Breast MR Imaging during or Soon after Radiation Therapy

Morakkabati, N.; Leutner, C.; Schmiedel, A; Schild, Hans H.; Kuhl, Christiane K.

doi:10.1148/radiol.2293020167

Cited by 77 publications

(36 citation statements)

References 37 publications

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“…Anhand von MRT-Untersuchungen der Brust unter Bestrahlung lässt sich in der T2-Wichtung, neben der deutlichen Verdickung der Kutis, ein verstärktes Enhancement des intramammären Gewebes durch den erhöhten Wassergehalt nachweisen. Begleitend dazu werden gelegentlich auch fokale Mehranreicherungen im Sinne von Gewebsnekrosen beobachtet [12]. Des weiteren können Entzündungsreaktionen aber auch zu einer Obstruktion von Lymphgefäßen und somit zu einer Behinderung des Lymphabflusses führen.…”

Section: Diskussionunclassified

Volumetrische Veränderungen der Mamma während der Radiotherapie

Trog¹,

Garbe²,

Lutterbey³

et al. 2005

Strahlenther Onkol

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Section: Diskussionunclassified

Volumetrische Veränderungen der Mamma während der Radiotherapie

Trog¹,

Garbe²,

Lutterbey³

et al. 2005

Strahlenther Onkol

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“…It is widely used as a supplementary modality to mammography and ultrasound, mainly for local staging of recently diagnosed breast cancers and recently as a screening tool for patients at a high risk. [1][2][3][4][5][6] Dynamic contrast-enhanced (DCE)-MRI using gadolinium contrast material offers high sensitivity in detecting breast lesions, and thus it has been widely used in the past decades to locate breast cancers, to show the extent of the disease and to demonstrate small multifocal breast tumours. The sensitivity ranges in literature between 89% and 100%.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of diffusion kurtosis imaging in characterization of breast lesions

Christou

Ghiatas²,

Priovolos

et al. 2017

BJR

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Objective: The aim of this study was to evaluate the accuracy of diffusion kurtosis in the characterization and differentiation of breast lesions. Methods: 49 females with 53 breast lesions underwent breast MRI. The MRI magnetic field is 1.5 T, and the protocol is standard MRI sequences, dynamic sequences pre-and post-contrast agent administration and diffusion images. Diffusion kurtosis imaging (DKI) was applied as part of our standard breast MRΙ protocol. Two experienced radiologists on breast MRI, blinded to the final diagnosis, reviewed the parametric maps and placed a volume of interest on all slices including each lesion. Kurtosis [K apparent (K app )] and corrected apparent diffusion coefficient [D apparent (D app )] median values were then calculated from the whole-lesion histogram analysis. Receiver-operating characteristic analysis was used to determine the most effective cut-off values for the differentiation between benign and malignant pathologies. Histological analysis of the breast lesions was performed, and further comparative analysis of the results was performed to investigate the accuracy of the method. Conclusion: DKI is an accurate additional tool for the characterization and differentiation of breast lesions with high K app and D app sensitivity and specificity rates. Advances in knowledge: DKI is able to distinguish benign from malignant breast pathologies. DKI increases the specificity of breast MRI. INTRODUCTIONBreast MRI is a well-established method for the evaluation of breast pathologies. It is widely used as a supplementary modality to mammography and ultrasound, mainly for local staging of recently diagnosed breast cancers and recently as a screening tool for patients at a high risk.

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“…It is widely used in a variety of clinical settings, such as local staging in patients recently diagnosed with breast cancer and as a screening tool for high-risk females. [8][9][10][11][12][13] DCE breast MRI is the most proposed imaging method, with a high sensitivity ranging between 89 and 100%. However, its suboptimal specificity (reportedly around 75%) imposes a significant setback, particularly in patients referred for evaluation of inconclusive findings on clinical examination and conventional breast imaging.…”

Section: Discussionmentioning

confidence: 99%

Whole-lesion apparent diffusion coefficient (ADC) metrics as a marker of breast tumour characterization—comparison between ADC value and ADC entropy

Bougias¹,

Ghiatas²,

Priovolos³

et al. 2016

The British Journal of Radiology

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Objective: To prospectively assess the role of wholelesion apparent diffusion coefficient (ADC) metrics in the characterization of breast tumours by comparing ADC value with ADC entropy. Methods: 49 patients with 53 breast lesions underwent phased-array breast coil 1.5-T MRI. Two radiologists experienced in breast MRI, blinded to the final diagnosis, reviewed the ADC maps and placed a volume of interest on all slices including each lesion on the ADC map to obtain whole-lesion mean ADC value and ADC entropy. The mean ADC value and ADC entropy in benign and malignant lesions were compared by the Mann-Whitney U-test. Receiver-operating characteristic analysis was performed to assess the sensitivity and specificity of the two variables in the characterization of the breast lesions. Results: The benign (n 5 19) and malignant lesions (n 5 34) had mean diameters of 20.8 mm (10.1-31.5 mm) and 26.4 mm (10.5-42.3 mm), respectively. The mean ADC value of the malignant lesions was significantly lower than that of the benign ones (0.87 3 10 23 vs , the sensitivity and specificity for diagnosing malignancy became optimal (97.1% and 93.7, respectively) with an area under the curve (AUC) of 0.975. With regard to ADC entropy, the sensitivity and specificity at a cut-off of 5.18 were 67.6 and 68.7%, respectively, with an AUC of 0.664. Conclusion: Whole-lesion mean ADC could be a helpful index in the characterization of suspicious breast lesions, with higher sensitivity and specificity than ADC entropy. Advances in knowledge: Two separate parameters of the whole-lesion histogram were compared for their diagnostic accuracy in characterizing breast lesions. Mean ADC was found to be able to characterize breast lesions, whereas entropy proved to be unable to differentiate benign from malignant breast lesions. It is, however, likely that entropy may distinguish these two groups if a larger cohort were used, or the fact that this may be influenced by the molecular subtypes of breast cancers included.

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Breast MR Imaging during or Soon after Radiation Therapy

Abstract: Radiation-induced changes occur at MR imaging during or up to 3 months after radiation therapy but are much less severe than reported. Detection and characterization of lesions were feasible with comparable diagnostic accuracies in irradiated and nonirradiated breasts.

Cited by 77 publications

References 37 publications

Volumetrische Veränderungen der Mamma während der Radiotherapie

Volumetrische Veränderungen der Mamma während der Radiotherapie

Accuracy of diffusion kurtosis imaging in characterization of breast lesions

Whole-lesion apparent diffusion coefficient (ADC) metrics as a marker of breast tumour characterization—comparison between ADC value and ADC entropy

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