Breast Trauma and Triple-Negative Hemorrhagic Cystic Carcinoma: Management and Treatment

Cotesta, Maria; Buonomo, Oreste Claudio; Majo, Adriano De; Vanni, Gianluca; Materazzo, Marco; Santori, Francesca; Granai, Alessandra Vittoria; Pistolese, Chiara Adriana; Servadei, Francesca; Finocchiaro, Susanna; Giacobbi, Erica; Anemona, Lucia; Pellicciaro, Marco

doi:10.12659/ajcr.925014

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…However, despite the expected development of a hematoma after chest wall trauma, we became concerned for malignancy with the persistence of symptoms after initial drainage despite no previous signs or history indicative of breast cancer. Breast carcinoma presenting as a post-traumatic hemorrhagic cyst is rare, but possible [7]. There are only a few reports of EPC presenting after trauma, and much less so specifying a trauma-induced hematoma or hemorrhagic cyst [8,9].…”

Section: Discussionmentioning

confidence: 99%

Rare Papillary Breast Carcinoma Incidentally Discovered After Trauma-Induced Hematoma

Li¹,

Nguyen²,

Williams³

et al. 2021

Cureus

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Papillary carcinoma of the breast is rare, comprising only 0.5% incidence of all breast cancers. Clinically the disease presents in postmenopausal women as a painless breast lump with possible bloody nipple discharge. Prognosis is favorable due to its slow growth. We present a 61-year-old woman incidentally diagnosed with papillary breast carcinoma after presenting with a trauma-induced hematoma of the right breast. The patient presented to our surgery oncology clinic for persistent right breast swelling secondary to a fall, despite initial incision and drainage (I&D) six weeks prior. She had no history of breast cancer. On presentation, her right breast was distended demonstrating an approximately 20cm ill-defined solid mass with skin changes consistent with a tense hematoma. CT scan demonstrated a large complex cystic and solid breast mass measuring 15.2cmx11.8cmx15.2cm with irregular peripheral solid hyperdense polypoid components. She then underwent a right breast incisional biopsy and hematoma evacuation. Frozen sections of the mass outer cavity wall and papillary projections were consistent with encapsulated papillary carcinoma (EPC). The patient was lost to follow-up and did not obtain definitive treatment. Breast cancer rarely presents as a breast hematoma. However, as in this case, if the hematoma fails to resolve, further investigation is warranted. The prognosis of EPC is excellent when identified and treated appropriately.

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Section: Discussionmentioning

confidence: 99%

Rare Papillary Breast Carcinoma Incidentally Discovered After Trauma-Induced Hematoma

Li¹,

Nguyen²,

Williams³

et al. 2021

Cureus

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“…It also possesses anti-coagulant properties and is used in the treatment of bruises and ecchymosis, where there is extravasation of blood. 34 Several case reports suggest the development of BCa after trauma, 35 36 especially blunt injuries. 37 However, to the best of our knowledge, no systematic studies have been conducted to investigate the anti-cancer potential of Arn .…”

Section: Discussionmentioning

confidence: 99%

Computational and In Vitro Approaches to Elucidate the Anti-cancer Effects of Arnica montana in Hormone-Dependent Breast Cancer

et al. 2022

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Background Breast cancer is the most common cancer in women worldwide. Use of homeopathic medicines for the treatment of cancers has increased in the last several years. Arnica montana is an anti-inflammatory homeopathic medicine used in traumatic conditions and because of this property we performed investigations for its potential as a chemotherapeutic agent against breast cancer. Methods An ethanolic extract of Arnica montana (mother tincture, MT), prepared according to the Homoeopathic Pharmacopoeia of India, was characterized by gas chromatography–mass spectroscopy (GC–MS), followed by computational (in silico) analysis using molecular docking, to identify specific compounds that can bind and modulate the activity of key proteins involved in breast cancer survival and progression. To validate the in silico findings, in a controlled experiment breast cancer cells (MCF7) were treated in vitro with Arnica montana and the cytotoxic effects assessed by flowcytometry, fluorescence microscopy, scratch assay, clonogenic potential and gene expression analysis. Results Phytochemical characterization of ethanolic extract of Arn MT by GC–MS allowed identification of several compounds. Caryophyllene oxide and 7-hydroxycadalene were selected for molecular docking studies, based on their potential drug-like properties. These compounds displayed selective binding affinity to some of the recognized target proteins of breast cancer, which included estrogen receptor alpha (ERα), progesterone receptor (PR), epidermal growth factor receptor (EGFR), mTOR (mechanistic target of rapamycin) and E-cadherin. In vitro studies revealed induction of apoptosis in MCF7 cells following treatment with Arn MT. Furthermore, treatment with Arn MT revealed its ability to inhibit migration and colony forming abilities of the cancer cells. Conclusion Considering the apoptotic and anti-migratory effects of Arnica montana in breast cancer cells in vitro, there is a need for this medicine to be further validated in an in vivo model.

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A case of breast cancer developed in the chronic expanding hematoma cyst wall

Sudo,

Oura

2024

Radiology Case Reports

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Breast Trauma and Triple-Negative Hemorrhagic Cystic Carcinoma: Management and Treatment

Cited by 3 publications

References 18 publications

Rare Papillary Breast Carcinoma Incidentally Discovered After Trauma-Induced Hematoma

Rare Papillary Breast Carcinoma Incidentally Discovered After Trauma-Induced Hematoma

Computational and In Vitro Approaches to Elucidate the Anti-cancer Effects of Arnica montana in Hormone-Dependent Breast Cancer

A case of breast cancer developed in the chronic expanding hematoma cyst wall

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