers with breast cancer from 112 breast cancer patients among 2380 patients admitted to our breast diseases policlinic were evaluated retrospectively.Results: Ten of 112 breast cancer patients were lactating women. The mean age of those patients was 33.2 (28-39) years. The mean lactating period was 8.4 months (5-12 months). The average number of children of the patients was two (1-3 child per patient). The results of the tru-cut biopsis were invasive ductal carcinoma in all patients. All patients were triple negative in regard to receptors, except for one, in whom oestrogen and c-erbB2 receptors were positive, whereas the progesterone receptor was negative. Two of the patients were in follow up due to a galactocele for three months. Four patients had multicentric disease in the same breast. Bone metastasis in three, left supraclavicular lymph node metastasis in two and locally advanced breast carcinoma in one patient were detected. Three patients underwent modified radical mastectomy, one patient was given neoadjuvant treatment, however the remaining six patients were given adjuvant oncological treatment. Conclusion:The diagnosis of breast carcinoma in lactating mother is delayed and therefore, prognosis as well as mortality are negatively influenced.Amaç: Emziren annede meme kanseri olasılığını göz ardı etmeden meme polikliniğimize başvuran ve meme kanseri tanısı alan emziren annelerimizi inceleyerek sunmayı amaçladık.Yöntem ve Gereçler: Son bir yılda meme polikliniğimize başvuran 2380 hastadan tanı almış 112 meme kanseri vakasından çocuğunu emzirmekte olan 10 anne retrospektif olarak incelendi. Bulgular: Tanı almış 112 meme kanseri hastasından 10'u çocuğunu halen emzirmekte olan annelerdi. Bu hastaların ortalama yaşı 33,2 (28-39) yıl idi. Ortalama 8,4 aydır (5-12 ay) emziriyorlardı. Bu hastaların ortalama iki (1-3) çocukları vardı. Hepsinin tru-cut biyopsi sonuçları invaziv duktal kanser olarak gelmişti. Sadece bir hastada estrojen reseptör (+), progesteron (-) ve c-erbB2 (+++) idi. Diğerlerinde tüm reseptörler negatif idi(triple negatif ). Hastalardan ikisi galaktosel tanısı ile üç aydır takip edilmekte idi. Aynı memede birden fazla tümör odağı olan dört hasta mevcuttu. Hastalardan üçünde kemik metastazı, ikisinde sol supraklaviküler lenf nodu metastazı, üçünde aksiller lenf nodu metastazı ve birinde lokal ileri tümör mevcuttu. Üç hastaya modifiye radikal mastektomi uygulandı. Bir hasta neoadjuvan onkolojik tedaviye verildi ve yedi hastaya adjuvan onkolojik tedavi önerildi.Sonuç: Emziren annede meme kanseri teşhisi oldukça geç olmakta ve bu da sağkalımı ve mortaliteyi olumsuz yönde etkilemektedir.

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Breastfeeding and Breast Cancer Risk: An Evaluation Based on a Systematic Review of Epidemiologic Evidence Among the Japanese Population

Cited by 20 publications

References 20 publications

Understanding rural–urban differences in risk factors for breast cancer in an Indian population

Understanding rural–urban differences in risk factors for breast cancer in an Indian population

First pregnancy events and future breast density: modification by age at first pregnancy and specific VEGF and IGF1R gene variants

The Evaluation of a Special Clinical Series: Breast Cancer in Breastfeeding Mothers and Delay in Diagnosis

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