Breast tumour resembling tall cell variant of papillary thyroid carcinoma: case presentation (in a patient with Lynch syndrome)

Gai, Luis; Done, Susan J.; Cook, Donald L.; Denic, Nash; Erivwo, Polycarp; Voisey, Kim; Kao, Kenneth R.

doi:10.1136/jclinpath-2018-205337

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…As the incidence of TCCRP is low, it is difficult to conduct a valuable retrospective analysis of the disease from independent case reports or small-scale cohort studies. However, we comprehensively reviewed relevant articles (15 in total) published from 2003 to date, and extracted key information including demographic, clinicopathologic, and immunohistochemical data, along with hotspot gene sequencing results (Tables S1,S2), to detect meaningful patterns by expanding the sample size (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). After eliminating the repeated cases from among the abovementioned studies, a total of 74 cases (including this present case) remained.…”

Section: Discussionmentioning

confidence: 99%

Tall cell carcinoma of the breast with reverse polarity: case report with gene sequencing and literature review

Zhang

Wang

et al. 2021

Gland Surg

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Tall cell carcinoma of the breast with reverse polarity (TCCRP), described firstly and also known as tall cell variant of papillary breast carcinoma (TCVPBC), is a rare type of breast cancer that mimics papillary thyroid carcinoma (PTC) histopathologically. As the incidence of this type of tumor is very low, awareness of it is crucial to ensuring that unnecessary clinical investigations are avoided. The present study examined a 45-year-old woman in China who was diagnosed with TCCRP. This paper outlines her demographic and clinicopathologic data, and her follow-up and immunohistochemical examination results.Furthermore, this study used the next-generation sequencing (NGS) technique to identify concurrent isocitrate dehydrogenase 2 (IDH2) and phosphatidylinositol 3-kinase catalytic alpha (PIK3CA) hotspot mutations. Notably, the novel results of the study showed that the IDH2 R120 (rather than the IDH2 R172) mutation may also be present in this disease. Additionally, a comprehensive literature review was conducted to elucidate some of the significant clinical and pathological features of this type of disease. This information may provide important insights that can be used in diagnosis and treatment. It is essential both for physicians and pathologists to recognize the existence of TCCRP, with its own specific clinical and pathological characteristics. Further research using molecular biology techniques should be conducted in the future to characterize this unique entity.

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Section: Discussionmentioning

confidence: 99%

Tall cell carcinoma of the breast with reverse polarity: case report with gene sequencing and literature review

Zhang

Wang

et al. 2021

Gland Surg

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“…Bhargava et al employed FISH detection of the ETV-6 gene in one case of TCCRP and secretory carcinoma (yielding negative results) (10). A Solid mammary head, columnar cells, and reversal of nuclear polarity support the diagnosis of TRRCP while S-100 positivity is observed in TCCRP (10,17). Cystic hypersecretory lesions/tumour: This group of diseases needs to be distinguished from TCCRP because of the prominent follicular changes in the thyroid.…”

Section: Discussionmentioning

confidence: 99%

Case report: Tall cell carcinoma with reversed polarity of the breast: an additional case and review of the literature

Lei,

Wang,

Wang

et al. 2024

Front. Oncol.

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ObjectiveThe aim of this report was to comprehensively investigate the clinicopathological features, histological characteristics, and differential diagnosis of tall cell carcinoma with reversed polarity of the breast (TCCRP) to enhance the understanding of this tumour for precise therapeutic interventions.MethodsThe clinicopathological characteristics and differential diagnosis of a patient with TCCRP were retrospectively analysed, and a systematic literature review was extracted from relevant published studies on PubMed.ResultsAll patients included in the study were female, with a median age of 51 years. Microscopically, the tumour cells exhibited a solid papillary growth pattern with tall columnar morphology and reversed nuclear polarity. Immunohistochemistry revealed that the tumours were triple-negative breast cancer (negative for ER, PR, and HER-2), with a low Ki-67 proliferation index. Different degrees of expression were observed for CK7, Calretinin, and S-100 markers; however, CK5/6 showed high expression levels.ConclusionsTCCRP is an uncommon invasive carcinoma subtype found in the breast. Its histological morphology resembles that of tall cell subtype papillary thyroid carcinoma. Accurate diagnosis requires the integration of histomorphological assessment along with immunohistochemistry and molecular genetics analysis.

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“…TCCRP has been considered to be an invasive tumor with only a few cases reported as carcinoma in situ (still controversial due to improper IHC tests) [1,2,[4][5][6][7][8][9][10][11][12][13][14][15]. In addition, this tumor is underpinned by recurrent nding of IDH2 (hot spot mutations in residue 172) mutations accompanied with genetic alterations in the PI3K signaling pathway, especially PIK3CA [1,16,17].…”

Section: Discussionmentioning

confidence: 99%

A New Subtype of Papillary Ductal Carcinoma in Situ with Tall Cell and Reversed Polarity Morphology: A Rare Case

Zhong,

Chang,

Wang

et al. 2023

Preprint

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Papillary ductal carcinoma in situ (DCIS) is a subtype of DCIS characterized by the neoplastic proliferation of epithelial cells with a papillary structure and confined to the mammary ductal-lobular system. Tall cell carcinoma with reversed polarity (TCCRP) is a rare subtype of invasive breast carcinoma with low malignant potential, which has recently been recognized as a separate entity in the 2019 WHO Classification of breast tumors. Here, we describe the case of a 54-year-old woman with a finding of growing nodular lesion through breast ultrasonographic screenings, whose morphological features, immunohistochemical results, and molecular genetic studies suggest overlapping features of DCIS and TCCRP. Therefore, we hypothesized that it might be a new DCIS subtype with tall cells and reversed polarity of the mammary gland.

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Breast tumour resembling tall cell variant of papillary thyroid carcinoma: case presentation (in a patient with Lynch syndrome)

Cited by 7 publications

References 8 publications

Tall cell carcinoma of the breast with reverse polarity: case report with gene sequencing and literature review

Tall cell carcinoma of the breast with reverse polarity: case report with gene sequencing and literature review

Case report: Tall cell carcinoma with reversed polarity of the breast: an additional case and review of the literature

A New Subtype of Papillary Ductal Carcinoma in Situ with Tall Cell and Reversed Polarity Morphology: A Rare Case

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