Breast tissue density change after oophorectomy in BRCA mutation carrier patients using visual and volumetric analysis

Dunant, Ariane; Delaloge, Suzette; Wehrer, Delphine; Moussa, Tania; Caron, Olivier; Balleyguier, Corinne

doi:10.1259/bjr.20170163

Cited by 3 publications

(2 citation statements)

References 25 publications

(27 reference statements)

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“…In addition, chemoprevention trials have shown that tamoxifen treatment is associated with decreasing breast density [ 33 – 35 ]. Also, surgical removal of both ovaries (bilateral oophorectomy) is associated with decreasing breast density [ 36 , 37 ]. However, there have been very limited studies in which other factors were examined for potential association with longitudinal changes in breast density.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Longitudinal Changes in Mammographic Density in a Multiethnic Breast Screening Cohort of Postmenopausal Women

Park,

Ziogas,

Feig

et al. 2023

The Breast Journal

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Background. Breast density is an important risk factor for breast cancer and is known to be associated with characteristics such as age, race, and hormone levels; however, it is unclear what factors contribute to changes in breast density in postmenopausal women over time. Understanding factors associated with density changes may enable a better understanding of breast cancer risk and facilitate potential strategies for prevention. Methods. This study investigated potential associations between personal factors and changes in mammographic density in a cohort of 3,392 postmenopausal women with no personal history of breast cancer between 2011 and 2017. Self-reported information on demographics, breast and reproductive history, and lifestyle factors, including body mass index (BMI), alcohol intake, smoking, and physical activity, was collected by an electronic intake form, and breast imaging reporting and database system (BI-RADS) mammographic density scores were obtained from electronic medical records. Factors associated with a longitudinal increase or decrease in mammographic density were identified using Fisher’s exact test and multivariate conditional logistic regression. Results. 7.9% of women exhibited a longitudinal decrease in mammographic density, 6.7% exhibited an increase, and 85.4% exhibited no change. Longitudinal changes in mammographic density were correlated with age, race/ethnicity, and age at menopause in the univariate analysis. In the multivariate analysis, Asian women were more likely to exhibit a longitudinal increase in mammographic density and less likely to exhibit a decrease compared to White women. On the other hand, obese women were less likely to exhibit an increase and more likely to exhibit a decrease compared to normal weight women. Women who underwent menopause at age 55 years or older were less likely to exhibit a decrease in mammographic density compared to women who underwent menopause at a younger age. Besides obesity, lifestyle factors (alcohol intake, smoking, and physical activity) were not associated with longitudinal changes in mammographic density. Conclusions. The associations we observed between Asian race/obesity and longitudinal changes in BI-RADS density in postmenopausal women are paradoxical in that breast cancer risk is lower in Asian women and higher in obese women. However, the association between later age at menopause and a decreased likelihood of decreasing in BI-RADS density over time is consistent with later age at menopause being a risk factor for breast cancer and suggests a potential relationship between greater cumulative lifetime estrogen exposure and relative stability in breast density after menopause. Our findings support the complexity of the relationships between breast density, BMI, hormone exposure, and breast cancer risk.

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Section: Discussionmentioning

confidence: 99%

Factors Associated with Longitudinal Changes in Mammographic Density in a Multiethnic Breast Screening Cohort of Postmenopausal Women

Park,

Ziogas,

Feig

et al. 2023

The Breast Journal

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“…Furthermore, younger high-risk women who may benefit from CESM screening are also a target population for prevention strategies. Mammographic VBD and measurements of fibroglandular volume have been demonstrated as useful markers of breast density change associated with interventions that include chemoprevention [ 46 , 47 , 48 ], oophorectomy [ 49 ], diet [ 50 ], and weight loss [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Quantitative Breast Density in Contrast-Enhanced Mammography

Gennaro

Hill²,

Bezzon

et al. 2021

JCM

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Contrast-enhanced mammography (CEM) demonstrates a potential role in personalized screening models, in particular for women at increased risk and women with dense breasts. In this study, volumetric breast density (VBD) measured in CEM images was compared with VBD obtained from digital mammography (DM) or tomosynthesis (DBT) images. A total of 150 women who underwent CEM between March 2019 and December 2020, having at least a DM/DBT study performed before/after CEM, were included. Low-energy CEM (LE-CEM) and DM/DBT images were processed with automatic software to obtain the VBD. VBDs from the paired datasets were compared by Wilcoxon tests. A multivariate regression model was applied to analyze the relationship between VBD differences and multiple independent variables certainly or potentially affecting VBD. Median VBD was comparable for LE-CEM and DM/DBT (12.73% vs. 12.39%), not evidencing any statistically significant difference (p = 0.5855). VBD differences between LE-CEM and DM were associated with significant differences of glandular volume, breast thickness, compression force and pressure, contact area, and nipple-to-posterior-edge distance, i.e., variables reflecting differences in breast positioning (coefficient of determination 0.6023; multiple correlation coefficient 0.7761). Volumetric breast density was obtained from low-energy contrast-enhanced spectral mammography and was not significantly different from volumetric breast density measured from standard mammograms.

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Breast Density

Kim,

Lewin

2024

Radiologic Clinics of North America

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Breast tissue density change after oophorectomy in BRCA mutation carrier patients using visual and volumetric analysis

Cited by 3 publications

References 25 publications

Factors Associated with Longitudinal Changes in Mammographic Density in a Multiethnic Breast Screening Cohort of Postmenopausal Women

Factors Associated with Longitudinal Changes in Mammographic Density in a Multiethnic Breast Screening Cohort of Postmenopausal Women

Quantitative Breast Density in Contrast-Enhanced Mammography

Breast Density

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