Breast milk in neonate oral care: oropharyngeal effects in extremely preterm infants

Bourgeois-Nicolaos, Nadège; Raynor, Alexandre; Shankar-Aguilera, Shivani; Schwartz, Eden; Doucet‐Populaire, Florence; Luca, Danièle De

doi:10.1007/s00431-022-04692-5

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…Quite a few articles were excluded after the full-text screening because the analysis of the airway microbiome was performed without using culture-independent molecular techniques and without reporting at least one alpha- or beta-diversity metric or a microbial profile [ 41 ]. Similarly, several studies were excluded because they exclusively analyzed the presence and quantity of specific organisms in samples from the airways, subsequently correlating them with certain outcomes, without examining the respiratory microbiota as a whole [ 42 , 43 ].…”

Section: Studies Excluded After Full-text Screeningmentioning

confidence: 99%

Preterm Infants’ Airway Microbiome: A Scoping Review of the Current Evidence

Colombo,

Nava,

Castoldi

et al. 2024

Nutrients

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The aim of this scoping review was to investigate and synthesize existing evidence on the airway microbiome of preterm infants to outline the prognostic and therapeutic significance of these microbiomes within the preterm population and identify gaps in current knowledge, proposing avenues for future research. We performed a scoping review of the literature following the Arskey and O’Malley framework. In accordance with our inclusion criteria and the intended purpose of this scoping review, we identified a total of 21 articles. The investigation of the airway microbiome in preterm infants has revealed new insights into its unique characteristics, highlighting distinct dynamics when compared to term infants. Perinatal factors, such as the mode of delivery, chorioamnionitis, the respiratory support, and antibiotic treatment, could impact the composition of the airway microbiome. The ‘gut–lung axis’, examining the link between the lung and gut microbiome as well as modifications in respiratory microbiome across different sites and over time, has also been explored. Furthermore, correlations between the airway microbiome and adverse outcomes, such as bronchopulmonary dysplasia (BPD), have been established. Additional research in neonatal care is essential to understand the early colonization of infants’ airways and explore methods for its optimization. The critical opportunity to shape long-term health through microbiome-mediated effects likely lies within the neonatal period.

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Section: Studies Excluded After Full-text Screeningmentioning

confidence: 99%