Breast milk from mothers of children with newly developed atopic eczema has low levels of long chain polyunsaturated fatty acids

Businco, L; Ioppi, Mauro; Morse, N.; Nisini, R.; Wright, S.

doi:10.1016/0091-6749(93)90315-7

Cited by 70 publications

(52 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nonetheless, neonatal IgE is thought to be a determinant of later atopy and the present results seem to contradict the known relationship between perinatal EFAs and the later development of atopy (14,27,28). However, most studies used clinical atopic outcomes or composite outcomes including clinical and laboratory data; the study in infants that showed an association between cord blood EFAs and later atopy did not find an association with later IgE either (14).…”

Section: Discussioncontrasting

confidence: 55%

Determinants of neonatal IgE level: parity, maternal age, birth season and perinatal essential fatty acid status in infants of atopic mothers

Gool

Thijs

Dagnelie

et al. 2004

Allergy

View full text Add to dashboard Cite

Objective:The hygiene hypothesis suggests that the protective 'siblings effect' against atopic diseases such as atopic dermatitis, allergic asthma and hay fever is a result of recurrent infections during early childhood. A recent study and review have indicated that this protective effect may already arise in utero. Lower n-3 essential fatty acid (EFA) status is associated with increased parity, and EFA status has also been related to atopy. The present study confirms the negative association between parity and neonatal immunoglobulin E (IgE) levels and further unravel the role of perinatal EFA status. Methodology: In a prospective cohort study in 184 atopic mothers and their neonates, we simultaneously measured serum total IgE and EFA levels in plasma phospholipids, both in the mother at 34-36 weeks of gestation and in the neonate at the age of 1 week. Linear regression analysis was used to estimate the effect of parity on maternal and neonatal IgE and EFA status, and the independent effects of parity and EFA status on IgE, controlling for confounding factors such as maternal age and birth season. Results: Parity was associated with lower neonatal IgE level (P < 0.01), as well as with lower docosahexanoic acid (DHA, 22:6n-3) status of the mother (P = 0.01) but not of the neonate (P > 0.69). In the multivariate analysis, higher parity, higher maternal IgE, lower maternal age and birth in the first 3 months of the year were independently associated with neonatal IgE level. No association was detected between maternal or neonatal EFA status and neonatal IgE. Conclusions: As neonatal total serum IgE is predictive of later atopy, our results support the hypothesis that the sibling effect in atopy is already being programmed in utero. Our data also confirm earlier findings that DHA status is lower in multiparous women, but this did not confound the relation between parity and neonatal IgE.

show abstract

Section: Discussioncontrasting

confidence: 55%

Determinants of neonatal IgE level: parity, maternal age, birth season and perinatal essential fatty acid status in infants of atopic mothers

Gool

Thijs

Dagnelie

et al. 2004

Allergy

View full text Add to dashboard Cite

show abstract

“…On the other hand, certain individual polyunsaturated fatty acids, eg g-linolenic acid (18:3 n-6), eicosapentaenoic (20:5 n-3) and docosahexaenoic acid (22:6 n-3), have been associated with anti-in¯ammatory properties (Kankaanpa Èa È et al, 1999), a concept again supported by the clinical demonstration that dietary supplementation of g-linolenic acid reduces the severity of atopic eczema (Biagi et al, 1994). It has also been demonstrated that there are differences in fatty acid composition of breast milk associated with atopic disease, possibly indicating disturbed long chain polyunsaturated fatty acid metabolism in atopic subjects (Businco et al, 1993;Yu et al, 1998). We found differences in total fat and saturated fat intakes between atopic and non-atopic mothers, suggesting that the previous ®ndings could be partly explained by different dietary intake.…”

Section: Discussionmentioning

confidence: 47%

Maternal diet rich in saturated fat during breastfeeding is associated with atopic sensitization of the infant

2000

View full text Add to dashboard Cite

Objective: To investigate the impact of maternal diet during breastfeeding on atopic sensitization of infants at risk. Design: Prospective cohort study. Setting: Turku University Central Hospital, Finland. Subjects and methods: Altogether 114 infants with a family history of atopic disease were followed during their ®rst year of life. The mothers completed a 4 day food record during breastfeeding just before the infants were 3 months old. Atopic sensitization of the infants was determined by a positive skin prick test result at 12 months. Results: Positive skin prick test reactivity to at least one antigen was detected in 27a114 (24%) infants at 12 months. The energy intake of the mothers was low, mean 8.0 MJaday (95% CI 7.7 ± 8.3), and the proportion of energy derived from fat was high, mean 36.6 E% (95% CI 35.6 ± 37.6). Atopic mothers had a higher intake of total fat and saturated fat and a lower intake of carbohydrate as a percentage of total energy intake than nonatopic mothers; P 0.017, P 0.050, P 0.004 respectively. Maternal intake of saturated fat during breastfeeding was associated with atopic sensitization of the infant, OR 1.16 (95% CI 1.001 ± 1.36); P 0.048 irrespective of the maternal atopic status. Conclusions: Our results show that an unbalanced maternal diet during breastfeeding may be a risk factor underlying the later development of atopic sensitization of the infant regardless of maternal atopic disease. The observation thus extends ®ndings implying that early nutrition programmes the subsequent health of the child to the risk of developing atopic disease.

show abstract

“…Breast milk obtained from healthy mothers of infants with newly developed atopic dermatitis had more LA and decreased proportion of n-3 PUFA than the milk of healthy mothers of non-atopic infants (Businco et al, 1993;Yu et al, 1998). Hodge et al, (1996) and Kankaapää et al (2001) suggest that the excessive dietary supply of n-6 PUFA or reduced proportion of n-3 PUFA, may be a risk factor for the development of atopic disease, even though relationship between PUFA and atopic diseases is still controversial (Koletzko, 2000;Duchén, 2001).…”

Section: Fatty Acid Composition Of Human Milkmentioning

confidence: 86%

Fatty acid and sn-2 fatty acid composition in human milk from Granada (Spain) and in infant formulas

et al. 2002

View full text Add to dashboard Cite

Objective: To investigate differences in fatty acid and sn-2 fatty acid composition in colostrum, transitional and mature human milk, and in term infant formulas. Setting: Departament de Nutrició i Bromatologia, University of Barcelona, Spain and University Hospital of Granada, Spain. Subjects: One-hundred and twenty mothers and 11 available types of infant formulas for term infants. Design: We analysed the fatty acid composition of colostrum (n ¼ 40), transitional milk (n ¼ 40), mature milk (n ¼ 40) and 11 infant formulas. We also analysed the fatty acid composition at sn-2 position in colostrum (n ¼ 12), transitional milk (n ¼ 12), mature milk (n ¼ 12), and the 11 infant formulas. Results: Human milk in Spain had low saturated fatty acids, high monounsaturated fatty acids and high linolenic acid. Infant formulas and mature human milk had similar fatty acid composition. In mature milk, palmitic acid was preferentially esterified at the sn-2 position (86.25%), and oleic and linoleic acids were predominantly esterified at the sn-1,3 positions (12.22 and 22.27%, respectively, in the sn-2 position). In infant formulas, palmitic acid was preferentially esterified at the sn-1,3 positions and oleic and linoleic acids had higher percentages at the sn-2 position than they do in human milk. Conclusion: Fatty acid composition of human milk in Spain seems to reflect the Mediterranean dietary habits of mothers. Infant formulas resemble the fatty acid profile of human milk, but the distribution of fatty acids at the sn-2 position is markedly different.

show abstract

Breast milk from mothers of children with newly developed atopic eczema has low levels of long chain polyunsaturated fatty acids

Cited by 70 publications

References 28 publications

Determinants of neonatal IgE level: parity, maternal age, birth season and perinatal essential fatty acid status in infants of atopic mothers

Determinants of neonatal IgE level: parity, maternal age, birth season and perinatal essential fatty acid status in infants of atopic mothers

Maternal diet rich in saturated fat during breastfeeding is associated with atopic sensitization of the infant

Fatty acid and sn-2 fatty acid composition in human milk from Granada (Spain) and in infant formulas

Contact Info

Product

Resources

About